List of EC numbers (EC 3)

From Wikipedia, the free encyclopedia

This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.[1] The database is developed and maintained by Andrew McDonald.[2]

EC 3.1: Acting on Ester Bonds[]

EC 3.1.1: Carboxylic Ester Hydrolases[]

*No Wikipedia article

EC 3.1.2: Thioester Hydrolases[]

  • EC 3.1.2.1: acetyl-CoA hydrolase
  • EC 3.1.2.2: palmitoyl-CoA hydrolase
  • EC 3.1.2.3: succinyl-CoA hydrolase
  • EC 3.1.2.4: 3-hydroxyisobutyryl-CoA hydrolase
  • EC 3.1.2.5: hydroxymethylglutaryl-CoA hydrolase
  • EC 3.1.2.6: hydroxyacylglutathione hydrolase
  • EC 3.1.2.7: glutathione thiolesterase
  • EC 3.1.2.8: Now included with EC 3.1.2.6 hydroxyacylglutathione hydrolase
  • EC 3.1.2.9: S-acetoacetylhydrolipoate hydrolase deleted
  • EC 3.1.2.10: formyl-CoA hydrolase
  • EC 3.1.2.11: acetoacetyl-CoA hydrolase
  • EC 3.1.2.12: S-formylglutathione hydrolase
  • EC 3.1.2.13: S-succinylglutathione hydrolase
  • EC 3.1.2.14: oleoyl-[acyl-carrier-protein] hydrolase
  • EC 3.1.2.15: covered by EC 3.4.19.12, ubiquitinyl hydrolase 1
  • EC 3.1.2.16: citrate lyase deacetylase
  • EC 3.1.2.17: (S)-methylmalonyl-CoA hydrolase
  • EC 3.1.2.18: ADP-dependent short-chain-acyl-CoA hydrolase
  • EC 3.1.2.19: ADP-dependent medium-chain-acyl-CoA hydrolase
  • EC 3.1.2.20: acyl-CoA hydrolase
  • EC 3.1.2.21: dodecanoyl-(acyl-carrier-protein) hydrolase
  • EC 3.1.2.22: palmitoyl[protein] hydrolase
  • EC 3.1.2.23: 4-hydroxybenzoyl-CoA thioesterase
  • EC 3.1.2.24: transferred entry now EC 3.13.1.3, 2′-hydroxybiphenyl-2-sulfinate desulfinase.
  • EC 3.1.2.25: phenylacetyl-CoA hydrolase
  • EC 3.1.2.26: Now EC 2.8.3.25, bile acid CoA transferase
  • EC 3.1.2.27: choloyl-CoA hydrolase
  • EC 3.1.2.28: 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
  • EC 3.1.2.29: fluoroacetyl-CoA thioesterase
  • EC 3.1.2.30: (3S)-malyl-CoA thioesterase *
  • EC 3.1.2.31: dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase *
  • EC 3.1.2.32: 2-aminobenzoylacetyl-CoA thioesterase *
*No Wikipedia article

EC 3.1.3: Phosphoric Monoester Hydrolases[]

* No Wikipedia article

EC 3.1.4: Phosphoric Diester Hydrolases[]

