Amidrine

Amidrine, Midrin, Nodolor, Duradrin, IDA, Migquin, Migrin-A, Migrazone or Epidrine is a combination drug consisting of paracetamol, dichloralphenazone and isometheptene used to treat migraines and severe, refractory headaches.^[1]

Components[]

• Paracetamol, also known as acetaminophen, is a common over-the-counter pain reliever and fever reducer.
• Dichloralphenazone is a prodrug of two pharmacologically distinct agents: the sedative agent, chloral hydrate, as well as antipyrine, a non-steroidal anti-inflammatory drug that works to decrease inflammation.
• Isometheptene is a sympathomimetic drug that works by inducing vasoconstriction, causing constriction of cerebral blood vessels and reducing migraine symptoms.

Availability[]

Midrin was discontinued by Caraco Pharmaceuticals as of 2009, after an FDA seizure of 33 drugs manufactured by Caraco Pharmaceuticals due to cGMP (Current Good Manufacturing Practices) violations.^[2] Generic forms of Amidrine were also discontinued due to loss of FDA grandfather approval status. Thus, manufacturer interest faded. The discontinued generic forms are: Amidrine (Actavis), Duradrin (Barr), I.D.A (Teva), Migquin (Qualitest), Migrin-A (Prasco) and Migrazone (Breckenridge).^[3] However, it is now being manufactured by and marketed under the name Nodolor, as of April 2014. It can also be obtained through a compounding pharmacy with a doctor's prescription.

References[]

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