List of EC numbers (EC 1)

From Wikipedia, the free encyclopedia

This list contains a list of EC numbers for the first group, EC 1, oxidoreductases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.[1] The database is developed and maintained by Andrew McDonald.[2]

EC 1.1 Acting on the CH-OH group of donors[]

EC 1.1.1 With Nicotinamide adenine dinucleotide or NADP as acceptor[]

At present (October 2021) most of the entries from 343 onwards have no Wikipedia articles
  • EC 1.1.1.343: phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
  • EC 1.1.1.344: dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
  • EC 1.1.1.345: D-2-hydroxyacid dehydrogenase (NAD+)
  • EC 1.1.1.346: 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)
  • EC 1.1.1.347: geraniol dehydrogenase (NAD+)
  • EC 1.1.1.348: (3R)-2′-hydroxyisoflavanone reductase
  • EC 1.1.1.349: norsolorinic acid ketoreductase
  • EC 1.1.1.350: ureidoglycolate dehydrogenase (NAD+)
  • EC 1.1.1.351: phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
  • EC 1.1.1.352: 5′-hydroxyaverantin dehydrogenase
  • EC 1.1.1.353: versiconal hemiacetal acetate reductase
  • EC 1.1.1.354: farnesol dehydrogenase (NAD+)
  • EC 1.1.1.355: 2′-dehydrokanamycin reductase
  • EC 1.1.1.356: GDP-L-colitose synthase
  • EC 1.1.1.357: 3α-hydroxysteroid 3-dehydrogenase
  • EC 1.1.1.358: 2-dehydropantolactone reductase
  • EC 1.1.1.359: aldose 1-dehydrogenase [NAD(P)+]
  • EC 1.1.1.360: glucose/galactose 1-dehydrogenase
  • EC 1.1.1.361: glucose-6-phosphate 3-dehydrogenase
  • EC 1.1.1.362: aklaviketone reductase
  • EC 1.1.1.363: glucose-6-phosphate dehydrogenase [NAD(P)+]
  • EC 1.1.1.364: dTDP-4-dehydro-6-deoxy-α-D-gulose 4-ketoreductase
  • EC 1.1.1.365: D-galacturonate reductase
  • EC 1.1.1.366: L-idonate 5-dehydrogenase (NAD+)
  • EC 1.1.1.367: UDP-2-acetamido-2,6-β-L-arabino-hexul-4-ose reductase
  • EC 1.1.1.368: 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
  • EC 1.1.1.369: D-chiro-inositol 1-dehydrogenase
  • EC 1.1.1.370: scyllo-inositol 2-dehydrogenase (NAD+)
  • EC 1.1.1.371: scyllo-inositol 2-dehydrogenase (NADP+)
  • EC 1.1.1.372: D/L-glyceraldehyde reductase
  • EC 1.1.1.373: sulfolactaldehyde 3-reductase
  • EC 1.1.1.374: UDP-N-acetylglucosamine 3-dehydrogenase
  • EC 1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
  • EC 1.1.1.376: L-arabinose 1-dehydrogenase [NAD(P)+]
  • EC 1.1.1.377: L-rhamnose 1-dehydrogenase (NADP+)
  • EC 1.1.1.378: L-rhamnose 1-dehydrogenase [NAD(P)+]
  • EC 1.1.1.379: (R)-mandelate dehydrogenase
  • EC 1.1.1.380: L-gulonate 5-dehydrogenase
  • EC 1.1.1.381: 3-hydroxy acid dehydrogenase
  • EC 1.1.1.382: ketol-acid reductoisomerase (NAD+)
  • EC 1.1.1.383: ketol-acid reductoisomerase [NAD(P)+]
  • EC 1.1.1.384: dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose 3-reductase
  • EC 1.1.1.385: dihydroanticapsin dehydrogenase
  • EC 1.1.1.386: ipsdienol dehydrogenase
  • EC 1.1.1.387: L-serine 3-dehydrogenase (NAD+)
  • EC 1.1.1.388: glucose-6-phosphate dehydrogenase (NAD+)
  • EC 1.1.1.389: 2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase
  • EC 1.1.1.390: sulfoquinovose 1-dehydrogenase
  • EC 1.1.1.391: 3β-hydroxycholanate 3-dehydrogenase (NAD+)
  • EC 1.1.1.392: 3α-hydroxycholanate dehydrogenase (NADP+)
  • EC 1.1.1.393: 3β-hydroxycholanate 3-dehydrogenase (NADP+)
  • EC 1.1.1.394: aurachin B dehydrogenase
  • EC 1.1.1.395: 3α-hydroxy bile acid-CoA-ester 3-dehydrogenase
  • EC 1.1.1.396: bacteriochlorophyllide a dehydrogenase
  • EC 1.1.1.397: β-methylindole-3-pyruvate reductase
  • EC 1.1.1.398: 2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase
  • EC 1.1.1.399: 2-oxoglutarate reductase
  • EC 1.1.1.400: 2-methyl-1,2-propanediol dehydrogenase
  • EC 1.1.1.401: 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+)
  • EC 1.1.1.402: D-erythritol 1-phosphate dehydrogenase
  • EC 1.1.1.403: D-threitol dehydrogenase (NAD+)
  • EC 1.1.1.404: tetrachlorobenzoquinone reductase
  • EC 1.1.1.405: ribitol-5-phosphate 2-dehydrogenase (NADP+)
  • EC 1.1.1.406: galactitol 2-dehydrogenase (L-tagatose-forming)
  • EC 1.1.1.407: D-altritol 5-dehydrogenase
  • EC 1.1.1.408: 4-phospho-D-threonate 3-dehydrogenase
  • EC 1.1.1.409: 4-phospho-D-erythronate 3-dehydrogenase
  • EC 1.1.1.410: D-erythronate 2-dehydrogenase
  • EC 1.1.1.411: L-threonate 2-dehydrogenase
  • EC 1.1.1.412: 2-alkyl-3-oxoalkanoate reductase
  • EC 1.1.1.413: A-factor type γ-butyrolactone 1′-reductase (1S-forming)
  • EC 1.1.1.414: L-galactonate 5-dehydrogenase
  • EC 1.1.1.415: noscapine synthase
  • EC 1.1.1.416: isopyridoxal dehydrogenase (5-pyridoxolactone-forming)
  • EC 1.1.1.417: 3β-hydroxysteroid-4β-carboxylate 3-dehydrogenase (decarboxylating)
  • EC 1.1.1.418: plant 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating)
  • EC 1.1.1.419: nepetalactol dehydrogenase
  • EC 1.1.1.420: D-apiose dehydrogenase
  • EC 1.1.1.421: D-apionate oxidoisomerase
  • EC 1.1.1.422: pseudoephedrine dehydrogenase
  • EC 1.1.1.423: (1R,2S)-ephedrine 1-dehydrogenase
  • EC 1.1.1.424: D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
  • EC 1.1.1.425: levoglucosan dehydrogenase
  • EC 1.1.1.426: UDP-N-acetyl-α-D-quinovosamine dehydrogenase

EC 1.1.2 With a cytochrome as acceptor[]

  • EC 1.1.2.1: glycerolphosphate dehydrogenase. As the acceptor is now known, the enzyme has been transferred to EC 1.1.5.3, glycerol-3-phosphate dehydrogenase.
  • EC 1.1.2.2: mannitol dehydrogenase (cytochrome)
  • EC 1.1.2.3: L-lactate dehydrogenase (cytochrome)
  • EC 1.1.2.4: D-lactate dehydrogenase (cytochrome)
  • EC 1.1.2.5: D-lactate dehydrogenase (cytochrome c-553)
  • EC 1.1.2.6: polyvinyl alcohol dehydrogenase (cytochrome)
  • EC 1.1.2.7: methanol dehydrogenase (cytochrome c)
  • EC 1.1.2.8: alcohol dehydrogenase (cytochrome c)
  • EC 1.1.2.9: 1-butanol dehydrogenase (cytochrome c) *
  • EC 1.1.2.10: lanthanide-dependent methanol dehydrogenase *
*No Wikipedia article

EC 1.1.3 With oxygen as acceptor[]

*No Wikipedia article

EC 1.1.4 With a disulfide as acceptor[]

  • EC 1.1.4.1: Now EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)
  • EC 1.1.4.2: Now EC 1.17.4.5, vitamin-K-epoxide reductase (warfarin-insensitive)

EC 1.1.5 With a quinone or similar compound as acceptor[]

EC 1.1.9 With a copper protein as acceptor[]

  • EC 1.1.9.1: alcohol dehydrogenase (azurin)

EC 1.1.98 With other, known, acceptors[]

  • EC 1.1.98.1: Now EC 1.1.9.1, alcohol dehydrogenase (azurin)
  • EC 1.1.98.2: glucose-6-phosphate dehydrogenase (coenzyme-F420)
  • EC 1.1.98.3: decaprenylphospho-β-D-ribofuranose 2-oxidase
  • EC 1.1.98.3: decaprenylphospho-β-D-ribofuranose 2-dehydrogenase *
  • EC 1.1.98.4: F420H2:quinone oxidoreductase *
  • EC 1.1.98.5: secondary-alcohol dehydrogenase (coenzyme-F420) *
  • EC 1.1.98.6: ribonucleoside-triphosphate reductase (formate) *
  • EC 1.1.98.7: serine-type anaerobic sulfatase-maturating enzyme *
*No Wikipedia article

EC 1.1.99 With unknown physiological acceptors[]

  • EC 1.1.99.1: choline dehydrogenase
  • EC 1.1.99.2: L-2-hydroxyglutarate dehydrogenase
  • EC 1.1.99.3: gluconate 2-dehydrogenase (acceptor)
  • EC 1.1.99.4: dehydrogluconate dehydrogenase
  • EC 1.1.99.5: now EC 1.1.5.3, glycerol-3-phosphate dehydrogenase
  • EC 1.1.99.6: D-2-hydroxy-acid dehydrogenase
  • EC 1.1.99.7: lactate—malate transhydrogenase
  • EC 1.1.99.8: Now EC 1.1.2.7, methanol dehydrogenase (cytochrome c) and EC 1.1.2.8, alcohol dehydrogenase (cytochrome c).
  • EC 1.1.99.9: pyridoxine 5-dehydrogenase
  • EC 1.1.99.10: Now EC 1.1.5.9, glucose 1-dehydrogenase (FAD, quinone)
  • EC 1.1.99.11: Now classified as EC 1.1.5.14, fructose 5-dehydrogenase
  • EC 1.1.99.12: sorbose dehydrogenase
  • EC 1.1.99.13: glucoside 3-dehydrogenase
  • EC 1.1.99.14: glycolate dehydrogenase
  • EC 1.1.99.15: Now EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]
  • EC 1.1.99.16: Now EC EC 1.1.5.4, malate dehydrogenase (quinone)
  • EC 1.1.99.17: Now EC 1.1.5.2, quinoprotein glucose dehydrogenase
  • EC 1.1.99.18: cellobiose dehydrogenase (acceptor)
  • EC 1.1.99.19: Now EC 1.17.99.4, uracil/thymine dehydrogenase
  • EC 1.1.99.20: alkan-1-ol dehydrogenase (acceptor)
  • EC 1.1.99.21: D-sorbitol dehydrogenase (acceptor)
  • EC 1.1.99.22: glycerol dehydrogenase (acceptor)
  • EC 1.1.99.23: Now EC 1.1.2.6, polyvinyl alcohol dehydrogenase (cytochrome)
  • EC 1.1.99.24: hydroxyacid-oxoacid transhydrogenase
  • EC 1.1.99.25: Now EC 1.1.5.8, quinate dehydrogenase (quinone),
  • EC 1.1.99.26: 3-hydroxycyclohexanone dehydrogenase
  • EC 1.1.99.27: (R)-pantolactone dehydrogenase (flavin)
  • EC 1.1.99.28: glucose-fructose oxidoreductase
  • EC 1.1.99.29: pyranose dehydrogenase (acceptor)
  • EC 1.1.99.30: 2-oxoacid reductase
  • EC 1.1.99.31: (S)-mandelate dehydrogenase
  • EC 1.1.99.32: L-sorbose 1-dehydrogenase
  • EC 1.1.99.33: Now EC 1.17.99.7, formate dehydrogenase (acceptor)
  • EC 1.1.99.34: now EC 1.1.98.2, glucose-6-phosphate dehydrogenase (coenzyme-F420)
  • EC 1.1.99.35: soluble quinoprotein glucose dehydrogenase
  • EC 1.1.99.36: alcohol dehydrogenase (nicotinoprotein)
  • EC 1.1.99.37: methanol dehydrogenase (nicotinoprotein)
  • EC 1.1.99.38: 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)
  • EC 1.1.99.39: D-2-hydroxyglutarate dehydrogenase
  • EC 1.1.99.40: (R)-2-hydroxyglutarate—pyruvate transhydrogenase *
  • EC 1.1.99.41: 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase *
  • EC 1.1.99.42: 4-pyridoxic acid dehydrogenase *
*No Wikipedia article

