GM2 (ganglioside)
![]() | |
Names | |
---|---|
IUPAC name
(2S,3R,4E)-3-Hydroxy-2-octadecanamidooctadec-4-en-1-yl (5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid)-(2→3)-[2-acetamido-2-deoxy-β-D-galactopyranosyl-(1→4)]-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside
| |
Preferred IUPAC name
(2S,4S,5R,6R)-5-Acetamido-2-{[(2R,3S,4R,5R,6S)-3-{[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-{[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-{[(2S,3R,4E)-3-hydroxy-2-octadecanamidooctadec-4-en-1-yl]oxy}oxan-3-yl]oxy}-5-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate | |
Other names
Ganglioside GM2; Tay–Sachs ganglioside;
β-D-GalNAc-(1→4)-[α-Neu5Ac-(2→3)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-N-octadecanoylsphingosine | |
Identifiers | |
| |
3D model (JSmol)
|
|
ChEBI | |
ChemSpider | |
PubChem CID
|
|
| |
| |
Properties | |
C67H121N3O26 | |
Molar mass | 1384.700 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
![]() ![]() ![]() | |
Infobox references | |
GM2 is a type of ganglioside. G refers to ganglioside, the M is for monosialic (as in it has one sialic acid), and 2 refers to the fact that it was the second monosialic ganglioside discovered. It is associated with GM2 gangliosidoses such as Tay–Sachs disease.[1]
See also[]
- Ganglioside GM2 activator protein
Additional images[]
Sphingolipidoses
Structures of GM1, GM2, GM3 gangliosides
References[]
- ^ Guetta E, Peleg L (2008). "Rapid Detection of Fetal Mendalian Disorders: Tay–Sachs Disease". Methods Mol. Biol. 444: 147–59. doi:10.1007/978-1-59745-066-9_11. PMID 18425478.
External links[]
- Ganglioside+GM2 at the US National Library of Medicine Medical Subject Headings (MeSH)
Categories:
- Glycolipids