  • EC 3.1.4.1: phosphodiesterase I
  • EC 3.1.4.2: glycerophosphocholine phosphodiesterase
  • EC 3.1.4.3: lecithinase C
  • EC 3.1.4.4: phospholipase D
  • EB 3.1.4.5: Now EC 3.1.21.1, deoxyribonuclease I
  • EB 3.1.4.6: Now EC 3.1.22.1, deoxyribonuclease II
  • EB 3.1.4.7: Now EC 3.1.31.1, micrococcal nuclease
  • EB 3.1.4.8: Now EC 3.1.27.3, ribonuclease T1
  • EB 3.1.4.9: Now EC 3.1.30.2, Serratia marcescens nuclease
  • EB 3.1.4.10: Now EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase
  • EC 3.1.4.11: phosphoinositide phospholipase C
  • EC 3.1.4.12: sphingomyelin phosphodiesterase
  • EC 3.1.4.13: serine-ethanolaminephosphate phosphodiesterase
  • EC 3.1.4.14: [acyl-carrier-protein] phosphodiesterase
  • EB 3.1.4.15: transferred to EC 2.7.7.89, adenylyl-[glutamateammonia ligase] phosphorylase
  • EC 3.1.4.16: 2′,3′-cyclic-nucleotide 2′-phosphodiesterase
  • EC 3.1.4.17: 3′,5′-cyclic-nucleotide phosphodiesterase
  • EB 3.1.4.18: Now EC 3.1.16.1, spleen exonuclease
  • EB 3.1.4.19: Now EC 3.1.13.3, oligonucleotidase
  • EB 3.1.4.20: Now EC 3.1.13.1, exoribonuclease II
  • EB 3.1.4.21: Now EC 3.1.30.1, Aspergillus nuclease S1
  • EB 3.1.4.22: Now EC 3.1.27.5, pancreatic ribonuclease
  • EB 3.1.4.23: Now EC 3.1.27.1, ribonuclease T2
  • EB 3.1.4.24: deleted
  • EB 3.1.4.25: Now EC 3.1.11.1, exodeoxyribonuclease I
  • EB 3.1.4.26: deleted
  • EB 3.1.4.27: Now EC 3.1.11.2, exodeoxyribonuclease III
  • EB 3.1.4.28: Now EC 3.1.11.3, exodeoxyribonuclease (lambda-induced)
  • EB 3.1.4.29: deleted
  • EB 3.1.4.30: Now EC 3.1.21.2, deoxyribonuclease IV (phage-T4-induced)
  • EB 3.1.4.31: now EC 3.1.11.4
  • EB 3.1.4.32: deleted
  • EB 3.1.4.33: deleted
  • EB 3.1.4.34: deleted
  • EC 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase
  • EC 3.1.4.36: now with EC 3.1.4.43
  • EC 3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
  • EC 3.1.4.38: glycerophosphocholine cholinephosphodiesterase
  • EC 3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase
  • EC 3.1.4.40: CMP-N-acylneuraminate phosphodiesterase
  • EC 3.1.4.41: sphingomyelin phosphodiesterase D
  • EC 3.1.4.42: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase
  • EC 3.1.4.43: glycerophosphoinositol inositolphosphodiesterase
  • EC 3.1.4.44: glycerophosphoinositol glycerophosphodiesterase
  • EC 3.1.4.45: N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase
  • EC 3.1.4.46: glycerophosphodiester phosphodiesterase
  • EB 3.1.4.47: Now EC 4.6.1.14, glycosylphosphatidylinositol diacylglycerol-lyase
  • EC 3.1.4.48: dolichylphosphate-glucose phosphodiesterase
  • EC 3.1.4.49: dolichylphosphate-mannose phosphodiesterase
  • EC 3.1.4.50: glycosylphosphatidylinositol phospholipase D
  • EC 3.1.4.51: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase
  • EC 3.1.4.52: cyclic-guanylate-specific phosphodiesterase
  • EC 3.1.4.53: 3′,5′-cyclic-AMP phosphodiesterase
  • EC 3.1.4.54: N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
  • EC 3.1.4.55: phosphoribosyl 1,2-cyclic phosphate phosphodiesterase *
  • EC 3.1.4.56: 7,8-dihydroneopterin 2′,3′-cyclic phosphate phosphodiesterase
  • EC 3.1.4.57: phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase *
  • EC 3.1.4.58: RNA 2′,3′-cyclic 3′-phosphodiesterase *
  • EC 3.1.4.59: cyclic-di-AMP phosphodiesterase *
  • EC 3.1.4.60: pApA phosphodiesterase *
  • EC 3.1.4.61: cyclic 2,3-diphosphoglycerate hydrolase *
*No Wikipedia article