EC 1.2 Acting on the aldehyde or oxo group of donors[]

EC 1.2.1 With NAD+ or NADP+ as acceptor[]

* No Wikipedia article

EC 1.2.2 With a cytochrome as acceptor[]

  • EC 1.2.2.1: formate dehydrogenase (cytochrome)
  • EC 1.2.2.2: Now covered by EC 1.2.5.1, pyruvate dehydrogenase (quinone)
  • EC 1.2.2.3: Now EC 1.17.2.3, formate dehydrogenase (cytochrome-c-553)
  • EC 1.2.2.4: Now classified as EC 1.2.5.3, aerobic carbon monoxide dehydrogenase

EC 1.2.3 With oxygen as acceptor[]

  • EC 1.2.3.1: aldehyde oxidase
  • EC 1.2.3.2: Now EC 1.17.3.2, xanthine oxidase
  • EC 1.2.3.3: pyruvate oxidase
  • EC 1.2.3.4: oxalate oxidase
  • EC 1.2.3.5: glyoxylate oxidase
  • EC 1.2.3.6: pyruvate oxidase (CoA-acetylating)
  • EC 1.2.3.7: indole-3-acetaldehyde oxidase
  • EC 1.2.3.8: pyridoxal oxidase
  • EC 1.2.3.9: aryl-aldehyde oxidase
  • EC 1.2.3.10: deleted, activity due to EC 1.2.2.4 carbon-monoxide dehydrogenase (cytochrome b-561)
  • EC 1.2.3.11: retinal oxidase
  • EC 1.2.3.12: Now included with EC 1.2.3.1, aldehyde oxidase
  • EC 1.2.3.13: Now EC 1.14.13.82, vanillate monooxygenase
  • EC 1.2.3.14: Abscisic-aldehyde oxidase
  • EC 1.2.3.15: (methyl)glyoxal oxidase *
* No Wikipedia article

EC 1.2.4 With a disulfide as acceptor[]

  • EC 1.2.4.1: pyruvate dehydrogenase (acetyl-transferring)
  • EC 1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring)
  • EC 1.2.4.3: Now included with EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
  • EC 1.2.4.4: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

EC 1.2.5 With a quinone or similar compound as acceptor[]

  • EC 1.2.5.1: pyruvate dehydrogenase (quinone)
  • EC 1.2.5.2: aldehyde dehydrogenase (quinone) *
  • EC 1.2.5.3: aerobic carbon monoxide dehydrogenase *
*No Wikipedia article

EC 1.2.7 With an iron-sulfur protein as acceptor[]

  • EC 1.2.7.1: pyruvate synthase
  • EC 1.2.7.2: Now included with EC 1.2.7.1, pyruvate synthase.
  • EC 1.2.7.3: 2-oxoglutarate synthase
  • EC 1.2.7.4: anaerobic carbon monoxide dehydrogenase
  • EC 1.2.7.5: aldehyde ferredoxin oxidoreductase
  • EC 1.2.7.6: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
  • EC 1.2.7.7: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
  • EC 1.2.7.8: indolepyruvate ferredoxin oxidoreductase
  • EC 1.2.7.9: deleted, identical to EC 1.2.7.3, 2-oxoglutarate synthase
  • EC 1.2.7.10: oxalate oxidoreductase
  • EC 1.2.7.11: 2-oxoacid oxidoreductase (ferredoxin) *
  • EC 1.2.7.12: formylmethanofuran dehydrogenase *
*No Wikipedia article

EC 1.2.99: With unknown physiological acceptors[]

  • EC 1.2.99.1: Now EC 1.17.99.4, uracil/thymine dehydrogenase
  • EC 1.2.99.2: Now EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin)
  • EC 1.2.99.3: Now EC 1.2.5.2, aldehyde dehydrogenase (quinone)
  • EC 1.2.99.4: Now EC 1.2.98.1, formaldehyde dismutase
  • EC 1.2.99.5: Now EC 1.2.7.12, formylmethanofuran dehydrogenase
  • EC 1.2.99.6: carboxylate reductase
  • EC 1.2.99.7: aldehyde dehydrogenase (FAD-independent)
  • EC 1.2.99.8: glyceraldehyde dehydrogenase (FAD-containing) *
  • EC 1.2.99.9: Now EC 1.17.98.3, formate dehydrogenase (coenzyme F420)
  • EC 1.2.99.10: 4,4′-diapolycopenoate synthase *
*No Wikipedia article

EC 1.3 Acting on the CH-CH group of donors[]

EC 1.3.1 With NAD+ or NADP+ as acceptor[]

*No Wikipedia article

EC 1.3.2 With a cytochrome as acceptor[]

EC 1.3.3 With oxygen as acceptor[]

EC 1.3.5 With a quinone or related compound as acceptor[]

EC 1.3.7 With an iron-sulfur protein as acceptor[]

EC 1.3.8 With a flavin as acceptor[]

  • EC 1.3.8.1: short-chain acyl-CoA dehydrogenase
  • EC 1.3.8.2: 4,4′-diapophytoene desaturase (4,4′-diapolycopene-forming)
  • EC 1.3.8.3: (R)-benzylsuccinyl-CoA dehydrogenase
  • EC 1.3.8.4: isovaleryl-CoA dehydrogenase
  • EC 1.3.8.5: 2-methyl-branched-chain-enoyl-CoA reductase
  • EC 1.3.8.6: glutaryl-CoA dehydrogenase (ETF)
  • EC 1.3.8.7: medium-chain acyl-CoA dehydrogenase
  • EC 1.3.8.8: long-chain acyl-CoA dehydrogenase
  • EC 1.3.8.9: very-long-chain acyl-CoA dehydrogenase
  • EC 1.3.8.10: cyclohex-1-ene-1-carbonyl-CoA dehydrogenase *
  • EC 1.3.8.11: cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein) *
  • EC 1.3.8.12: (2S)-methylsuccinyl-CoA dehydrogenase *
  • EC 1.3.8.13: crotonobetainyl-CoA reductase *
  • EC 1.3.8.14: L-prolyl-[peptidyl-carrier protein] dehydrogenase *
  • EC 1.3.8.15: 3-(aryl)acrylate reductase *
  • EC 1.3.8.16: 2-amino-4-deoxychorismate dehydrogenase *
  • EC 1.3.8.17: dehydro coenzyme F420 reductase *
*No Wikipedia article

EC 1.3.98 With FMN acceptor[]

  • EC 1.3.98.1: dihydroorotate dehydrogenase (fumarate)
  • EC 1.3.98.2: Now EC 1.3.4.1, fumarate reductase (CoM/CoB)
  • EC 1.3.98.3: coproporphyrinogen dehydrogenase *
  • EC 1.3.98.4: 5a,11a-dehydrotetracycline reductase *
  • EC 1.3.98.5: hydrogen peroxide-dependent heme synthase *
  • EC 1.3.98.6: AdoMet-dependent heme synthase *
  • EC 1.3.98.7: [mycofactocin precursor peptide]-tyrosine decarboxylase
*No Wikipedia article

EC 1.3.99 With unknown physiological acceptors[]

  • EC 1.3.99.1: The activity is included in EC 1.3.5.1, succinate dehydrogenase (quinone)
  • EC 1.3.99.2: Now EC 1.3.8.1, butyryl-CoA dehydrogenase.
  • EC 1.3.99.3: now EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase
  • EC 1.3.99.4: 3-oxosteroid 1-dehydrogenase
  • EC 1.3.99.5: 3-oxo-5α-steroid 4-dehydrogenase (acceptor)
  • EC 1.3.99.6: 3-oxo-5β-steroid 4-dehydrogenase
  • EC 1.3.99.7: Now EC 1.3.8.6, glutaryl-CoA dehydrogenase
  • EC 1.3.99.8: 2-furoyl-CoA dehydrogenase
  • EC 1.3.99.9: Now EC 1.21.99.1, β-cyclopiazonate dehydrogenase
  • EC 1.3.99.10: Now EC 1.3.8.4, isovaleryl-CoA dehydrogenase
  • EC 1.3.99.11: transferred to EC 1.3.5.2, dihydroorotate dehydrogenase
  • EC 1.3.99.12: Now classified as EC 1.3.8.5, 2-methyl-branched-chain-enoyl-CoA reductase
  • EC 1.3.99.13: Now EC 1.3.8.8, long-chain-acyl-CoA dehydrogenase
  • EC 1.3.99.14: cyclohexanone dehydrogenase
  • EC 1.3.99.15: Now EC 1.3.7.8
  • EC 1.3.99.16: isoquinoline 1-oxidoreductase
  • EC 1.3.99.17: quinoline 2-oxidoreductase
  • EC 1.3.99.18: quinaldate 4-oxidoreductase
  • EC 1.3.99.19: quinoline-4-carboxylate 2-oxidoreductase
  • EC 1.3.99.20: Now EC 1.3.7.9, 4-hydroxybenzoyl-CoA reductase
  • EC 1.3.99.21: Now EC 1.3.8.3, (R)-benzylsuccinyl-CoA dehydrogenase
  • EC 1.3.99.22: Now EC 1.3.98.3, coproporphyrinogen dehydrogenase
  • EC 1.3.99.23: all-trans-retinol 13,14-reductase
  • EC 1.3.99.24: Now EC 1.3.8.16, 2-amino-4-deoxychorismate dehydrogenase
  • EC 1.3.99.25: carvone reductase
  • EC 1.3.99.26: all-trans-ζ-carotene desaturase
  • EC 1.3.99.27: 1-hydroxycarotenoid 3,4-desaturase
  • EC 1.3.99.28: phytoene desaturase (neurosporene-forming)
  • EC 1.3.99.29: phytoene desaturase (zeta-carotene-forming)
  • EC 1.3.99.30: phytoene desaturase (3,4-didehydrolycopene-forming)
  • EC 1.3.99.31: phytoene desaturase (lycopene-forming)
  • EC 1.3.99.32: glutaryl-CoA dehydrogenase (non-decarboxylating)
  • EC 1.3.99.33: urocanate reductase *
  • EC 1.3.99.34: Now classified as EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
  • EC 1.3.99.35: Now EC 1.3.7.15, chlorophyllide a reductase *
  • EC 1.3.99.36: cypemycin cysteine dehydrogenase (decarboxylating) *
  • EC 1.3.99.37: 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase *
  • EC 1.3.99.38: menaquinone-9 β-reductase *
  • EC 1.3.99.39: carotenoid φ-ring synthase *
  • EC 1.3.99.40: carotenoid χ-ring synthase *
*No Wikipedia article

