Desmosterol

Desmosterol
Names
	Preferred IUPAC name (1R,3aS,3bS,7S,9aR,9bS,11aR)-9a,11a-Dimethyl-1-[(2R)-6-methylhept-5-en-2-yl]-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-ol
	Other names Cholesta-5,24-dien-3β-ol
Identifiers
CAS Number	313-04-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:17737 ;
ChEMBL	ChEMBL455876 ;
ChemSpider	388662 ;
ECHA InfoCard	100.005.671
IUPHAR/BPS	2748;
PubChem CID	439577;
UNII	ANP93865R8 ;
CompTox Dashboard (EPA)	DTXSID10878676 ;
	show InChI
	show SMILES
Properties
Chemical formula	C27H44O
Molar mass	384.64 g/mol
Appearance	White powder
Melting point	121.5 °C (250.7 °F; 394.6 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	(what is ?)
	Infobox references

Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis.^[1] 24-dehydrocholesterol reductase catalyses the reduction of desmosterol to cholesterol.^[2] It is accumulated in desmosterolosis.

In 2014, it was named the Molecule of the Year 2012 by the International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches (ISMCBBPR).^[3]

References[]

^ Vainio, S.; Jansen, M.; Koivusalo, M.; Rog, T.; Karttunen, M.; Vattulainen, I.; Ikonen, E. (25 October 2005). "Significance of Sterol Structural Specificity: DESMOSTEROL CANNOT REPLACE CHOLESTEROL IN LIPID RAFTS". Journal of Biological Chemistry. 281 (1): 348–355. doi:10.1074/jbc.M509530200. PMID 16249181. Retrieved 30 June 2015.
^ Keber, R.; Rozman, D.; Horvat, S. (23 October 2012). "Sterols in spermatogenesis and sperm maturation". The Journal of Lipid Research. 54 (1): 20–33. doi:10.1194/jlr.R032326. PMC 3520525. PMID 23093550. Retrieved 30 June 2015.
^ Announcing ISMCBBPR's Molecule of the Year 2012

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[1] Vainio, S.; Jansen, M.; Koivusalo, M.; Rog, T.; Karttunen, M.; Vattulainen, I.; Ikonen, E. (25 October 2005). "Significance of Sterol Structural Specificity: DESMOSTEROL CANNOT REPLACE CHOLESTEROL IN LIPID RAFTS". Journal of Biological Chemistry. 281 (1): 348–355. doi:10.1074/jbc.M509530200. PMID 16249181. Retrieved 30 June 2015.

[2] Keber, R.; Rozman, D.; Horvat, S. (23 October 2012). "Sterols in spermatogenesis and sperm maturation". The Journal of Lipid Research. 54 (1): 20–33. doi:10.1194/jlr.R032326. PMC 3520525. PMID 23093550. Retrieved 30 June 2015.

[3] Announcing ISMCBBPR's Molecule of the Year 2012

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[2]

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Desmosterol

See also[]

References[]