Glutathione—CoA-glutathione transhydrogenase
| glutathione-CoA—glutathione transhydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.8.4.3 | ||||||||
| CAS no. | 37256-48-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a glutathione—CoA-glutathione transhydrogenase (EC 1.8.4.3) is an enzyme that catalyzes the chemical reaction
- CoA + glutathione disulfide CoA-glutathione + glutathione
Thus, the two substrates of this enzyme are CoA and glutathione disulfide, whereas its two products are and glutathione.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is CoA:glutathione-disulfide oxidoreductase. Other names in common use include glutathione-coenzyme A glutathione disulfide transhydrogenase, glutathione-coenzyme A glutathione disulfide transhydrogenase, glutathione coenzyme A-glutathione transhydrogenase, glutathione:coenzyme A-glutathione transhydrogenase, coenzyme A:oxidized-glutathione oxidoreductase, and coenzyme A:glutathione-disulfide oxidoreductase. This enzyme participates in cysteine metabolism and glutathione metabolism.
References[]
- Chang SH, Wilken DR (1966). "Participation of the unsymmetrical disulfide of coenzyme A and glutathione in an enzymatic sulfhydryl-disulfide interchange. I Partial purification and properties of the bovine kidney enzyme". J. Biol. Chem. 241 (18): 4251–60. PMID 5924646.
- EC 1.8.4
- Enzymes of unknown structure
- Oxidoreductase stubs