EC 1.4 Acting on the CH-NH2 group of donors[]

EC 1.4.1 With NAD+ or NADP+ as acceptor[]

*No Wikipedia article

EC 1.4.2 With a cytochrome as acceptor[]

EC 1.4.3 With oxygen as acceptor[]

  • EC 1.4.3.1: D-aspartate oxidase
  • EC 1.4.3.2: L-amino-acid oxidase
  • EC 1.4.3.3: D-amino-acid oxidase
  • EC 1.4.3.4: monoamine oxidase
  • EC 1.4.3.5: pyridoxal 5′-phosphate synthase
  • EC 1.4.3.6: replaced by two enzymes, EC 1.4.3.21 (primary-amine oxidase) and EC 1.4.3.22 (diamine oxidase)
  • EC 1.4.3.7: D-glutamate oxidase
  • EC 1.4.3.8: ethanolamine oxidase
  • EC 1.4.3.9: Now included with EC 1.4.3.4 amine oxidase (flavin-containing)
  • EC 1.4.3.10: putrescine oxidase
  • EC 1.4.3.11: L-glutamate oxidase
  • EC 1.4.3.12: cyclohexylamine oxidase
  • EC 1.4.3.13: protein-lysine 6-oxidase
  • EC 1.4.3.14: L-lysine oxidase
  • EC 1.4.3.15: D-glutamate(D-aspartate) oxidase
  • EC 1.4.3.16: L-aspartate oxidase
  • EC 1.4.3.17: Now EC 1.3.3.10, tryptophan α,β-oxidase
  • EC 1.4.3.18: Not approved as the enzyme was shown to be a dehydrogenase and not an oxidase (see EC 1.5.99.12, cytokinin dehydrogenase)
  • EC 1.4.3.19: glycine oxidase
  • EC 1.4.3.20: L-lysine 6-oxidase
  • EC 1.4.3.21: primary-amine oxidase
  • EC 1.4.3.22: diamine oxidase
  • EC 1.4.3.23: 7-chloro-L-tryptophan oxidase
  • EC 1.4.3.24: pseudooxynicotine oxidase
  • EC 1.4.3.25: L-arginine oxidase *
  • EC 1.4.3.26: pre-mycofactocin synthase *
*No Wikipedia article

EC 1.4.4 With a disulfide as acceptor[]

  • EC 1.4.4.1: Now EC 1.21.4.1, D-proline reductase (dithiol)
  • EC 1.4.4.2: glycine dehydrogenase (aminomethyl-transferring)

EC 1.4.5 With a quinone or other compound as acceptor[]

EC 1.4.7 With an iron-sulfur protein as acceptor[]

  • EC 1.4.7.1: glutamate synthase (ferredoxin)

EC 1.4.9 With a copper protein as acceptor[]

  • EC 1.4.9.1: methylamine dehydrogenase (amicyanin)
  • EC 1.4.9.2: aralkylamine dehydrogenase (azurin)

EC 1.4.98 With tryptophan tryptophylquinone acceptors[]

  • EC 1.4.98.1: methylamine dehydrogenase (amicyanin)

EC 1.4.99 With unknown physiological acceptors[]

  • EC 1.4.99.1: Now lEC 1.4.99.6, D-arginine dehydrogenase
  • EC 1.4.99.2: taurine dehydrogenase
  • EC 1.4.99.3: Now EC 1.4.9.1, methylamine dehydrogenase (amicyanin)
  • EC 1.4.99.4: Now EC 1.4.9.2, aralkylamine dehydrogenase (azurin)
  • EC 1.4.99.5: glycine dehydrogenase (cyanide-forming)
  • EC 1.4.99.6: D-arginine dehydrogenase *
*No Wikipedia article

EC 1.5 Acting on the CH-NH group of donors[]

EC 1.5.1 With NAD+ or NADP+ as acceptor[]

*No Wikipedia article

EC 1.5.3 With oxygen as acceptor[]

*No Wikipedia article

EC 1.5.4 With a disulfide as acceptor[]

  • EC 1.5.4.1: pyrimidodiazepine synthase

EC 1.5.5 With a quinone or similar compound as acceptor[]

  • EC 1.5.5.1: electron-transferring-flavoprotein dehydrogenase
  • EC 1.5.5.2: proline dehydrogenase *
  • EC 1.5.5.3: hydroxyproline dehydrogenase *
*No Wikipedia article

EC 1.5.7 With an iron-sulfur protein as acceptor[]

  • EC 1.5.7.1: methylenetetrahydrofolate reductase (ferredoxin)
  • EC 1.5.7.2: coenzyme F420 oxidoreductase (ferredoxin) *
*No Wikipedia article

EC 1.5.8 With a flavin or flavoprotein as acceptor[]

  • EC 1.5.8.1: dimethylamine dehydrogenase
  • EC 1.5.8.2: trimethylamine dehydrogenase
  • EC 1.5.8.3: sarcosine dehydrogenase
  • EC 1.5.8.4: dimethylglycine dehydrogenase

EC 1.5.98 With other, known, physiological acceptors[]

  • EC 1.5.98.1: ethylenetetrahydromethanopterin dehydrogenase
  • EC 1.5.98.2: 5,10-methylenetetrahydromethanopterin reductase
  • EC 1.5.98.3: coenzyme F420:methanophenazine dehydrogenase

EC 1.5.99 With unknown physiological acceptors[]

  • EC 1.5.99.1: Now EC 1.5.8.3, sarcosine dehydrogenase
  • EC 1.5.99.2: Now EC 1.5.8.4, dimethylglycine dehydrogenase
  • EC 1.5.99.3: L-pipecolate dehydrogenase
  • EC 1.5.99.4: nicotine dehydrogenase
  • EC 1.5.99.5: methylglutamate dehydrogenase
  • EC 1.5.99.6: spermidine dehydrogenase
  • EC 1.5.99.7: Now EC 1.5.8.2, trimethylamine dehydrogenase
  • EC 1.5.99.8: Now EC 1.5.5.2, proline dehydrogenase
  • EC 1.5.99.9: transferred to EC 1.5.98.1, methylenetetrahydromethanopterin dehydrogenase
  • EC 1.5.99.10: Now EC 1.5.8.1, dimethylamine dehydrogenase
  • EC 1.5.99.11: transferred to EC 1.5.98.2, 5,10-methylenetetrahydromethanopterin reductase
  • EC 1.5.99.12: cytokinin dehydrogenase
  • EC 1.5.99.13: D-proline dehydrogenase
  • EC 1.5.99.14: 6-hydroxypseudooxynicotine dehydrogenase
  • EC 1.5.99.15: dihydromethanopterin reductase (acceptor) *
*No Wikipedia article

EC 1.6 Acting on NADH or NADPH[]

EC 1.6.1 With NAD or NADP as acceptor[]

EC 1.6.2 With a heme protein as acceptor[]

EC 1.6.3 With oxygen as acceptor[]

  • EC 1.6.3.1: NAD(P)H oxidase (H2O2-forming)
  • EC 1.6.3.2: NAD(P)H oxidase (H2O-forming) *
  • EC 1.6.3.3: NADH oxidase (H2O2-forming) *
  • EC 1.6.3.4: NADH oxidase (H2O-forming) *
  • EC 1.6.3.5: renalase *
*No Wikipedia article

EC 1.6.4 With a disulfide as acceptor (deleted sub-class)[]

  • EC 1.6.4.1: now EC 1.8.1.6 cystine reductase
  • EC 1.6.4.2: now EC 1.8.1.7 glutathione-disulfide reductase
  • EC 1.6.4.3: now EC 1.8.1.4 dihydrolipoyl dehydrogenase
  • EC 1.6.4.4: now EC 1.8.1.8 protein-disulfide reductase
  • EC 1.6.4.5: now EC 1.8.1.9 thioredoxin-disulfide reductase
  • EC 1.6.4.6: now EC 1.8.1.10 CoA-glutathione reductase
  • EC 1.6.4.7: now EC 1.8.1.11 asparagusate reductase
  • EC 1.6.4.8: now EC 1.8.1.12 trypanothione-disulfide reductase
  • EC 1.6.4.9: now EC 1.8.1.13 bis-γ-glutamylcystine reductase
  • EC 1.6.4.10: now EC 1.8.1.14 CoA-disulfide reductase

EC 1.6.5 With a quinone or similar compound as acceptor[]

  • EC 1.6.5.1: deleted
  • EC 1.6.5.2: NAD(P)H dehydrogenase (quinone)
  • EC 1.6.5.3: now EC 7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
  • EC 1.6.5.4: monodehydroascorbate reductase (NADH)
  • EC 1.6.5.5: NADPH:quinone reductase
  • EC 1.6.5.6: p-benzoquinone reductase (NADPH)
  • EC 1.6.5.7: 2-hydroxy-1,4-benzoquinone reductase
  • EC 1.6.5.8: Now EC 7.2.1.1, NADH:ubiquinone reductase (Na+-transporting)
  • EC 1.6.5.9: NADH:ubiquinone reductase (non-electrogenic)
  • EC 1.6.5.10: NADPH dehydrogenase (quinone)
  • EC 1.6.5.11: Identical to EC 1.6.5.9, NADH:quinone reductase (non-electrogenic) *
  • EC 1.6.5.12: demethylphylloquinone reductase *
*No Wikipedia article

EC 1.6.6 With a nitrogenous group as acceptor[]

  • EC 1.6.6.1: Now EC 1.7.1.1, nitrate reductase (NADH)
  • EC 1.6.6.2: Now EC 1.7.1.2, nitrate reductase [NAD(P)H]
  • EC 1.6.6.3: Now EC 1.7.1.3, nitrate reductase (NADPH)
  • EC 1.6.6.4: Now EC 1.7.1.4, nitrite reductase [NAD(P)H]
  • EC 1.6.6.5: Now EC 1.7.2.1, nitrite reductase (NO-forming)
  • EC 1.6.6.6: Now EC 1.7.1.5, hyponitrite reductase
  • EC 1.6.6.7: Now EC 1.7.1.6, azobenzene reductase
  • EC 1.6.6.8: Now EC 1.7.1.7, GMP reductase
  • EC 1.6.6.9: Now known to be catalysed by EC 1.7.2.3, trimethylamine-N-oxide reductase
  • EC 1.6.6.10: Now EC 1.7.1.9, nitroquinoline-N-oxide reductase]
  • EC 1.6.6.11: Now EC 1.7.1.10, hydroxylamine reductase (NADH)
  • EC 1.6.6.12: Now EC 1.7.1.11, 4-(dimethylamino)phenylazoxybenzene reductase
  • EC 1.6.6.13: Now EC 1.7.1.12, N-hydroxy-2-acetamidofluorene reductase

EC 1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)[]

  • EC 1.6.7.1: now EC 1.18.1.2 ferredoxin—NADP+ reductase
  • EC 1.6.7.2: now EC 1.18.1.1 rubredoxin—NAD+ reductase
  • EC 1.6.7.3: now EC 1.18.1.3 ferredoxin—NAD+ reductase

EC 1.6.8 With a flavin as acceptor (deleted sub-subclass)[]

  • EC 1.6.8.1: Now EC 1.5.1.29 FMN reductase
  • EC 1.6.8.2: Now EC 1.5.1.30 flavin reductase

EC 1.6.99 With unknown physiological acceptors[]

