Sulfotransferase
| Sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystal Structure of Human Sulfotransferase SULT1A3 in Complex with Dopamine and 3-Phosphoadenosine 5-Phosphate | |||||||||
| Identifiers | |||||||||
| EC no. | 2.8.2.- | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group from a donor molecule to an acceptor alcohol or amine.[1] The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R-OSO3−), whereas an amine leads to a sulfamate (R-NH-SO3−). Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.[2]
General structure of a sulfonic acid with the blue marked functional group
Examples[]
The following are examples of sulfotransferases:
- carbohydrate sulfotransferase: CHST1, CHST2, , CHST4, CHST5, CHST6, CHST7, , , CHST10, CHST11, CHST12, , CHST14
- galactose-3-O-sulfotransferase: GAL3ST1, GAL3ST2, GAL3ST3, GAL3ST4
- heparan sulfate 2-O-sulfotransferase: HS2ST1
- heparan sulfate 3-O-sulfotransferase: HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, , ,
- heparan sulfate 6-O-sulfotransferase: , HS6ST2,
- : NDST1, NDST2, NDST3,
- tyrosylprotein sulfotransferase: TPST1, TPST2
- Estrone sulfotransferase
- Chondroitin 4-sulfotransferase
- other: SULT1A1, SULT1A2, SULT1A3, , SULT1B1, SULT1C2, SULT1C3, SULT1C4, , SULT1E1, SULT2A1, SULT2B1, SULT4A1,
See also[]
- List of EC numbers (EC 2)#EC 2.8.2: Sulfotransferases
References[]
- ^ Negishi M, Pedersen LG, Petrotchenko E, et al. (2001). "Structure and function of sulfotransferases". Arch. Biochem. Biophys. 390 (2): 149–57. doi:10.1006/abbi.2001.2368. PMID 11396917.
- ^ Rath VL, Verdugo D, Hemmerich S (2004). "Sulfotransferase structural biology and inhibitor discovery". Drug Discov. Today. 9 (23): 1003–11. doi:10.1016/S1359-6446(04)03273-8. PMID 15574316.
External links[]
- Sulfotransferases at the US National Library of Medicine Medical Subject Headings (MeSH)
 | This biochemistry article is a stub. You can help Wikipedia by . |
Categories:
- EC 2.8.2
- Biochemistry stubs