EC 3.1.5: Triphosphoric Monoester Hydrolases[]

EC 3.1.6: Sulfuric Ester Hydrolases[]

*No Wikipedia article

EC 3.1.7: Diphosphoric Monoester Hydrolases[]

*No Wikipedia article

EC 3.1.8: Phosphoric Triester Hydrolases[]

  • EC 3.1.8.1: aryldialkylphosphatase
  • EC 3.1.8.2: diisopropyl-fluorophosphatase

EC 3.1.11: Exodeoxyribonucleases Producing 5'-Phosphomonoesters[]

  • EC 3.1.11.1: exodeoxyribonuclease I
  • EC 3.1.11.2: exodeoxyribonuclease III
  • EC 3.1.11.3: exodeoxyribonuclease (lambda-induced)
  • EC 3.1.11.4: exodeoxyribonuclease (phage SP3-induced)
  • EC 3.1.11.5: exodeoxyribonuclease V
  • EC 3.1.11.6: exodeoxyribonuclease VII
  • EC 3.1.11.7: Now EC 3.6.1.71, adenosine-5′-diphospho-5′-[DNA] diphosphatase
  • EC 3.1.11.8: Now EC 3.6.1.70, guanosine-5′-diphospho-5′-[DNA] diphosphatase

EC 3.1.13: Exoribonucleases Producing 5'-Phosphomonoesters[]

EC 3.1.14: Exoribonucleases Producing 3'-Phosphomonoesters[]

EC 3.1.15: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters[]

EC 3.1.16: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters[]

EC 3.1.21: Endodeoxyribonucleases Producing 5'-Phosphomonoesters[]

  • EC 3.1.21.1: deoxyribonuclease I
  • EC 3.1.21.2: deoxyribonuclease IV
  • EC 3.1.21.3: type I site-specific deoxyribonuclease
  • EC 3.1.21.4: type II site-specific deoxyribonuclease
  • EC 3.1.21.5: type III site-specific deoxyribonuclease
  • EC 3.1.21.6: CC-preferring endodeoxyribonuclease
  • EC 3.1.21.7: deoxyribonuclease V
  • EC 3.1.21.8: T4 deoxyribonuclease II *
  • EC 3.1.21.9: T4 deoxyribonuclease IV *
  • EC 3.1.21.10: crossover junction endodeoxyribonuclease *
*No Wikipedia article

EC 3.1.22: Endodeoxyribonucleases Producing 3'-Phosphomonoesters[]

EC 3.1.23: and EC 3.1.24 now EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5[]

Deleted sub-subclasses.

EC 3.1.25: Site-Specific Endodeoxyribonucleases Specific for Altered Bases[]

  • EC 3.1.25.1: deoxyribonuclease (pyrimidine dimer)
  • EC 3.1.25.2: Now EC 4.2.99.18, DNA-(apurinic or apyrimidinic site) lyase

EC 3.1.26: Endoribonucleases Producing 5'-Phosphomonoesters[]

EC 3.1.27: Endoribonucleases Producing 3'-Phosphomonoesters[]

  • EC 3.1.27.1: Now EC 4.6.1.19, ribonuclease T2, since the primary reaction is that of a lyase
  • EC 3.1.27.2: Now EC 4.6.1.22, Bacillus subtilis ribonuclease, since the reaction catalysed is that of a lyase
  • EC 3.1.27.3: Now EC 4.6.1.24, ribonuclease T1, since the primary reaction is that of a lyase
  • EC 3.1.27.4: Now EC 4.6.1.20, ribonuclease U2, since the primary reaction is that of a lyase
  • EC 3.1.27.5: Now EC 4.6.1.18, pancreatic ribonuclease.
  • EC 3.1.27.6: Now EC 4.6.1.21, Enterobacter ribonuclease, since the primary reaction is that of a lyase
  • EC 3.1.27.7: ribonuclease F
  • EC 3.1.27.8: ribonuclease V
  • EC 3.1.27.9: Now EC 4.6.1.16, tRNA-intron lyase
  • EC 3.1.27.10: Now EC 4.6.1.23, ribotoxin,