  • EC 1.6.99.1: NADPH dehydrogenase
  • EC 1.6.99.2: Now EC 1.6.5.2, NAD(P)H dehydrogenase (quinone
  • EC 1.6.99.3: The activity is covered by EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating)
  • EC 1.6.99.4: Now EC 1.18.1.2, ferredoxin—NADP+ reductase
  • EC 1.6.99.5: Now EC 1.6.5.11, NADH dehydrogenase (quinone)
  • EC 1.6.99.6: Now EC 1.6.5.10, NADPH dehydrogenase (quinone)
  • EC 1.6.99.7: Now EC 1.5.1.34, 6,7-dihydropteridine reductase
  • EC 1.6.99.8: Deleted
  • EC 1.6.99.9: Now EC 1.16.1.4, cob(II)alamin reductase
  • EC 1.6.99.10: included in EC 1.5.1.34, 6,7-dihydropteridine reductase
  • EC 1.6.99.11: Deleted
  • EC 1.6.99.12: Now EC 1.16.1.6, cyanocobalamin reductase (cyanide-eliminating)
  • EC 1.6.99.13: Now EC 1.16.1.7, ferric-chelate reductase

EC 1.7 Acting on other nitrogenous compounds as donors[]

EC 1.7.1 With NAD+ or NADP+ as acceptor[]

EC 1.7.2 With a cytochrome as acceptor[]

  • EC 1.7.2.1: nitrite reductase (NO-forming)
  • EC 1.7.2.2: nitrite reductase (cytochrome; ammonia-forming)
  • EC 1.7.2.3: trimethylamine-N-oxide reductase
  • EC 1.7.2.4: nitrous-oxide reductase
  • EC 1.7.2.5: nitric oxide reductase (cytochrome c)
  • EC 1.7.2.6: hydroxylamine dehydrogenase
  • EC 1.7.2.7: hydrazine synthase *
  • EC 1.7.2.8: hydrazine dehydrogenase *
*No Wikipedia article

EC 1.7.3 With oxygen as acceptor[]

*No Wikipedia article

EC 1.7.5 With a quinone or similar compound as acceptor[]

  • EC 1.7.5.1: nitrate reductase (quinone)
  • EC 1.7.5.2: nitric oxide reductase (menaquinol)

EC 1.7.6 With a nitrogenous group as acceptor[]

EC 1.7.7 With an iron-sulfur protein as acceptor[]

EC 1.7.99 With other acceptors[]

  • EC 1.7.99.1: hydroxylamine reductase
  • EC 1.7.99.2: deleted: reaction may have been due to the combined action of EC 1.7.99.6 nitrous-oxide reductase and EC 1.7.99.7 nitric-oxide reductase
  • EC 1.7.99.3: Now included with EC 1.7.2.1, nitrite reductase (NO-forming)
  • EC 1.7.99.4: Now EC 1.7.1.1, nitrate reductase (NADH), EC 1.7.1.2, nitrate reductase [NAD(P)H], EC 1.7.1.3, nitrate reductase (NADPH), EC 1.7.5.1, nitrate reductase (quinone), EC 1.7.7.2, nitrate reductase (ferredoxin) and EC 1.9.6.1, nitrate reductase (cytochrome)
  • EC 1.7.99.5: Now included with EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]
  • EC 1.7.99.6: Now EC 1.7.2.4 nitrous-oxide reductase
  • EC 1.7.99.7: Now EC 1.7.2.5 nitric oxide reductase (cytochrome c)
  • EC 1.7.99.8: hydroxylamine oxidoreductase
  • EC 1.7.99.8: Now classified as EC 1.7.2.8, hydrazine dehydrogenase

EC 1.8 Acting on a sulfur group of donors[]

EC 1.8.1 With NAD+ or NADP+ as acceptor[]

*No Wikipedia article

EC 1.8.2 With a cytochrome as acceptor[]

  • EC 1.8.2.1: sulfite dehydrogenase (cytochrome)
  • EC 1.8.2.2: thiosulfate dehydrogenase
  • EC 1.8.2.3: sulfide-cytochrome-c reductase (flavocytochrome c)
  • EC 1.8.2.4: dimethyl sulfide:cytochrome c2 reductase *
  • EC 1.8.2.5: thiosulfate reductase (cytochrome) *
  • EC 1.8.2.6: S-disulfanyl-L-cysteine oxidoreductase *
  • EC 1.8.2.7: thiocyanate desulfurase *
*No Wikipedia article

EC 1.8.3 With oxygen as acceptor[]

*No Wikipedia article

EC 1.8.4 With a disulfide as acceptor[]

*No Wikipedia article

EC 1.8.5 With a quinone or similar compound as acceptor[]

  • EC 1.8.5.1: glutathione dehydrogenase (ascorbate)
  • EC 1.8.5.2: thiosulfate dehydrogenase (quinone)
  • EC 1.8.5.3: respiratory dimethylsulfoxide reductase
  • EC 1.8.5.4: bacterial sulfide:quinone reductase
  • EC 1.8.5.5: thiosulfate reductase (quinone) *
  • EC 1.8.5.6: sulfite dehydrogenase (quinone) *
  • EC 1.8.5.7: glutathionyl-hydroquinone reductase *
  • EC 1.8.5.8: eukaryotic sulfide quinone oxidoreductase *
  • EC 1.8.5.9: protein dithiol:quinone oxidoreductase DsbB *
*No Wikipedia article

EC 1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)[]

EC 1.8.7 With an iron-sulfur protein as acceptor[]

*No Wikipedia article

EC 1.8.98 With other, known, acceptors[]

EC 1.8.99 With other acceptors[]

  • EC 1.8.99.1: Now covered by EC 1.8.1.2, assimilatory sulfite reductase (NADPH) and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin)
  • EC 1.8.99.2: adenylyl-sulfate reductase
  • EC 1.8.99.3: an in vitro artifact of EC 1.8.99.5, dissimilatory sulfite reductase
  • EC 1.8.99.4: Now EC 1.8.4.8, phosphoadenylyl-sulfate reductase (thioredoxin)
  • EC 1.8.99.5: dissimilatory sulfite reductase *
*No Wikipedia article

EC 1.9 Acting on a heme group of donors[]

EC 1.9.3 With oxygen as acceptor[]

  • EC 1.9.3.1: Now EC 7.1.1.9, cytochrome-c oxidase
  • EC 1.9.3.2: Now included with EC 1.7.2.1, nitrite reductase (NO-forming)

EC 1.9.6 With a nitrogenous group as acceptor[]

EC 1.9.98 With other, known, physiological acceptors[]

  • EC 1.9.98.1: iron—cytochrome-c reductase

EC 1.9.99 With other acceptors[]

  • EC 1.9.99.1: Now EC 1.9.98.1, iron—cytochrome-c reductase

EC 1.10 Acting on diphenols and related substances as donors[]

EC 1.10.1 With NAD+ or NADP+ as acceptor[]

  • EC 1.10.1.1: trans-acenaphthene-1,2-diol dehydrogenase

EC 1.10.2 With a cytochrome as acceptor[]

  • EC 1.10.2.1: The activity is covered by EC 7.2.1.3, ascorbate ferrireductase (transmembrane)
  • EC 1.10.2.2: Now EC 7.1.1.8, quinol—cytochrome-c reductase

EC 1.10.3 With oxygen as acceptor[]

  • EC 1.10.3.1: catechol oxidase
  • EC 1.10.3.2: laccase
  • EC 1.10.3.3: L-ascorbate oxidase
  • EC 1.10.3.4: o-aminophenol oxidase
  • EC 1.10.3.5: 3-hydroxyanthranilate oxidase
  • EC 1.10.3.6: rifamycin-B oxidase
  • EC 1.10.3.7: Now EC 1.21.3.4, sulochrin oxidase [(+)-bisdechlorogeodin-forming]
  • EC 1.10.3.8: Now EC 1.21.3.5, sulochrin oxidase [(-)-bisdechlorogeodin-forming]
  • EC 1.10.3.9: photosystem II
  • EC 1.10.3.10: Now EC 7.1.1.3, ubiquinol oxidase (H+-transporting)
  • EC 1.10.3.11: ubiquinol oxidase (non-electrogenic)
  • EC 1.10.3.12: Now EC 7.1.1.5, menaquinol oxidase (H +-transporting)
  • EC 1.10.3.13: Now EC 7.1.1.4, caldariellaquinol oxidase (H+-transporting)
  • EC 1.10.3.14: Now EC 7.1.1.7, ubiquinol oxidase (electrogenic, proton-motive force generating)
  • EC 1.10.3.15: grixazone synthase *
  • EC 1.10.3.16: dihydrophenazinedicarboxylate synthase *
  • EC 1.10.3.17: superoxide oxidase *
*No Wikipedia article

EC 1.10.5 With a quinone or related compound as acceptor[]

  • EC 1.10.5.1: ribosyldihydronicotinamide dehydrogenase (quinone)
*No Wikipedia article

EC 1.10.9 With a copper protein as acceptor[]

  • EC 1.10.9.1: Now EC 7.1.1.6, plastoquinol—plastocyanin reductase

EC 1.10.99 With unknown physiological acceptors[]

  • EC 1.10.99.1: Now EC 1.10.9.1 plastoquinol—plastocyanin reductase
  • EC 1.10.99.2: Now EC 1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone)
  • EC 1.10.99.3: Now EC 1.23.5.1 violaxanthin de-epoxidase

EC 1.11 Acting on a peroxide as acceptor[]

EC 1.11.1 Peroxidases[]

*No Wikipedia article

EC 1.11.2 Peroxygenase[]

*No Wikipedia article

EC 1.12 Acting on hydrogen as donor[]

EC 1.12.1 With NAD+ or NADP+ as acceptor[]

*No Wikipedia article

EC 1.12.2 With a cytochrome as acceptor[]

EC 1.12.5 With a quinone or similar compound as acceptor[]

  • EC 1.12.5.1: hydrogen:quinone oxidoreductase

EC 1.12.7 With an iron-sulfur protein as acceptor[]

  • EC 1.12.7.1: Now EC 1.12.7.2, ferredoxin hydrogenase
  • EC 1.12.7.2: ferredoxin hydrogenase

EC 1.12.98 With other known acceptors[]

EC 1.12.99 With unknown physiological acceptors[]

  • EC 1.12.99.1: Now EC 1.12.98.1, coenzyme F420 hydrogenase
  • EC 1.12.99.2: Now shown to be two enzymes, EC 1.12.98.3, Methanosarcina-phenazine hydrogenase and EC 1.8.98.1, CoB—CoM heterodisulfide reductase
  • EC 1.12.99.3: Now EC 1.12.5.1, hydrogen:quinone oxidoreductase
  • EC 1.12.99.4: Now EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase
  • EC 1.12.99.5: Identical to EC 1.13.11.47, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase
  • EC 1.12.99.6: hydrogenase (acceptor)

EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)[]

EC 1.13.11 With incorporation of two atoms of oxygen[]

*No Wikipedia article

EC 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)[]

*No Wikipedia article

EC 1.13.99 Miscellaneous[]

EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen[]

EC 1.14.1 With NADH or NADPH as one donor (deleted sub-subclass)[]

  • EC 1.14.1.1: now EC 1.14.14.1, unspecific monooxygenase
  • EC 1.14.1.2: now EC 1.14.13.9, kynurenine 3-monooxygenase
  • EC 1.14.1.3: deleted, covered by EC 1.14.99.7, squalene monooxygenase and EC 5.4.99.7, lanosterol synthase
  • EC 1.14.1.4: now EC 1.14.99.2, kynurenine 7,8-hydroxylase
  • EC 1.14.1.5: now EC 1.14.13.5; imidazoleacetate 4-monooxygenase
  • EC 1.14.1.6: now EC 1.14.15.4, steroid 11β-monooxygenase
  • EC 1.14.1.7: now EC 1.14.99.9, steroid 17α-monooxygenase
  • EC 1.14.1.8: now EC 1.14.99.10, steroid 21-monooxygenase
  • EC 1.14.1.9: deleted
  • EC 1.14.1.10: now EC 1.14.99.11 estradiol 6β-monooxygenase
  • EC 1.14.1.11: deleted

