GGL domain

Phosducin - transducin beta-gamma complex. Gamma subunit (GGL domain) colored red.
Identifiers
Symbol	G-gamma
Pfam	PF00631
InterPro	IPR001770
SMART	GGL
PROSITE	PDOC01002
SCOP2	1gp2 / SCOPe / SUPFAM
OPM protein	2bcj
CDD	cd00068
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 2bcjG:9-63 1xhmB:9-63 1omwG:9-63 1gp2G:9-60 1gg2G:9-60 2trcG:12-66 1tbgF:12-66 1b9yB:12-66 1b9xB:12-66 1gotG:12-65 1mf6A:59-66

GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.^[1]

Human proteins containing this domain[]

• GNG4; ; GNG11
• GNGT1
• RGS6; RGS7; RGS9; RGS11

See also[]

• Beta-gamma complex

References[]

Further reading[]

• Chatterjee TK, Liu Z, Fisher RA (August 2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". J. Biol. Chem. 278 (32): 30261–71. doi:10.1074/jbc.M212687200. PMID 12761221.
• Chen CK, Eversole-Cire P, Zhang H, et al. (May 2003). "Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6604–9. Bibcode:2003PNAS..100.6604C. doi:10.1073/pnas.0631825100. PMC 164494. PMID 12738888.
• Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.

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