Globoside

A globoside is a type of glycosphingolipid with more than one sugar as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. A glycosphingolipid that has only one sugar as the side chain is called a cerebroside.

The side chain can be cleaved by galactosidases and glucosidases. The deficiency of α-galactosidase A causes Fabry's disease, an inherited metabolic disease characterized by the accumulation of the globoside globotriaosylceramide.^[1]

Globoside (GB4) has been known as the receptor for Parvovirus B19, due to observations that B19V binds to the thin-layered chromatogram of the structure. However, the binding on its surface does not match well with the virus, which raised debates on whether or not GB4 is the cause for productive infection.^[2] Additional research using the technique Knockout Cell Line has shown that although GB4 does not have the direct entry receptor for B19V, it plays a post-entry role in productive infection.^[3]

References[]

^ Germain, D. P. (2002). "Fabry's disease (alpha-galactosidase-A deficiency): Physiopathology, clinical signs, and genetic aspects". Journal de la Société de Biologie. 196 (2): 161–73. doi:10.1051/jbio/2002196020161. PMID 12360745.
^ Nasir, Waqas; Nilsson, Jonas; Olofsson, Sigvard; Bally, Marta; Rydell, Gustaf E. (May 2014). "Parvovirus B19 VLP recognizes globoside in supported lipid bilayers". Virology. 456–457: 364–369. doi:10.1016/j.virol.2014.04.004. ISSN 1096-0341. PMID 24889255.
^ Bieri, Jan; Ros, Carlos (15 October 2019). "Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Post-entry Step for Productive Infection". Journal of Virology. 93 (20). doi:10.1128/JVI.00972-19. ISSN 0022-538X. PMC 6798098. PMID 31341051.

External links[]

Media related to Globósido at Wikimedia Commons
Globosides at the US National Library of Medicine Medical Subject Headings (MeSH)

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[1] Germain, D. P. (2002). "Fabry's disease (alpha-galactosidase-A deficiency): Physiopathology, clinical signs, and genetic aspects". Journal de la Société de Biologie. 196 (2): 161–73. doi:10.1051/jbio/2002196020161. PMID 12360745.

[2] Nasir, Waqas; Nilsson, Jonas; Olofsson, Sigvard; Bally, Marta; Rydell, Gustaf E. (May 2014). "Parvovirus B19 VLP recognizes globoside in supported lipid bilayers". Virology. 456–457: 364–369. doi:10.1016/j.virol.2014.04.004. ISSN 1096-0341. PMID 24889255.

[3] Bieri, Jan; Ros, Carlos (15 October 2019). "Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Post-entry Step for Productive Infection". Journal of Virology. 93 (20). doi:10.1128/JVI.00972-19. ISSN 0022-538X. PMC 6798098. PMID 31341051.

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