EC 3.1.30: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters[]

EC 3.1.31: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters[]

EC 3.2: Glycosylases[]

EC 3.2.1: Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds[]

*No Wikipedia article

EC 3.2.2: Hydrolysing N-Glycosyl Compounds[]

*No Wikipedia article

EC 3.2.3: Hydrolysing S-Glycosyl Compounds[]

Deleted sub-subclass

EC 3.3: Acting on Ether Bonds[]

EC 3.3.1: Thioether and trialkylsulfonium hydrolases[]

  • EC 3.3.1.1: adenosylhomocysteinase
  • EC 3.3.1.2: S-adenosyl-L-methionine hydrolase (L-homoserine-forming)
  • EC 3.3.1.3: The activity is most probably attributable to EC 4.4.1.21, S-ribosylhomocysteine lyase

EC 3.3.2: Ether Hydrolases[]

  • EC 3.3.2.1: isochorismatase
  • EC 3.3.2.2: alkenylglycerophosphocholine hydrolase
  • EC 3.3.2.3}}: Now known to comprise two enzymes, microsomal epoxide hydrolase (EC 3.3.2.9) and soluble epoxide hydrolase (EC 3.3.2.10)
  • EC 3.3.2.4: trans-epoxysuccinate hydrolase
  • EC 3.3.2.5: Now included in EC 3.3.2.2, lysoplasmalogenase
  • EC 3.3.2.6: [[leukotriene-A4 hydrolase leukotriene-A4 hydrolase]]
  • EC 3.3.2.7: hepoxilin-epoxide hydrolase
  • EC 3.3.2.8: limonene-1,2-epoxide hydrolase
  • EC 3.3.2.9: microsomal epoxide hydrolase
  • EC 3.3.2.10: soluble epoxide hydrolase
  • EC 3.3.2.11: cholesterol-5,6-oxide hydrolase
  • EC 3.3.2.12: oxepin-CoA hydrolase *
  • EC 3.3.2.13: chorismatase *
  • EC 3.3.2.14: 2,4-dinitroanisole O-demethylase *
  • EC 3.3.2.15: trans-2,3-dihydro-3-hydroxyanthranilic acid synthase *
*No Wikipedia article

EC 3.4: Acting on peptide bonds – Peptidase[]

EC 3.4.1 α-amino acyl peptide hydrolases (discontinued)[]

  • EC 3.4.1.1: Now EC 3.4.11.1, leucyl aminopeptidase
  • EC 3.4.1.2: Now EC 3.4.11.2, membrane alanyl aminopeptidase
  • EC 3.4.1.3: Now EC 3.4.11.4, tripeptide aminopeptidase
  • EC 3.4.1.4: Now EC 3.4.11.5, prolyl aminopeptidase

EC 3.4.2 Peptidyl amino acid hydrolases (discontinued)[]

  • EC 3.4.2.1: Now EC 3.4.17.1, carboxypeptidase A
  • EC 3.4.2.2: Now EC 3.4.17.2, carboxypeptidase B
  • EC 3.4.2.3: Now EC 3.4.17.4, Gly-Xaa carboxypeptidase

EC 3.4.3: Dipeptide hydrolases (deleted sub-subclass)[]

  • EC 3.4.3.1: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.3.2: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.3.3: Now EC 3.4.13.3, Xaa-His dipeptidase
  • EC 3.4.3.4: Now EC 3.4.13.5, Xaa-methyl-His dipeptidase
  • EC 3.4.3.5: Now EC 3.4.11.2, membrane alanyl aminopeptidase
  • EC 3.4.3.6: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.3.7: Now EC 3.4.13.9, Xaa-Pro dipeptidase

