Dyclonine

Dyclonine
Clinical data
Trade names	Sucrets
AHFS/Drugs.com	Monograph
Routes of; administration	Lozenge
ATC code	N01BX02 (WHO) R02AD04 (WHO);
Legal status
Legal status	US: OTC ;
Identifiers
	IUPAC name 1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one;
CAS Number	586-60-7 ;
PubChem CID	3180;
IUPHAR/BPS	7173;
DrugBank	DB00645 ;
ChemSpider	3068 ;
UNII	078A24Q30O;
KEGG	D07881 ;
ChEBI	CHEBI:4724 ;
ChEMBL	ChEMBL1201217 ;
CompTox Dashboard (EPA)	DTXSID6047864 ;
Chemical and physical data
Formula	C18H27NO2
Molar mass	289.419 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2;
	InChI InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 ; Key:BZEWSEKUUPWQDQ-UHFFFAOYSA-N ;
	(what is this?)

Dyclonine (Dyclocaine) is an oral anaesthetic that is the active ingredient of Sucrets, an over-the-counter throat lozenge.^[1] It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.^[2]

History[]

The product Sucrets was introduced in Baltimore, Maryland, by in 1932.^[3]

In 1966 the Federal Trade Commission ordered Merck and Company to discontinue the false claims of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges.^[4] In 1977, it was acquired by Beecham, later merging with SmithKline Beckman in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a plastic container.^[3] SmithKline Beecham, after announcing a merger with GlaxoWellcome to form GlaxoSmithKline, sold the brand in 2000 to . In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia.

References[]

^ Janice Jorgensen (1994). "Sucrets". Encyclopedia of Consumer Brands: Personal products. St. James Press. ISBN 9781558623378. Retrieved 2011-09-24.
^ Gargiulo AV, Burns GM, Huck CP (1992). "Dyclonine hydrochloride--a topical agent for managing pain". Illinois Dental Journal. 61 (4): 303–4. PMID 1286862.
^ ^a ^b "The Sucrets tin joins the age of plastics". USA Today. July 19, 1994. Retrieved 2011-09-24. Invented in Baltimore by Sharp & Dohme pharmaceutical in 1932, Sucrets have always been sold in the trademark metal box except for one 4+1⁄2-month period during the late 1960s when a tin shortage led to cardboard packaging, says [Frank Dzvonik].
^ "F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs". The New York Times. Associated Press. April 19, 1966. Retrieved 2011-09-24.

External links[]

Sucrets: Our heritage

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[1] Janice Jorgensen (1994). "Sucrets". Encyclopedia of Consumer Brands: Personal products. St. James Press. ISBN 9781558623378. Retrieved 2011-09-24.

[2] Gargiulo AV, Burns GM, Huck CP (1992). "Dyclonine hydrochloride--a topical agent for managing pain". Illinois Dental Journal. 61 (4): 303–4. PMID 1286862.

[tin-3] "The Sucrets tin joins the age of plastics". USA Today. July 19, 1994. Retrieved 2011-09-24. Invented in Baltimore by Sharp & Dohme pharmaceutical in 1932, Sucrets have always been sold in the trademark metal box except for one 4+1⁄2-month period during the late 1960s when a tin shortage led to cardboard packaging, says [Frank Dzvonik].

[4] "F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs". The New York Times. Associated Press. April 19, 1966. Retrieved 2011-09-24.

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v t Throat preparations (R02)
Antiseptics	Acriflavinium chloride Ambazone Amylmetacresol Benzalkonium Benzethonium Cetrimonium (bromide/chloride) Cetylpyridinium Chlorhexidine Chlorquinaldol Dequalinium Dichlorobenzyl alcohol Hexamidine Hexetidine Hexylresorcinol Myristyl-benzalkonium Oxyquinoline Phenol Povidone-iodine
Antibiotics	Bacitracin Fusafungine Gramicidin Neomycin Tyrothricin
Local anesthetics	Benzocaine Cocaine Dyclonine Lidocaine
Other	Flurbiprofen