EC 1.14.2 With ascorbate as one donor (deleted sub-subclass)[]

  • EC 1.14.2.1: now EC 1.14.17.1, dopamine β-monooxygenase
  • EC 1.14.2.2: now EC 1.13.11.27, 4-hydroxyphenylpyruvate dioxygenase

EC 1.14.3 With reduced pteridine as one donor (deleted sub-subclass)[]

  • EC 1.14.3.1: now EC 1.14.16.1, phenylalanine 4-monooxygenase

EC 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors[]

EC 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor[]

  • EC 1.14.12.1: anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
  • EC 1.14.12.2: Now EC 1.14.13.35 anthranilate 3-monooxygenase (deaminating)
  • EC 1.14.12.3: benzene 1,2-dioxygenase
  • EC 1.14.12.4: EC 1.14.13.242, 3-hydroxy-2-methylpyridinecarboxylate monooxygenase
  • EC 1.14.12.5: Now EC .14.13.241, 5-pyridoxate monooxygenase
  • EC 1.14.12.6: Now EC 1.14.13.66, 2-hydroxycyclohexanone 2-monooxygenase
  • EC 1.14.12.7: phthalate 4,5-dioxygenase
  • EC 1.14.12.8: 4-sulfobenzoate 3,4-dioxygenase
  • EC 1.14.12.9: 4-chlorophenylacetate 3,4-dioxygenase
  • EC 1.14.12.10: benzoate 1,2-dioxygenase
  • EC 1.14.12.11: toluene dioxygenase
  • EC 1.14.12.12: naphthalene 1,2-dioxygenase
  • EC 1.14.12.13: 2-halobenzoate 1,2-dioxygenase
  • EC 1.14.12.14: 2-aminobenzenesulfonate 2,3-dioxygenase
  • EC 1.14.12.15: terephthalate 1,2-dioxygenase
  • EC 1.14.12.16: 2-hydroxyquinoline 5,6-dioxygenase
  • EC 1.14.12.17: nitric oxide dioxygenase
  • EC 1.14.12.18: biphenyl 2,3-dioxygenase
  • EC 1.14.12.19: 3-phenylpropionate dioxygenase
  • EC 1.14.12.20: Now classified as EC 1.14.15.17, pheophorbide a oxygenase.
  • EC 1.14.12.21: Now EC 1.14.13.208, benzoyl-CoA 2,3-epoxidase
  • EC 1.14.12.22: carbazole 1,9a-dioxygenase
  • EC 1.14.12.23: nitroarene dioxygenase *
  • EC 1.14.12.24: 2,4-dinitrotoluene dioxygenase *
  • EC 1.14.12.25: p-cumate 2,3-dioxygenase *
  • EC 1.14.12.26: chlorobenzene dioxygenase *
*No Wikipedia article

EC 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor[]

