DUSP12

DUSP12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JNB, 4KI9
Identifiers
Aliases	DUSP12, DUSP1, YVH1, dual specificity phosphatase 12
External IDs	OMIM: 604835 MGI: 1890614 HomoloGene: 5238 GeneCards: DUSP12
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,757,238 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	170,885,540 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; brain; ; bone marrow; ; embryo; ; prostate; ; cerebral cortex; ; Body of pancreas;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; GO:0001948 protein binding; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; metal ion binding; zinc ion binding; phosphatase activity; nucleic acid binding; kinase binding;
Cellular component	cytosol; nucleus; cytoplasm;
Biological process	protein dephosphorylation; cellular protein modification process; positive regulation of glucokinase activity; peptidyl-tyrosine dephosphorylation; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	11266
	80915
	ENSG00000081721
	ENSMUSG00000026659
	Q9UNI6
	Q9D0T2
	NM_007240
	NM_023173
	NP_009171
	NP_075662; NP_001343414; NP_001343415
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.^[5]^[6]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000081721 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026659 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Muda M, Manning ER, Orth K, Dixon JE (Sep 1999). "Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function". J Biol Chem. 274 (34): 23991–5. doi:10.1074/jbc.274.34.23991. PMID 10446167.
^ ^a ^b "Entrez Gene: DUSP12 dual specificity phosphatase 12".

External links[]

Overview of all the structural information available in the PDB for UniProt: Q9UNI6 (Dual specificity protein phosphatase 12) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000081721 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026659 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10446167-5] Muda M, Manning ER, Orth K, Dixon JE (Sep 1999). "Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function". J Biol Chem. 274 (34): 23991–5. doi:10.1074/jbc.274.34.23991. PMID 10446167.

[entrez-6] "Entrez Gene: DUSP12 dual specificity phosphatase 12".

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DUSP12

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