Genetic ablation

Genetic ablation is a method of modifying DNA in order to disrupt the production of a specific gene. As genetic ablation may lead to cell ablation, it can be used as a synonymous term at appropriate times.^[1] For example, Ferro, et al found that genetic ablation of GPR55, a gene encoding for a G-protein coupled receptor, reduced proliferation of tumor growth in a mouse model.^[2]

References[]

^ Breitman, ML; et al. (11 December 1987). "Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice". Science. 238 (4833): 1563–1565. Bibcode:1987Sci...238.1563B. doi:10.1126/science.3685993. PMID 3685993.
^ Ferro, R; et al. (11 December 1987). "GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine" (PDF). Oncogene. 37 (49): 6368–6382. doi:10.1038/s41388-018-0390-1. PMID 30061636. S2CID 51867238.

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[1] Breitman, ML; et al. (11 December 1987). "Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice". Science. 238 (4833): 1563–1565. Bibcode:1987Sci...238.1563B. doi:10.1126/science.3685993. PMID 3685993.

[2] Ferro, R; et al. (11 December 1987). "GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine" (PDF). Oncogene. 37 (49): 6368–6382. doi:10.1038/s41388-018-0390-1. PMID 30061636. S2CID 51867238.

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