  • EC 1.14.13.1: salicylate 1-monooxygenase
  • EC 1.14.13.2: 4-hydroxybenzoate 3-monooxygenase
  • EC 1.14.13.3: Now EC 1.14.14.9, 4-hydroxyphenylacetate 3-monooxygenase
  • EC 1.14.13.4: melilotate 3-monooxygenase
  • EC 1.14.13.5: imidazoleacetate 4-monooxygenase
  • EC 1.14.13.6: orcinol 2-monooxygenase
  • EC 1.14.13.7: phenol 2-monooxygenase
  • EC 1.14.13.8: flavin-containing monooxygenase
  • EC 1.14.13.9: kynurenine 3-monooxygenase
  • EC 1.14.13.10: 2,6-dihydroxypyridine 3-monooxygenase
  • EC 1.14.13.11: Now EC 1.14.14.91, trans-cinnamate 4-monooxygenase
  • EC 1.14.13.12: Now EC 1.14.14.92, benzoate 4-monooxygenase
  • EC 1.14.13.13: Now classified as EC 1.14.15.18, calcidiol 1-monooxygenase
  • EC 1.14.13.14: trans-cinnamate 2-monooxygenase
  • EC 1.14.13.15: Now EC 1.14.15.15, cholestanetriol 26-monooxygenase
  • EC 1.14.13.16: cyclopentanone monooxygenase
  • EC 1.14.13.17: Now EC 1.14.14.23, cholesterol 7α-monooxygenase
  • EC 1.14.13.18: 4-hydroxyphenylacetate 1-monooxygenase
  • EC 1.14.13.19: taxifolin 8-monooxygenase
  • EC 1.14.13.20: 2,4-dichlorophenol 6-monooxygenase
  • EC 1.14.13.21: Now EC 1.14.14.82, flavonoid 3′-monooxygenase
  • EC 1.14.13.22: cyclohexanone monooxygenase
  • EC 1.14.13.23: 3-hydroxybenzoate 4-monooxygenase
  • EC 1.14.13.24: 3-hydroxybenzoate 6-monooxygenase
  • EC 1.14.13.25: methane monooxygenase (soluble)
  • EC 1.14.13.26: Now classified as EC 1.14.18.4, phosphatidylcholine 12-monooxygenase
  • EC 1.14.13.27: 4-aminobenzoate 1-monooxygenase
  • EC 1.14.13.28: Now EC 1.14.14.93, 3,9-dihydroxypterocarpan 6a-monooxygenase
  • EC 1.14.13.29: 4-nitrophenol 2-monooxygenase
  • EC 1.14.13.30: Now EC 1.14.14.94, leukotriene-B4 20-monooxygenase
  • EC 1.14.13.31: 2-nitrophenol 2-monooxygenase
  • EC 1.14.13.32: albendazole monooxygenase
  • EC 1.14.13.33: 4-hydroxybenzoate 3-monooxygenase (NAD(P)H)
  • EC 1.14.13.34: leukotriene-E4 20-monooxygenase
  • EC 1.14.13.35: anthranilate 3-monooxygenase (deaminating)
  • EC 1.14.13.36: Now EC 1.14.14.96, 5-O-(4-coumaroyl)-D-quinate 3′-monooxygenase
  • EC 1.14.13.37: Now EC 1.14.14.97, methyltetrahydroprotoberberine 14-monooxygenase
  • EC 1.14.13.38: anhydrotetracycline monooxygenase
  • EC 1.14.13.39: nitric-oxide synthase
  • EC 1.14.13.40: anthraniloyl-CoA monooxygenase
  • EC 1.14.13.41: Now EC 1.14.14.36, tyrosine N-monooxygenase
  • EC 1.14.13.42: The activity is covered by EC 1.14.13.68, 4-hydroxyphenylacetaldehyde oxime monooxygenase
  • EC 1.14.13.43: questin monooxygenase
  • EC 1.14.13.44: 2-hydroxybiphenyl 3-monooxygenase
  • EC 1.14.13.45: Now EC 1.14.18.2, CMP-N-acetylneuraminate monooxygenase
  • EC 1.14.13.46: (-)-menthol monooxygenase
  • EC 1.14.13.47: Now EC 1.14.14.99, (S)-limonene 3-monooxygenase
  • EC 1.14.13.48: Now classified as EC 1.14.14.51, (S)-limonene 6-monooxygenase
  • EC 1.14.13.49: Now classified as EC 1.14.14.52, (S)-limonene 7-monooxygenase
  • EC 1.14.13.50: pentachlorophenol monooxygenase
  • EC 1.14.13.51: 6-oxocineole dehydrogenase
  • EC 1.14.13.52: Now EC 1.14.14.88, isoflavone 3′-hydroxylase
  • EC 1.14.13.53: Now EC 1.14.14.89, 4′-methoxyisoflavone 2′-hydroxylase
  • EC 1.14.13.54: ketosteroid monooxygenase
  • EC 1.14.13.55: Now EC 1.14.14.98, protopine 6-monooxygenase
  • EC 1.14.13.56: Now EC 1.14.14.100, dihydrosanguinarine 10-monooxygenase
  • EC 1.14.13.57: Now EC 1.14.14.101, dihydrochelirubine 12-monooxygenase
  • EC 1.14.13.58: benzoyl-CoA 3-monooxygenase
  • EC 1.14.13.59: L-lysine N 6-monooxygenase (NADPH)
  • EC 1.14.13.60: Now included with EC 1.14.13.100, 25-hydroxycholesterol 7α-hydroxylase
  • EC 1.14.13.61: 2-hydroxyquinoline 8-monooxygenase
  • EC 1.14.13.62: 4-hydroxyquinoline 3-monooxygenase
  • EC 1.14.13.63: 3-hydroxyphenylacetate 6-hydroxylase
  • EC 1.14.13.64: 4-hydroxybenzoate 1-hydroxylase
  • EC 1.14.13.65: deleted
  • EC 1.14.13.66: 2-hydroxycyclohexanone 2-monooxygenase
  • EC 1.14.13.67: Now EC 1.14.14.55, quinine 3-monooxygenase
  • EC 1.14.13.68: Now EC 1.14.14.37, 4-hydroxyphenylacetaldehyde oxime monooxygenase
  • EC 1.14.13.69: alkene monooxygenase
  • EC 1.14.13.70: Now EC 1.14.14.154, sterol 14α-demethylase
  • EC 1.14.13.71: Now EC 1.14.14.102, N-methylcoclaurine 3′-monooxygenase
  • EC 1.14.13.72: Now classified as EC 1.14.18.9, methylsterol monooxygenase
  • EC 1.14.13.73: Now EC 1.14.14.103, tabersonine 16-hydroxylase
  • EC 1.14.13.74: Now EC 1.14.14.85, 7-deoxyloganin 7-hydroxylase
  • EC 1.14.13.75: Now EC 1.14.14.104, vinorine hydroxylase
  • EC 1.14.13.76: Now EC 1.14.14.105, taxane 10β-hydroxylase
  • EC 1.14.13.77: Now EC 1.14.14.106, taxane 13α-hydroxylase
  • EC 1.14.13.78: Now EC 1.14.14.86, ent-kaurene monooxygenase
  • EC 1.14.13.79: Now EC 1.14.14.107, ent-kaurenoic acid oxidase
  • EC 1.14.13.80: Now classified as EC 1.14.14.53, (R)-limonene 6-monooxygenase
  • EC 1.14.13.81: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
  • EC 1.14.13.82: vanillate monooxygenase
  • EC 1.14.13.83: precorrin-3B synthase
  • EC 1.14.13.84: 4-hydroxyacetophenone monooxygenase
  • EC 1.14.13.85: Now EC 1.14.14.135, glyceollin synthase
  • EC 1.14.13.86: The activity is covered by EC 1.14.14.87, 2-hydroxyisoflavanone synthase
  • EC 1.14.13.87: Now EC 1.14.14.140, licodione synthase]
  • EC 1.14.13.88: Now EC 1.14.14.81, flavanoid 3,5-hydroxylase
  • EC 1.14.13.89: Now EC 1.14.14.90, isoflavone 2-hydroxylase
  • EC 1.14.13.90: Now EC 1.14.15.21, zeaxanthin epoxidase
  • EC 1.14.13.91: Now EC 1.14.14.136, deoxysarpagine hydroxylase
  • EC 1.14.13.92: phenylacetone monooxygenase
  • EC 1.14.13.93: Now EC 1.14.14.137, (+)-abscisic acid 8-hydroxylase
  • EC 1.14.13.94: Now EC 1.14.14.138, lithocholate 6β-hydroxylase
  • EC 1.14.13.95: Now included with EC 1.14.14.139, 5β-cholestane-3α,7α-diol 12α-hydroxylase
  • EC 1.14.13.96: Now EC 1.14.14.139, 5β-cholestane-3α,7α-diol 12α-hydroxylase
  • EC 1.14.13.97: Now EC 1.14.14.57, taurochenodeoxycholate 6α-hydroxylase
  • EC 1.14.13.98: Now EC 1.14.14.25, cholesterol 24-hydroxylase
  • EC 1.14.13.99: Now EC 1.14.14.26, 24-hydroxycholesterol 7α-hydroxylase
  • EC 1.14.13.100: Now classified as EC 1.14.14.29, 25/26-hydroxycholesterol 7α-hydroxylase
  • EC 1.14.13.101: senecionine N-oxygenase
  • EC 1.14.13.102: Now EC 1.14.14.141, psoralen synthase
  • EC 1.14.13.103: Now EC 1.14.14.142, 8-dimethylallylnaringenin 2-hydroxylase
  • EC 1.14.13.104: Now EC 1.14.14.143, (+)-menthofuran synthase
  • EC 1.14.13.105: monocyclic monoterpene ketone monooxygenase
  • EC 1.14.13.106: now classified as EC 1.14.15.39, epi-isozizaene 5-monooxygenase.
  • EC 1.14.13.107: limonene 1,2-monooxygenase
  • EC 1.14.13.108: Now EC 1.14.14.144, abieta-7,13-diene hydroxylase
  • EC 1.14.13.109: Now EC 1.14.14.145, abieta-7,13-dien-18-ol hydroxylase
  • EC 1.14.13.110: Now EC 1.14.14.146, geranylgeraniol 18-hydroxylase
  • EC 1.14.13.111: methanesulfonate monooxygenase
  • EC 1.14.13.112: Now EC 1.14.14.147, 3-epi-6-deoxocathasterone 23-monooxygenase
  • EC 1.14.13.113: FAD-dependent urate hydroxylase
  • EC 1.14.13.114: 6-hydroxynicotinate 3-monooxygenase
  • EC 1.14.13.115: Now EC 1.14.14.148, angelicin synthase
  • EC 1.14.13.116: Now EC 1.14.14.174, geranylhydroquinone 3-hydroxylase
  • EC 1.14.13.117: Now EC 1.14.14.39, isoleucine N-monooxygenase
  • EC 1.14.13.118: Now EC 1.14.14.38, valine N-monooxygenase
  • EC 1.14.13.119: Now EC 1.14.14.149, 5-epiaristolochene 1,3-dihydroxylase
  • EC 1.14.13.120: Now EC 1.14.14.150, costunolide synthase
  • EC 1.14.13.121: Now EC 1.14.14.151, premnaspirodiene oxygenase
  • EC 1.14.13.122: chlorophyllide-a oxygenase
  • EC 1.14.13.123: Now EC 1.14.14.95, germacrene A hydroxylase
  • EC 1.14.13.124: now classified as EC 1.14.14.40, phenylalanine N-monooxygenase
  • EC 1.14.13.125: Now EC 1.14.14.156, tryptophan N-monooxygenase
  • EC 1.14.13.126: Now EC 1.14.15.16, vitamin D3 24-hydroxylase
  • EC 1.14.13.127: 3-(3-hydroxyphenyl)propanoate hydroxylase
  • EC 1.14.13.128: 7-methylxanthine demethylase
  • EC 1.14.13.129: Now EC 1.14.15.24, β-carotene 3-hydroxylase
  • EC 1.14.13.130: pyrrole-2-carboxylate monooxygenase
  • EC 1.14.13.131: dimethyl-sulfide monooxygenase
  • EC 1.14.13.132: Now EC 1.14.14.17, squalene monooxygenase
  • EC 1.14.13.133: Now EC 1.14.15.32, pentalenene oxygenase
  • EC 1.14.13.134: Now EC 1.14.14.152, β-amyrin 11-oxidase
  • EC 1.14.13.135: 1-hydroxy-2-naphthoate hydroxylase
  • EC 1.14.13.136: Now EC 1.14.14.87, 2-hydroxyisoflavanone synthase
  • EC 1.14.13.137: Now EC 1.14.14.153, indole-2-monooxygenase
  • EC 1.14.13.138: Now EC 1.14.14.157, indolin-2-one monooxygenase
  • EC 1.14.13.139: Now EC 1.14.14.109, 3-hydroxyindolin-2-one monooxygenase
  • EC 1.14.13.140: Now EC 1.14.14.110, 2-hydroxy-1,4-benzoxazin-3-one monooxygenase.
  • EC 1.14.13.141: Now EC 1.14.15.29, cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
  • EC 1.14.13.142: Now EC 1.14.15.30, 3-ketosteroid 9α-monooxygenase
  • EC 1.14.13.143: Now EC 1.14.14.76 ent-isokaurene C2/C3-hydroxylase
  • EC 1.14.13.144: Now EC 1.14.14.111, 9β-pimara-7,15-diene oxidase
  • EC 1.14.13.145: Now EC 1.14.14.112, ent-cassa-12,15-diene 11-hydroxylase
  • EC 1.14.13.146: taxoid 14β-hydroxylase
  • EC 1.14.13.147: taxoid 7β-hydroxylase
  • EC 1.14.13.148: trimethylamine monooxygenase
  • EC 1.14.13.149: phenylacetyl-CoA 1,2-epoxidase
  • EC 1.14.13.150: Now EC 1.14.14.113, α-humulene 10-hydroxylase
  • EC 1.14.13.151: Now EC 1.14.14.84, linalool 8-monooxygenase
  • EC 1.14.13.152: Now EC 1.14.14.83, geraniol 8-hydroxylase
  • EC 1.14.13.153: (+)-sabinene 3-hydroxylase
  • EC 1.14.13.154: erythromycin 12-hydroxylase
  • EC 1.14.13.155: α-pinene monooxygenase
  • EC 1.14.13.156: Now EC 1.14.14.133, 1,8-cineole 2-endo-monooxygenase
  • EC 1.14.13.157: Now EC 1.14.14.56, 1,8-cineole 2-exo-monooxygenase
  • EC 1.14.13.158: Now EC 1.14.14.114, amorpha-4,11-diene 12-monooxygenase
  • EC 1.14.13.159: Now EC 1.14.14.24, vitamin D 25-hydroxylase
  • EC 1.14.13.160: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase
  • EC 1.14.13.161: (+)-camphor 6-exo-hydroxylase
  • EC 1.14.13.162: Now EC 1.14.14.108, 2,5-diketocamphane 1,2-monooxygenase
  • EC 1.14.13.163: 6-hydroxy-3-succinoylpyridine 3-monooxygenase
  • EC 1.14.13.164: withdrawn: see EC 1.13.11.65, carotenoid isomerooxygenase
  • EC 1.14.13.165: Now classified as EC 1.14.14.47, nitric-oxide synthase (flavodoxin)
  • EC 1.14.13.166: 4-nitrocatechol 4-monooxygenase
Most of the entries from here on have no Wikipedia articles
  • EC 1.14.13.167: 4-nitrophenol 4-monooxygenase
  • EC 1.14.13.168: indole-3-pyruvate monooxygenase
  • EC 1.14.13.169: Now EC 1.14.18.5, sphingolipid C4-monooxygenase
  • EC 1.14.13.170: pentalenolactone D synthase
  • EC 1.14.13.171: neopentalenolactone D synthase
  • EC 1.14.13.172: salicylate 5-hydroxylase
  • EC 1.14.13.173: Now EC 1.14.14.115, 11-oxo-β-amyrin 30-oxidase
  • EC 1.14.13.174: Now EC 1.14.14.116, averantin hydroxylase
  • EC 1.14.13.175: Now EC 1.14.14.117, aflatoxin B synthase
  • EC 1.14.13.176: Now EC 1.14.14.118, tryprostatin B 6-hydroxylase
  • EC 1.14.13.177: Now EC 1.14.14.119, fumitremorgin C monooxygenase
  • EC 1.14.13.178: methylxanthine N 1-demethylase
  • EC 1.14.13.179: methylxanthine N 3-demethylase
  • EC 1.14.13.180: aklavinone 12-hydroxylase
  • EC 1.14.13.181: 13-deoxydaunorubicin hydroxylase
  • EC 1.14.13.182: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
  • EC 1.14.13.183: Now EC 1.14.14.120, dammarenediol 12-hydroxylase
  • EC 1.14.13.184: Now EC 1.14.14.121, protopanaxadiol 6-hydroxylase
  • EC 1.14.13.185: Now EC 1.14.15.33, pikromycin synthase
  • EC 1.14.13.186: Now EC 1.14.15.34, 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
  • EC 1.14.13.187: L-evernosamine nitrososynthase
  • EC 1.14.13.188: Now EC 1.14.15.35, 6-deoxyerythronolide B hydroxylase
  • EC 1.14.13.189: 5-methyl-1-naphthoate 3-hydroxylase
  • EC 1.14.13.190: Now EC 1.14.14.175, ferruginol synthase
  • EC 1.14.13.191: Now EC 1.14.14.70, ent-sandaracopimaradiene 3-hydroxylase
  • EC 1.14.13.192: Now EC 1.14.14.122, oryzalexin E synthase
  • EC 1.14.13.193: Now EC 1.14.14.123, oryzalexin D synthase
  • EC 1.14.13.194: Now EC 1.14.14.78, phylloquinone ω-hydroxylase
  • EC 1.14.13.195: L-ornithine N 5-monooxygenase (NADPH)
  • EC 1.14.13.196: L-ornithine N 5-monooxygenase [NAD(P)H]
  • EC 1.14.13.197: Now EC 1.14.14.124, dihydromonacolin L hydroxylase
  • EC 1.14.13.198: Now EC 1.14.14.125, monacolin L hydroxylase
  • EC 1.14.13.199: Now EC 1.14.14.79, docosahexaenoic acid ω-hydroxylase
  • EC 1.14.13.200: tetracenomycin A2 monooxygenase-dioxygenase
  • EC 1.14.13.201: Now EC 1.14.14.126, β-amyrin 28-monooxygenase
  • EC 1.14.13.202: Now EC 1.14.14.127, methyl farnesoate epoxidase
  • EC 1.14.13.203: Now EC 1.14.14.128, farnesoate epoxidase
  • EC 1.14.13.204: Now EC 1.14.14.129, long-chain acyl-CoA ω-monooxygenase
  • EC 1.14.13.205: Now EC 1.14.14.80, long-chain fatty acid ω-monooxygenase
  • EC 1.14.13.206: Now EC 1.14.14.130, laurate 7-monooxygenase
  • EC 1.14.13.207: Now EC 1.14.14.31, ipsdienol synthase
  • EC 1.14.13.208: benzoyl-CoA 2,3-epoxidase
  • EC 1.14.13.209: salicyloyl-CoA 5-hydroxylase
  • EC 1.14.13.210: 4-methyl-5-nitrocatechol 5-monooxygenase
  • EC 1.14.13.211: rifampicin monooxygenase
  • EC 1.14.13.212: 1,3,7-trimethyluric acid 5-monooxygenase
  • EC 1.14.13.213: Now EC 1.14.14.131, bursehernin 5-monooxygenase
  • EC 1.14.13.214: Now EC 1.14.14.132, (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase
  • EC 1.14.13.215: protoasukamycin 4-monooxygenase
  • EC 1.14.13.216: asperlicin C monooxygenase
  • EC 1.14.13.217: protodeoxyviolaceinate monooxygenase
  • EC 1.14.13.218: 5-methylphenazine-1-carboxylate 1-monooxygenase
  • EC 1.14.13.219: resorcinol 4-hydroxylase (NADPH)
  • EC 1.14.13.220: resorcinol 4-hydroxylase (NADH)
  • EC 1.14.13.221: Now EC 1.14.15.28, cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
  • EC 1.14.13.222: aurachin C monooxygenase/isomerase
  • EC 1.14.13.223: 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase
  • EC 1.14.13.224: violacein synthase
  • EC 1.14.13.225: F-actin monooxygenase
  • EC 1.14.13.226: acetone monooxygenase (methyl acetate-forming)
  • EC 1.14.13.227: propane 2-monooxygenase
  • EC 1.14.13.228: jasmonic acid 12-hydroxylase
  • EC 1.14.13.229: tert-butyl alcohol monooxygenase
  • EC 1.14.13.230: butane monooxygenase (soluble)
  • EC 1.14.13.231: tetracycline 11a-monooxygenase
  • EC 1.14.13.232: 6-methylpretetramide 4-monooxygenase
  • EC 1.14.13.233: 4-hydroxy-6-methylpretetramide 12a-monooxygenase
  • EC 1.14.13.234: 5a,11a-dehydrotetracycline 5-monooxygenase
  • EC 1.14.13.235: indole-3-acetate monooxygenase
  • EC 1.14.13.236: toluene 4-monooxygenase
  • EC 1.14.13.237: aliphatic glucosinolate S-oxygenase
  • EC 1.14.13.238: dimethylamine monooxygenase
  • EC 1.14.13.239: carnitine monooxygenase
  • EC 1.14.13.240: 2-polyprenylphenol 6-hydroxylase
  • EC 1.14.13.241: 5-pyridoxate monooxygenase
  • EC 1.14.13.242: 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
  • EC 1.14.13.243: toluene 2-monooxygenase
  • EC 1.14.13.244: phenol 2-monooxygenase (NADH)
  • EC 1.14.13.245: assimilatory dimethylsulfide S-monooxygenase
  • EC 1.14.13.246: 4β-methylsterol monooxygenase
  • EC 1.14.13.247: stachydrine N-demethylase

