FAD dependent oxidoreductase family
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| FAD dependent oxidoreductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of d-amino acid oxidase in complex with two anthranylate molecules | |||||||||
| Identifiers | |||||||||
| Symbol | DAO | ||||||||
| Pfam | PF01266 | ||||||||
| Pfam clan | CL0063 | ||||||||
| InterPro | IPR006076 | ||||||||
| PROSITE | PDOC00753 | ||||||||
| SCOP2 | 1kif / SCOPe / SUPFAM | ||||||||
| Membranome | 249 | ||||||||
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In molecular biology, the FAD dependent oxidoreductase family of proteins is a family of FAD dependent oxidoreductases. Members of this family include Glycerol-3-phosphate dehydrogenase EC 1.1.99.5, Sarcosine oxidase beta subunit EC 1.5.3.1, D-amino-acid dehydrogenase EC 1.4.99.1, D-aspartate oxidase EC 1.4.3.1.
D-amino acid oxidase EC 1.4.3.3 (DAMOX or DAO) is an FAD flavoenzyme that catalyses the oxidation of neutral and basic D-amino acids into their corresponding keto acids. DAOs have been characterised and sequenced in fungi and vertebrates where they are known to be located in the peroxisomes.
D-aspartate oxidase EC 1.4.3.1 (DASOX) [1] is an enzyme, structurally related to DAO, which catalyses the same reaction but is active only toward dicarboxylic D-amino acids. In DAO, a conserved histidine has been shown [2] to be important for the enzyme's catalytic activity.
See also[]
- DAO
- D-amino-acid dehydrogenase
- D-amino acid oxidase
- D-aspartate oxidase
- Glycerol-3-phosphate dehydrogenase
- Sarcosine oxidase
References[]
- ^ Negri A, Ceciliani F, Tedeschi G, Simonic T, Ronchi S (June 1992). "The primary structure of the flavoprotein D-aspartate oxidase from beef kidney". J. Biol. Chem. 267 (17): 11865–71. PMID 1601857.
- ^ Miyano M, Fukui K, Watanabe F, Takahashi S, Tada M, Kanashiro M, Miyake Y (January 1991). "Studies on Phe-228 and Leu-307 recombinant mutants of porcine kidney D-amino acid oxidase: expression, purification, and characterization". J. Biochem. 109 (1): 171–7. doi:10.1093/oxfordjournals.jbchem.a123340. PMID 1673125.
- Protein domains
- Molecular biology