EC 3.4.4 Peptidyl Peptide Hydrolases (discontinued)[]

  • EC 3.4.4.1: Now EC 3.4.23.1, pepsin A
  • EC 3.4.4.2: Now EC 3.4.23.2, pepsin B
  • EC 3.4.4.3: Now EC 3.4.23.4, chymosin
  • EC 3.4.4.4: Now EC 3.4.21.4, trypsin
  • EC 3.4.4.5: Now EC 3.4.21.1, chymotrypsin
  • EC 3.4.4.6: Now EC 3.4.21.1, chymotrypsin
  • EC 3.4.4.7: Now covered by EC 3.4.21.36, pancreatic elastase and EC 3.4.21.37, leukocyte elastase
  • EC 3.4.4.8: Now EC 3.4.21.9, enteropeptidase
  • EC 3.4.4.9: Now EC 3.4.14.1, dipeptidyl-peptidase I
  • EC 3.4.4.10: Now EC 3.4.22.2, papain
  • EC 3.4.4.11: Now EC 3.4.22.6, chymopapain
  • EC 3.4.4.12: Now EC 3.4.22.3, ficain
  • EC 3.4.4.13: Now EC 3.4.21.5, thrombin
  • EC 3.4.4.14: Now EC 3.4.21.7, plasmin
  • EC 3.4.4.15: Now EC 3.4.23.15, renin
  • EC 3.4.4.16: Now covered by the microbial serine proteinases EC 3.4.21.62 (subtilisin), EC 3.4.21.63 (oryzin), EC 3.4.21.64 (endopeptidase K), EC 3.4.21.65 (thermomycolin), EC 3.4.21.66 (thermitase) and EC 3.4.21.67 (ndopeptidase So)
  • EC 3.4.4.17: Now covered by the microbial aspartic proteinases EC 3.4.23.20 (penicillopepsin), EC 3.4.23.21 (rhizopuspepsin), EC 3.4.23.22 (endothiapepsin), EC 3.4.23.23 (mucorpepsin), EC 3.4.23.24 (candidapepsin), EC 3.4.23.25 (saccharopepsin), EC 3.4.23.26 (rhodotorulapepsin), EC 3.4.21.103 (physarolisin), EC 3.4.23.28 (acrocylindropepsin), EC 3.4.23.29 (polyporopepsin) and EC 3.4.23.30 (pycnoporopepsin)
  • EC 3.4.4.18: Now EC 3.4.22.10, streptopain
  • EC 3.4.4.19: Now EC 3.4.24.3, microbial collagenase
  • EC 3.4.4.20: Now EC 3.4.22.8, clostripain
  • EC 3.4.4.21: Now EC 3.4.21.34 (plasma kallikrein) and EC 3.4.21.35 (tissue kallikrein)
  • EC 3.4.4.22: now EC 3.4.23.3, gastricsin
  • EC 3.4.4.23: now EC 3.4.23.5, cathepsin D
  • EC 3.4.4.24: now covered by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain)
  • EC 3.4.4.25: deleted

EC 3.4.11 Aminopeptidases[]

EC 3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)[]

  • EC 3.4.12.1: now EC 3.4.16.5 (carboxypeptidase C) and EC 3.4.16.6 (carboxypeptidase D)
  • EC 3.4.12.2: now EC 3.4.17.1, carboxypeptidase A
  • EC 3.4.12.3: now EC 3.4.17.2, carboxypeptidase B
  • EC 3.4.12.4: now EC 3.4.16.2, lysosomal Pro-Xaa carboxypeptidase
  • EC 3.4.12.5: now EC 3.5.1.28, N-acetylmuramoyl-L-alanine amidase
  • EC 3.4.12.6: now EC 3.4.17.8, muramoyl-pentapeptidase carboxypeptidase
  • EC 3.4.12.7: now EC 3.4.17.3, lysine carboxypeptidase
  • EC 3.4.12.8: now EC 3.4.17.4, Gly-Xaa carboxypeptidase
  • EC 3.4.12.9: aspartate carboxypeptidase
  • EC 3.4.12.10: now EC 3.4.19.9, γ-glutamyl hydrolase
  • EC 3.4.12.11: now EC 3.4.17.6, alanine carboxypeptidase
  • EC 3.4.12.12: now EC 3.4.16.5 (carboxypeptidase C) and EC 3.4.16.6 (carboxypeptidase D)
  • EC 3.4.12.13: γ-glutamylglutamate carboxypeptidase