EC 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen[]

Most of the entries from here on have no Wikipedia articles

EC 1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen[]

Most entries from here on have no Wikipedia articles
  • EC 1.14.15.13: pulcherriminic acid synthase
  • EC 1.14.15.14: methyl-branched lipid ω-hydroxylase
  • EC 1.14.15.15: cholestanetriol 26-monooxygenase
  • EC 1.14.15.16: vitamin D3 24-hydroxylase
  • EC 1.14.15.17: pheophorbide a oxygenase
  • EC 1.14.15.18: calcidiol 1-monooxygenase
  • EC 1.14.15.19: C-19 steroid 1α-hydroxylase
  • EC 1.14.15.20: heme oxygenase (biliverdin-producing, ferredoxin)
  • EC 1.14.15.21: zeaxanthin epoxidase
  • EC 1.14.15.22: vitamin D 1,25-hydroxylase
  • EC 1.14.15.23: chloroacetanilide N-alkylformylase
  • EC 1.14.15.24: β-carotene 3-hydroxylase
  • EC 1.14.15.25: p-cymene methyl-monooxygenase
  • EC 1.14.15.26: toluene methyl-monooxygenase
  • EC 1.14.15.27: β-dihydromenaquinone-9 ω-hydroxylase
  • EC 1.14.15.28: cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
  • EC 1.14.15.29: cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
  • EC 1.14.15.30: 3-ketosteroid 9α-monooxygenase
  • EC 1.14.15.31: 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
  • EC 1.14.15.32: pentalenene oxygenase
  • EC 1.14.15.33: pikromycin synthase
  • EC 1.14.15.34: 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
  • EC 1.14.15.35: 6-deoxyerythronolide B hydroxylase
  • EC 1.14.15.36: sterol 14α-demethylase (ferredoxin)
  • EC 1.14.15.37: luteothin monooxygenase
  • EC 1.14.15.38: N,N-dimethyl phenylurea N-demethylase
  • EC 1.14.15.39: epi-isozizaene 5-monooxygenase

EC 1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor[]

  • EC 1.14.16.1: phenylalanine 4-monooxygenase
  • EC 1.14.16.2: tyrosine 3-monooxygenase
  • EC 1.14.16.3: withdrawn owing to insufficient evidence (anthranilate 3-monooxygenase)
  • EC 1.14.16.4: tryptophan 5-monooxygenase
  • EC 1.14.16.5: alkylglycerol monooxygenase
  • EC 1.14.16.6: mandelate 4-monooxygenase
  • EC 1.14.16.7: phenylalanine 3-monooxygenase

EC 1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor[]

  • EC 1.14.17.1: dopamine β-monooxygenase
  • EC |1.14.17.2: deleted, now included with EC 1.14.18.1 monophenol monooxygenase
  • EC 1.14.17.3: peptidylglycine monooxygenase
  • EC 1.14.17.4: aminocyclopropanecarboxylate oxidase

EC 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor[]

  • EC 1.14.18.1: tyrosinase
  • EC 1.14.18.2: CMP-N-acetylneuraminate monooxygenase
  • EC 1.14.18.3: methane monooxygenase (particulate)
  • EC 1.14.18.4: phosphatidylcholine 12-monooxygenase *
  • EC 1.14.18.5: sphingolipid C4-monooxygenase *
  • EC 1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase *
  • EC 1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase *
  • EC 1.14.18.8: Now included with EC 1.14.14.139, 5β-cholestane-3α,7α-diol 12α-hydroxylase
  • EC 1.14.18.9: 4α-methylsterol monooxygenase *
  • EC 1.14.18.10: plant 4,4-dimethylsterol C-4α-methyl-monooxygenase *
  • EC 1.14.18.11: plant 4α-monomethylsterol monooxygenase *
  • EC 1.14.18.12: 2-hydroxy fatty acid dioxygenase *
*No Wikipedia article

EC 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water[]

  • EC 1.14.19.1: stearoyl-CoA 9-desaturase
  • EC 1.14.19.2: stearoyl-[acyl-carrier-protein] 9-desaturase
  • EC 1.14.19.3: linoleoyl-CoA desaturase
  • EC 1.14.19.4: acyl-lipid (11-3)-desaturase
  • EC 1.14.19.5: acyl-CoA 11-(Z)-desaturase
  • EC 1.14.19.6: acyl-CoA (9+3)-desaturase
  • EC 1.14.19.7: Now EC 1.11.1.23, (S)-2-hydroxypropylphosphonic acid epoxidase
Most of the entries from here on have no Wikipedia articles

EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated[]

  • EC 1.14.20.1: deacetoxycephalosporin-C synthase
  • EC 1.14.20.2: Now EC 1.14.11.59, 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase
  • EC 1.14.20.3: (5R)-carbapenem-3-carboxylate synthase *
  • EC 1.14.20.4: anthocyanidin synthase *
  • EC 1.14.20.5: flavone synthase I *
  • EC 1.14.20.6: flavonol synthase *
  • EC 1.14.20.7: 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) *
  • EC 1.14.20.8: (–)-deoxypodophyllotoxin synthase *
  • EC 1.14.20.9: L-tyrosine isonitrile desaturase *
  • EC 1.14.20.10: L-tyrosine isonitrile desaturase/decarboxylase *
  • EC 1.14.20.11: 3-[(Z)-2-isocyanoethenyl]-1H-indole synthase *
  • EC 1.14.20.12: 3-[(E)-2-isocyanoethenyl]-1H-indole synthase *
  • EC 1.14.20.13: 6β-hydroxyhyoscyamine epoxidase *
  • EC 1.14.20.14: hapalindole-type alkaloid chlorinase *
  • EC 1.14.20.15: L-threonyl-[L-threonyl-carrier protein] 4-chlorinase *
*No Wikipedia article

EC 1.14.21 With NADH or NADPH as one donor}}, and the other dehydrogenated[]

  • EC 1.14.21.1: Now EC 1.14.19.64, (S)-stylopine synthase
  • EC 1.14.21.2: Now EC 1.14.19.65, (S)-cheilanthifoline synthase
  • EC 1.14.21.3: Now EC 1.14.19.66, berbamunine synthase
  • EC 1.14.21.4: Now EC 1.14.19.67, salutaridine synthase
  • EC 1.14.21.5: Now EC 1.14.19.68, (S)-canadine synthase
  • EC 1.14.21.6: Now EC 1.14.19.20, Δ7-sterol 5(6)-desaturase
  • EC 1.14.21.7: Now EC 1.14.19.69, biflaviolin synthase
  • EC 1.14.21.8: Now EC 1.14.19.63, pseudobaptigenin synthase
  • EC 1.14.21.9: Now EC 1.14.19.70, mycocyclosin synthase *
  • EC 1.14.21.10: Now EC 1.14.19.71, fumitremorgin C synthase *
  • EC 1.14.21.11: Now EC 1.14.19.72, (–)-pluviatolide synthase *
  • EC 1.14.21.12: Now EC 1.14.19.73, (S)-nandinine synthase *
*No Wikipedia article

EC 1.14.99 Miscellaneous[]

Most of the entries from here on have no Wikipedia article
  • EC 1.14.99.48: heme oxygenase (staphylobilin-producing)
  • EC 1.14.99.49: Now EC 1.14.15.31, 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
  • EC 1.14.99.50: γ-glutamyl hercynylcysteine S-oxide synthase
  • EC 1.14.99.51: hercynylcysteine S-oxide synthase
  • EC 1.14.99.52: L-cysteinyl-L-histidinylsulfoxide synthase
  • EC 1.14.99.53: lytic chitin monooxygenase
  • EC 1.14.99.54: lytic cellulose monooxygenase (C1-hydroxylating)
  • EC 1.14.99.55: lytic starch monooxygenase
  • EC 1.14.99.56: lytic cellulose monooxygenase (C4-dehydrogenating)
  • EC 1.14.99.57: heme oxygenase (mycobilin-producing)
  • EC 1.14.99.58: heme oxygenase (biliverdin-IX-β and δ-forming)
  • EC 1.14.99.59: tryptamine 4-monooxygenase
  • EC 1.14.99.60: 3-demethoxyubiquinol 3-hydroxylase
  • EC 1.14.99.61: cyclooctat-9-en-7-ol 5-monooxygenase
  • EC 1.14.99.62: cyclooctatin synthase
  • EC 1.14.99.63: β-carotene 4-ketolase
  • EC 1.14.99.64: zeaxanthin 4-ketolase
  • EC 1.14.99.65: 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase
  • EC 1.14.99.66: [histone H3]-N 6,N 6-dimethyl-L-lysine4 FAD-dependent demethylase
  • EC 1.14.99.67: α-N-dichloroacetyl-p-aminophenylserinol N-oxygenase
  • EC 1.14.99.68: 4-aminobenzoate N-oxygenase
  • EC 1.14.99.69: tRNA 2-(methylsulfanyl)-N 6-isopentenyladenosine37 hydroxylase

EC 1.15 Acting on superoxide as acceptor[]

EC 1.15.1[]

EC 1.16 Oxidizing metal ions[]

EC 1.16.1 With NAD+ or NADP+ as acceptor[]

  • EC 1.16.1.1: mercury(II) reductase
  • EC 1.16.1.2: diferric-transferrin reductase
  • EC 1.16.1.3: deleted since no specific enzyme catalysing this activity has been identified
  • EC 1.16.1.4: cob(II)alamin reductase
  • EC 1.16.1.5: deleted since the enzyme the entry was based on was later shown to be EC 1.2.1.51, pyruvate dehydrogenase (NADP+).
  • EC 1.16.1.6: cyanocobalamin reductase (cyanide-eliminating)
  • EC 1.16.1.7: ferric-chelate reductase
  • EC 1.16.1.8: [methionine synthase] reductase
  • EC 1.16.1.9: ferric-chelate reductase (NADPH)
  • EC 1.16.1.10: ferric-chelate reductase [NAD(P)H] *
*No Wikipedia article

