BRCT domain

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	2azmB:1906-1957 2adoB:1906-1957 2etxA:1906-1957 1kzyC:1795-1835 1l0bA:1589-1669 1t2vC:1646-1723 1n5oX:1646-1723 1t2uA:1646-1723 1jnxX:1646-1723 1t15A:1646-1723 1t29A:1646-1723 1y98A:1646-1723 2couA:91-166 1l7bA:589-664 2cokA:385-463 1wf6A:354-431 1ik9C:681-717 1cdzA:538-616 1oqaA:1756-1842 2coeA:27-111

BRCA1 C Terminus (BRCT) domain
BRCA1 C Terminus (BRCT) domain
	Structure of an XRCC1 BRCT domain.
Identifiers
Symbol	BRCT
Pfam	PF00533
InterPro	IPR001357
SCOP2	1cdz / SCOPe / SUPFAM
CDD	cd00027
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	2azmB:1906-1957 2adoB:1906-1957 2etxA:1906-1957 1kzyC:1795-1835 1l0bA:1589-1669 1t2vC:1646-1723 1n5oX:1646-1723 1t2uA:1646-1723 1jnxX:1646-1723 1t15A:1646-1723 1t29A:1646-1723 1y98A:1646-1723 2couA:91-166 1l7bA:589-664 2cokA:385-463 1wf6A:354-431 1ik9C:681-717 1cdzA:538-616 1oqaA:1756-1842 2coeA:27-111

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.

The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage,^[2] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.^[3]

Examples[]

Human proteins containing this domain include:

References[]

^ Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17 (21): 6404–11. doi:10.1093/emboj/17.21.6404. PMC 1170965. PMID 9799248.
^ Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF (1997). "A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins". FASEB J. 11 (1): 68–76. doi:10.1096/fasebj.11.1.9034168. PMID 9034168.
^ Yu X, Chini CC, He M, Mer G, Chen J (2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–642. doi:10.1126/science.1088753. PMID 14576433. S2CID 29407635.

External links[]

Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_1
Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_2
Eukaryotic Linear Motif resource motif class LIG_BRCT_MDC1_1

This article incorporates text from the public domain Pfam and InterPro: IPR001357

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[pmid9799248-1] Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17 (21): 6404–11. doi:10.1093/emboj/17.21.6404. PMC 1170965. PMID 9799248.

[PUB00001533-2] Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF (1997). "A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins". FASEB J. 11 (1): 68–76. doi:10.1096/fasebj.11.1.9034168. PMID 9034168.

[PUB00014805-3] Yu X, Chini CC, He M, Mer G, Chen J (2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–642. doi:10.1126/science.1088753. PMID 14576433. S2CID 29407635.

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