Transfusion hemosiderosis

Transfusional hemosiderosis is the accumulation of iron in the liver and heart but also endocrine organs, in patients who receive or did receive frequent blood transfusions (such as those with thalassemia, sickle cell disease, leukemia, aplastic anemia or myelodysplastic syndrome).^[why?]

Signs and symptoms[]

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Diagnosis[]

Blood transferrin test. Gold criteria is liver biopsy.^{[citation needed]}

Treatment[]

Treatment is by phlebotomy, erythrocytapheresis or chelation therapy with iron chelating agents such as deferoxamine, deferiprone or deferasirox.^[1] If iron overload has caused end-organ^{[clarification needed]} damage, this is generally irreversible and may require transplantation.

Society[]

Ted DeVita died of transfusional iron overload from too many blood transfusions.^{[citation needed]}

See also[]

• Hemosiderosis

References[]

• Lu JP, Hayashi K (1994). "Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases". Pathol. Int. 44 (3): 194–9. doi:10.1111/j.1440-1827.1994.tb02592.x. PMID 8025661. S2CID 25357672.

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