EC 1.16.3 With oxygen as acceptor[]

*No Wikipedia article

EC 1.16.5 With a quinone or similar compound as acceptor[]

  • EC 1.16.5.1: Now EC 7.2.1.3, ascorbate ferrireductase (transmembrane)

EC 1.16.8 With a flavin as acceptor[]

  • EC 1.16.8.1: activity now known to be catalyzed by EC 2.5.1.17, corrinoid adenosyltransferase

EC 1.16.9 With a copper protein as acceptor[]

EC 1.16.98 With other, known, physiological acceptors[]

  • EC 1.16.98.1: Now EC 1.16.9.1 iron:rusticyanin reductase

EC 1.16.99 With unknown physiological acceptors[]

  • EC 1.16.99.1: [Co(II) methylated amine-specific corrinoid protein] reductase

EC 1.17 Acting on CH or CH2 groups[]

EC 1.17.1 With NAD or NADP as acceptor[]

  • EC 1.17.1.1: CDP-4-dehydro-6-deoxyglucose reductase
  • EC 1.17.1.2: now classified as EC 1.17.7.4, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
  • EC 1.17.1.3: leucoanthocyanidin reductase
  • EC 1.17.1.4: xanthine dehydrogenase
  • EC 1.17.1.5: nicotinate dehydrogenase
  • EC 1.17.1.6: Now EC 1.17.99.5, bile-acid 7α-dehydroxylase. It is now known that FAD is the acceptor and not NAD+ as was thought previously
  • EC 1.17.1.7: Now EC 1.2.1.91, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
  • EC 1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase *
  • EC 1.17.1.9: formate dehydrogenase *
  • EC 1.17.1.10: formate dehydrogenase (NADP+) *
  • EC 1.17.1.11: formate dehydrogenase (NAD+, ferredoxin) *
*No Wikipedia article

EC 1.17.2 With a cytochrome as acceptor[]

  • EC 1.17.2.1: nicotinate dehydrogenase (cytochrome)
  • EC 1.17.2.2: lupanine 17-hydroxylase (cytochrome c)
  • EC 1.17.2.3: formate dehydrogenase (cytochrome-c-553) *
*No Wikipedia article

EC 1.17.3 With oxygen as acceptor[]

*No Wikipedia article

EC 1.17.4 With a disulfide as acceptor[]

  • EC 1.17.4.1: ribonucleoside-diphosphate reductase
  • EC 1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)
  • EC 1.17.4.3: transferred to EC 1.17.7.1, (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.
  • EC 1.17.4.4: vitamin-K-epoxide reductase (warfarin-sensitive) *
  • EC 1.17.4.5: vitamin-K-epoxide reductase (warfarin-insensitive) *
*No Wikipedia article

EC 1.17.5 With a quinone or similar compound as acceptor[]

*No Wikipedia article

EC 1.17.7 With an iron-sulfur protein as acceptor[]

  • EC 1.17.7.1: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)
  • EC 1.17.7.2: 7-hydroxymethyl chlorophyll a reductase
  • EC 1.17.7.3: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) *
  • EC 1.17.7.4: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase *
*No Wikipedia article

EC 1.17.98 With other, known, physiological acceptors[]

  • EC 1.17.98.1: bile-acid 7α-dehydroxylase. Now known to be catalyzed by multiple enzymes.
  • EC 1.17.98.2: bacteriochlorophyllide c C-71-hydroxylase *
  • EC 1.17.98.3: formate dehydrogenase (coenzyme F420) *
  • EC 1.17.98.4: formate dehydrogenase (hydrogenase) *
*No Wikipedia article

EC 1.17.99 With unknown physiological acceptors[]

No Wikipedia article for any of these
  • EC 1.17.99.1: Now EC 1.17.9.1, 4-methylphenol dehydrogenase (hydroxylating)
  • EC 1.17.99.2: ethylbenzene hydroxylase
  • EC 1.17.99.3: 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase
  • EC 1.17.99.4: uracil/thymine dehydrogenase
  • EC 1.17.99.5: Now classified as EC 1.17.98.1, bile-acid 7α-dehydroxylase
  • EC 1.17.99.6: epoxyqueuosine reductase
  • EC 1.17.99.7: Now classified as EC 1.17.98.4, formate dehydrogenase (hydrogenase)
  • EC 1.17.99.8: limonene dehydrogenase
  • EC 1.17.99.9: heme a synthase
  • EC 1.17.99.10: steroid C-25 hydroxylase
  • EC 1.17.99.11: 3-oxo-Δ1-steroid hydratase/dehydrogenase

EC 1.18 Acting on iron-sulfur proteins as donors[]

EC 1.18.1 With NAD+ or NADP+ as acceptor[]

EC 1.18.2 With dinitrogen as acceptor (deleted sub-subclass)[]

  • EC 1.18.2.1: now EC 1.18.6.1, nitrogenase

EC 1.18.3 With H+ as acceptor (deleted sub-subclass)[]

  • EC 1.18.3.1: Now EC 1.12.7.2, ferredoxin hydrogenase

EC 1.18.6 With dinitrogen as acceptor[]

*No Wikipedia article

EC 1.18.96 With other, known, acceptors (deleted sub-subclass)[]

  • EC 1.18.96.1: Now EC 1.15.1.2, superoxide reductase

EC 1.18.99 With H+ as acceptor (deleted sub-subclass)[]

  • EC 1.18.99.1: Now EC 1.12.7.2, ferredoxin hydrogenase

EC 1.19 Acting on reduced flavodoxin as donor[]

EC 1.19.1 With NAD+ or NADP+ as acceptor[]

  • EC 1.19.1.1: flavodoxin—NADP+ reductase

EC 1.19.6 With dinitrogen as acceptor[]

EC 1.20 Acting on phosphorus or arsenic in donors[]

EC 1.20.1 Acting on phosphorus or arsenic in donors, with NAD+ as acceptor[]

EC 1.20.2 Acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor[]

  • EC 1.20.2.1: arsenate reductase (cytochrome c)

EC 1.20.4 Acting on phosphorus or arsenic in donors, with disulfide as acceptor[]

*No Wikipedia article

EC 1.20.9 With a copper protein as acceptor[]

  • EC 1.20.9.1: arsenate reductase (azurin)

EC 1.20.98 With other, known acceptors[]

  • EC 1.20.98.1: Now EC 1.20.9.1, arsenate reductase (azurin)

EC 1.20.99 With unknown physiological acceptors[]

EC 1.21 Catalysing the reaction X-H + Y-H = X-Y[]

EC 1.21.3 With oxygen as acceptor[]

EC 1.21.4 With a disulfide as acceptor[]

*No Wikipedia article

EC 1.21.98 With other, known, physiological acceptors[]

  • EC 1.21.98.1: cyclic dehypoxanthinyl futalosine synthase *
  • EC 1.21.98.2: dichlorochromopyrrolate synthase *
  • EC 1.21.98.3: anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase *
  • EC 1.21.98.4: PqqA peptide cyclase *
*No Wikipedia article

EC 1.21.99 With unknown physiological acceptors[]

*No Wikipedia article

EC 1.22 Acting on halogen in donors[]

EC 1.22.1 With NAD+ or NADP+ as acceptor[]

  • EC 1.22.1.1: Now EC 1.21.1.1, iodotyrosine deiodinase

EC 1.23 Reducing C-O-C group as acceptor[]

EC 1.23.1 With NADH or NADPH as donor[]

  • EC 1.23.1.1: (+)-pinoresinol reductase *
  • EC 1.23.1.2: (+)-lariciresinol reductase *
  • EC 1.23.1.3: (–)-pinoresinol reductase *
  • EC 1.23.1.4: (–)-lariciresinol reductase *
*No Wikipedia article

EC 1.97 Other oxidoreductases[]

EC 1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses[]

  • EC 1.97.1.1: chlorate reductase
  • EC 1.97.1.2: pyrogallol hydroxytransferase
  • EC 1.97.1.3: Now EC 1.12.98.4, sulfhydrogenase, since hydrogen is known to be the electron donor
  • EC 1.97.1.4: [formate-C-acetyltransferase]-activating enzyme
  • EC 1.97.1.5: Now EC 1.20.4.1, arsenate reductase (glutaredoxin
  • EC 1.97.1.6: Now EC 1.20.99.1, arsenate reductase (donor)
  • EC 1.97.1.7: Now EC 1.20.4.2, methylarsonate reductase
  • EC 1.97.1.8: Now EC 1.21.99.5, tetrachloroethene reductive dehalogenase
  • EC 1.97.1.9: selenate reductase
  • EC 1.97.1.10: Now EC 1.21.99.4 thyroxine 5′-deiodinase
  • EC 1.97.1.11: Now EC 1.21.99.3 thyroxine 5-deiodinase.
  • EC 1.97.1.12: photosystem I

EC 1.98 Enzymes using H2 as reductant (deleted subclass)[]

EC 1.98.1.1: Now EC 1.12.7.2, ferredoxin hydrogenase

EC 1.99 Other enzymes using O2 as oxidant[]

EC 1.99.1 Hydroxylases (now covered by EC 1.14)[]

  • EC 1.99.1.1: deleted, Now EC 1.12.7.2, ferredoxin hydrogenase
  • EC 1.99.1.2: deleted, Now EC 1.14.16.1, phenylalanine 4-monooxygenase
  • EC 1.99.1.3: deleted, nicotinate 6-hydroxylase
  • EC 1.99.1.4: deleted, tryptophan 5-hydroxylase
  • EC 1.99.1.5: deleted, Now EC 1.14.13.9, kynurenine 3-monooxygenase
  • EC 1.99.1.6: deleted, steroid 11α-hydroxylase
  • EC 1.99.1.7: deleted, Now EC 1.14.15.4, steroid 11β-monooxygenase
  • EC 1.99.1.8: deleted, steroid 6β-hydroxylase
  • EC 1.99.1.9: deleted, Now EC 1.14.99.9, steroid 17α-monooxygenase
  • EC 1.99.1.10: deleted, steroid 19-hydroxylase
  • EC 1.99.1.11: deleted, Now EC 1.14.99.10, steroid 21-monooxygenase
  • EC 1.99.1.12: deleted, alkoxyaryl hydroxylase
  • EC 1.99.1.13: deleted, covered by EC 1.14.99.7 (squalene monooxygenase) and by EC 5.4.99.7 (lanosterol synthase)
  • EC 1.99.1.14: deleted, Now EC 1.13.11.27, 4-hydroxyphenylpyruvate dioxygenase

EC 1.99.2 Oxygenases (now covered by EC 1.13)[]

  • EC 1.99.2.1: deleted, now EC 1.13.11.12, lipoxygenase
  • EC 1.99.2.2: deleted, now EC 1.13.11.1, catechol 1,2-dioxygenase
  • EC 1.99.2.3: deleted, now EC 1.13.11.3, protocatechuate 3,4-dioxygenase
  • EC 1.99.2.4: deleted, now EC 1.13.11.4, gentisate 1,2-dioxygenase
  • EC 1.99.2.5: deleted, now EC 1.13.11.5, homogentisate 1,2-dioxygenase
  • EC 1.99.2.6: deleted, now EC 1.13.99.1, inositol oxygenase

References[]

  1. ^ "ExplorEnz – The Enzyme Database".
  2. ^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37: D593–D597. doi:10.1093/nar/gkn582.
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