Heparan sulfate 2-O-sulfotransferase

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Heparan sulfate 2-O-sulfotransferase
Heparan sulfate 2-O-sulfotransferase
Identifiers
Symbol	HS2ST
Pfam	PF03567
InterPro	IPR005331
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Heparan sulfate 2-O-sulfotransferase is a sulfotransferase enzyme. Heparan sulfate (HS) is a long unbranched polysaccharide found covalently attached to various proteins at the cell surface and in the extracellular matrix, where it acts as a co-receptor for a number of growth factors, , and adhesion proteins. HS-O-sulfotransferase (Hs2st) occupies a critical position in the succession of enzymes responsible for the biosynthesis of HS, catalysing the transfer of sulfate to the C2-position of selected hexuronic acid residues within the nascent HS chain. Mice that lack HS2ST undergo developmental failure after , the most dramatic effect being the complete failure of kidney development.^[1] This family is related to InterPro: IPR005331.

References[]

^ Li J, Shworak NW, Simons M (2002). "Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites". J. Cell Sci. 115 (Pt 9): 1951–1959. PMID 11956326.

This article incorporates text from the public domain Pfam and InterPro: IPR007734

[PUB00010170-1] Li J, Shworak NW, Simons M (2002). "Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites". J. Cell Sci. 115 (Pt 9): 1951–1959. PMID 11956326.

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