EC 3.4.13 Dipeptidases[]

  • EC 3.4.13.1: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.13.2: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.13.3: The activity is covered by EC 3.4.13.18, cytosol nonspecific dipeptidase and EC 3.4.13.20, β-Ala-His dipeptidase.
  • EC 3.4.13.4: Xaa-Arg dipeptidase
  • EC 3.4.13.5: Xaa-methyl-His dipeptidase
  • EC 3.4.13.6: Now EC 3.4.11.2, membrane alanyl aminopeptidase
  • EC 3.4.13.7: Glu-Glu dipeptidase
  • EC 3.4.13.8: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.13.9: Xaa-Pro dipeptidase
  • EC 3.4.13.10: Now EC 3.4.19.5, β-aspartyl-peptidase
  • EC 3.4.13.11: T Now EC 3.4.13.19, membrane dipeptidase
  • EC 3.4.13.12: Met-Xaa dipeptidase
  • EC 3.4.13.13: Now EC 3.4.13.3, Xaa-His dipeptidase
  • EC 3.4.13.14: Deleted
  • EC 3.4.13.15: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.13.16: Deleted
  • EC 3.4.13.17: non-stereospecific dipeptidase
  • EC 3.4.13.18: cytosol nonspecific dipeptidase
  • EC 3.4.13.19: membrane dipeptidase
  • EC 3.4.13.20: β-Ala-His dipeptidase
  • EC 3.4.13.21: dipeptidase E
  • EC 3.4.13.22: D-Ala-D-Ala dipeptidase
  • EC 3.4.13.23: cysteinylglycine-S-conjugate dipeptidase *
*No Wikipedia article

EC 3.4.14 Dipeptidyl peptidases and tripeptidyl peptidases[]

  • EC 3.4.14.1: dipeptidyl-peptidase I
  • EC 3.4.14.2: dipeptidyl-peptidase II
  • EC 3.4.14.3: Now EC 3.4.19.1, acylaminoacyl-peptidase
  • EC 3.4.14.4: dipeptidyl-peptidase III
  • EC 3.4.14.5: dipeptidyl-peptidase IV
  • EC 3.4.14.6: dipeptidyl-dipeptidase
  • EC 3.4.14.7: Deleted
  • EC 3.4.14.8: Now EC 3.4.14.10, tripeptidyl-peptidase II
  • EC 3.4.14.9: tripeptidyl-peptidase I
  • EC 3.4.14.10: tripeptidyl-peptidase II
  • EC 3.4.14.11: Xaa-Pro dipeptidyl-peptidase
  • EC 3.4.14.12: Xaa-Xaa-Pro tripeptidyl-peptidase
  • EC 3.4.14.13: γ-D-glutamyl-Llysine dipeptidyl-peptidase *
  • EC 3.4.14.14: [mycofactocin precursor peptide] peptidase *
*No Wikipedia article

EC 3.4.15 Peptidyl dipeptidases[]

  • EC 3.4.15.1: peptidyl-dipeptidase A
  • EC 3.4.15.2: Now EC 3.4.19.2, peptidyl-glycinamidase
  • EC |3.4.15.3: Now EC 3.4.15.5, peptidyl-dipeptidase Dcp
  • EC 3.4.15.4: Peptidyl-dipeptidase B
  • EC 3.4.15.5: Peptidyl-dipeptidase Dcp
  • EC 3.4.15.6: cyanophycinase

