Carrie L. Partch

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Carrie L. Partch
Born
Carrie L. Stentz

(1973-11-30) 30 November 1973 (age 48)
Kirkland, Washington, USA
Alma mater
Scientific career
FieldsChronobiology, Biochemistry, Biophysics, Structural Biology
InstitutionsUniversity of California, Santa Cruz
ThesisSignal transduction mechanisms of cryptochrome (2006)
Doctoral advisorAziz Sancar
Websitehttps://www.partchlab.com/

Carrie L. Partch (born 30 November 1973) is an American protein biochemist and circadian biologist. Partch is currently a Professor in the Department of Chemistry and Biochemistry at the University of California, Santa Cruz.[1][2] She is noted for her work using biochemical and biophysical techniques to study the mechanisms of circadian rhythmicity across multiple organisms.

Academic career[]

Partch studied undergraduate Biochemistry with a minor in Italian at the University of Washington.[3] After three years as a research technician at Oregon Health Sciences University,[3] she went on to join the lab of Nobel Laureate Aziz Sancar at the University of North Carolina at Chapel Hill where she undertook her PhD research on the subject of signal transduction mechanisms by cryptochrome proteins.[4][5]

For her post-doctoral research, Partch focussed on the interaction of the aryl hydrocarbon receptor nuclear translocator with its heterodimeric binding partner, the transcription factor HIF-2α, under Kevin Gardner at University of Texas Southwestern Medical Center.[6][7] She subsequently moved this expertise into the circadian field to work with Joseph Takahashi, also at University of Texas Southwestern Medical Center, where she studied the related Basic Helix-Loop-Helix-PAS transcription factor that drives circadian rhythmicity, CLOCK:BMAL1.[8]

Current research[]

The Partch lab’s research focusses on the proteins known to circadian timekeeping, and utilizes a range of structural and biophysical techniques in order to characterize the biological role of these proteins including NMR spectroscopy and X-ray crystallography.[3] Current projects include both mammalian and cyanobacterial timekeeping mechanisms. Notably, the lab recently published work in the journal Science, elucidating the role of the protein SasA in the cooperative binding of KaiB to the KaiC hexamer in the cyanobacterial circadian clock.[9] In 2020, the lab published a paper describing how the mammalian circadian protein PERIOD and its cognate kinase Casein Kinase 1 form a molecular switch to regulate PERIOD protein stability, and so circadian periodicity[10]

Awards[]

References[]

  1. ^ "UCSC Campus Directory". Archived from the original on 11 May 2021.
  2. ^ "Carrie Partch". scholar.google.com. Retrieved 11 December 2021.
  3. ^ a b c "Partch Lab Website". Archived from the original on 12 July 2016.
  4. ^ Partch, Carrie L.; Clarkson, Michael W.; Özgür, Sezgin; Lee, Andrew L.; Sancar, Aziz (1 March 2005). "Role of Structural Plasticity in Signal Transduction by the Cryptochrome Blue-Light Photoreceptor". Biochemistry. 44 (10): 3795–3805. doi:10.1021/bi047545g. ISSN 0006-2960. PMID 15751956.
  5. ^ Partch, C. L.; Shields, K. F.; Thompson, C. L.; Selby, C. P.; Sancar, A. (5 July 2006). "Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5". Proceedings of the National Academy of Sciences. 103 (27): 10467–10472. Bibcode:2006PNAS..10310467P. doi:10.1073/pnas.0604138103. ISSN 0027-8424. PMC 1502481. PMID 16790549.
  6. ^ Partch, Carrie L.; Card, Paul B.; Amezcua, Carlos A.; Gardner, Kevin H. (May 2009). "Molecular Basis of Coiled Coil Coactivator Recruitment by the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT)". Journal of Biological Chemistry. 284 (22): 15184–15192. doi:10.1074/jbc.M808479200. PMC 2685699. PMID 19324882.
  7. ^ Partch, Carrie L.; Gardner, Kevin H. (10 May 2011). "Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B". Proceedings of the National Academy of Sciences. 108 (19): 7739–7744. Bibcode:2011PNAS..108.7739P. doi:10.1073/pnas.1101357108. ISSN 0027-8424. PMC 3093465. PMID 21512126.
  8. ^ Huang, Nian; Chelliah, Yogarany; Shan, Yongli; Taylor, Clinton A.; Yoo, Seung-Hee; Partch, Carrie; Green, Carla B.; Zhang, Hong; Takahashi, Joseph S. (13 July 2012). "Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex". Science. 337 (6091): 189–194. Bibcode:2012Sci...337..189H. doi:10.1126/science.1222804. ISSN 0036-8075. PMC 3694778. PMID 22653727.
  9. ^ Chavan, Archana G.; Swan, Jeffrey A.; Heisler, Joel; Sancar, Cigdem; Ernst, Dustin C.; Fang, Mingxu; Palacios, Joseph G.; Spangler, Rebecca K.; Bagshaw, Clive R.; Tripathi, Sarvind; Crosby, Priya (8 October 2021). "Reconstitution of an intact clock reveals mechanisms of circadian timekeeping". Science. 374 (6564): eabd4453. doi:10.1126/science.abd4453. ISSN 0036-8075. PMC 8686788. PMID 34618577. S2CID 238475334.
  10. ^ Philpott, Jonathan M; Narasimamurthy, Rajesh; Ricci, Clarisse G; Freeberg, Alfred M; Hunt, Sabrina R; Yee, Lauren E; Pelofsky, Rebecca S; Tripathi, Sarvind; Virshup, David M; Partch, Carrie L (11 February 2020). "Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch". eLife. 9: e52343. doi:10.7554/eLife.52343. ISSN 2050-084X. PMC 7012598. PMID 32043967.
  11. ^ https://www.clocktool.org/clock-modules/chronohistory/item/prize-winners-of-aschoff%E2%80%99s-rule.html[dead link]
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