EC 3.4.16 Serine type carboxypeptidases[]

  • EC 3.4.16.1: Transferred entry: serine carboxypeptidase. Now EC 3.4.16.6, carboxypeptidase D
  • EC 3.4.16.2: lysosomal Pro-Xaa carboxypeptidase
  • EC 3.4.16.3: Now included with EC 3.4.16.5, carboxypeptidase C
  • EC 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase
  • EC 3.4.16.5: carboxypeptidase C
  • EC 3.4.16.6: carboxypeptidase D

EC 3.4.17 Metallocarboxypeptidases[]

*No Wikipedia article

EC 3.4.18 Cysteine type carboxypeptidases[]

EC 3.4.19 Omega peptidases[]

*No Wikipedia article

EC 3.4.21: Serine proteases[]

*No Wikipedia article

EC 3.4.22 Cysteine proteases[]

EC 3.4.23 Aspartic endopeptidases[]

EC 3.4.24: Metallopeptidases[]

EC 3.4.25 Threonine endopeptidases[]

EC 3.4.99 []

  • EC 3.4.99.1: acrocylindricum proteinase. Now EC 3.4.23.28, acrocylindropepsin
  • EC 3.4.99.2: Deleted entry: agavain
  • EC 3.4.99.3: Deleted entry: angiotensinase
  • EC 3.4.99.4: Transferred entry: aspartylendopeptidase. Now EC 3.4.23.12, nepenthesin
  • EC 3.4.99.5: Transferred entry: Clostridium histolyticum collagenase 2. Now EC 3.4.24.3, microbial collagenase
  • EC 3.4.99.6: Transferred entry: crayfish low-molecular-weight proteinase. Now EC 3.4.24.21, astacin
  • EC 3.4.99.7: Deleted entry: euphorbain
  • EC 3.4.99.8: Deleted entry: Gliocladium proteinase
  • EC 3.4.99.9: Deleted entry: hurain. Now considered EC 3.4.21.25, cucumisin
  • EC 3.4.99.10: Transferred entry: insulinase. Now EC 3.4.24.56, insulysin
  • EC 3.4.99.11: Deleted entry: Streptomyces alkalophilic keratinase
  • EC 3.4.99.12: Deleted entry: Trichophyton mentagrophytes keratinase
  • EC 3.4.99.13: Transferred entry: β-lytic proteinase (Mycobacterium sorangium). Now EC 3.4.24.32, β-lytic metalloendopeptidase
  • EC 3.4.99.14: Deleted entry: mexicanain
  • EC 3.4.99.15: Deleted entry: Paecilomyces proteinase
  • EC 3.4.99.16: Deleted entry: Penicillium notatum extracellular proteinase
  • EC 3.4.99.17: Deleted entry: peptidoglycan endopeptidase
  • EC 3.4.99.18: Deleted entry: pinguinain
  • EC 3.4.99.19: Transferred entry: renin. Now EC 3.4.23.15, renin
  • EC 3.4.99.20: Deleted entry: scopulariopsis proteinase
  • EC 3.4.99.21: Deleted entry: solanain. Now considered EC 3.4.21.25, cucumisin
  • EC 3.4.99.22: Transferred entry: staphylokinase. Now EC 3.4.24.29, aureolysin
  • EC 3.4.99.23: Deleted entry: tabernamontanain. Now considered EC 3.4.21.25, cucumisin
  • EC 3.4.99.24: Deleted entry: Tenebrio α-proteinase
  • EC 3.4.99.25: Transferred entry: trametes acid proteinase. Now EC 3.4.23.21, rhizopuspepsin
  • EC 3.4.99.26: Transferred entry: urokinase. Now EC 3.4.21.68, t-plasminogen activator
  • EC 3.4.99.27: Deleted entry: Echis carinatus prothrombin-activating proteinase
  • EC 3.4.99.28: Transferred entry: Oxyuranus scutellatus prothrombin-activating proteinase. Now EC 3.4.21.60, scutelarin
  • EC 3.4.99.29: Deleted entry: Myxobacter AL-1 proteinase I
  • EC 3.4.99.30: Transferred entry: Myxobacter AL-1 proteinase II. Now EC 3.4.24.20, peptidyl-Lys metalloendopeptidase
  • EC 3.4.99.31: Transferred entry: tissue endopeptidase degrading collagenase synthetic substrate. Now EC 3.4.24.15, thimet oligopeptidase
  • EC 3.4.99.32: Transferred entry: Armillaria mellea neutral proteinase. Now EC 3.4.24.20, peptidyl-Lys metalloendopeptidase
  • EC 3.4.99.33: Deleted entry: cathepsin R
  • EC 3.4.99.34: Deleted entry: mytilidase
  • EC 3.4.99.35: Transferred entry: premurein-leader peptidase. Now EC 3.4.23.36, signal peptidase II
  • EC 3.4.99.36: Transferred entry: leader peptidase. Now EC 3.4.21.89, signal peptidase I
  • EC 3.4.99.37: Deleted entry: RecA peptidase
  • EC 3.4.99.38: Transferred entry: pro-opiomelanotropin-converting proteinase. Now EC 3.4.23.17, pro-opiomelanocortin converting enzyme
  • EC 3.4.99.39: Deleted entry: pseudomurein endopeptidase
  • EC 3.4.99.40: Deleted entry: pro-gonadoliberin proteinase
  • EC 3.4.99.41: Transferred entry: mitochondrial processing peptidase. Now EC 3.4.24.64, mitochondrial processing peptidase
  • EC 3.4.99.42: Deleted entry: leucyllysine endopeptidase
  • EC 3.4.99.43: Transferred entry: thermopsin. Now EC 3.4.23.42, thermopsin
  • EC 3.4.99.44: Transferred entry: pitrilysin. Now EC 3.4.24.55, pitrilysin
  • EC 3.4.99.45: Transferred entry: insulinase. Now EC 3.4.24.56, insulysin
  • EC 3.4.99.46: Transferred entry: multicatalytic endopeptidase complex. Now EC 3.4.25.1, proteasome endopeptidase complex

EC 3.5: Acting on carbon-nitrogen bonds, other than peptide bonds[]

3.5.1: In linear amides[]

*No Wikipedia article

3.5.2: In cyclic amides[]

*No Wikipedia article

3.5.3: In linear amidines[]

*No Wikipedia article

3.5.4: In cyclic amidines[]

  • EC 3.5.4.1: cytosine deaminase
  • EC 3.5.4.2: adenine deaminase
  • EC 3.5.4.3: guanine deaminase
  • EC 3.5.4.4: adenosine deaminase
  • EC 3.5.4.5: cytidine deaminase
  • EC 3.5.4.6: AMP deaminase
  • EC 3.5.4.7: ADP deaminase
  • EC 3.5.4.8: aminoimidazolase
  • EC 3.5.4.9: methenyltetrahydrofolate cyclohydrolase
  • EC 3.5.4.10: IMP cyclohydrolase
  • EC 3.5.4.11: pterin deaminase
  • EC 3.5.4.12: dCMP deaminase
  • EC 3.5.4.13: dCTP deaminase
  • EC 3.5.4.14: Now included in EC 3.5.4.5, (deoxy)cytidine deaminase
  • EC 3.5.4.15: guanosine deaminase
  • EC 3.5.4.16: GTP cyclohydrolase I
  • EC 3.5.4.17: adenosine-phosphate deaminase
  • EC 3.5.4.18: ATP deaminase
  • EC 3.5.4.19: phosphoribosyl-AMP cyclohydrolase
  • EC 3.5.4.20: pyrithiamine deaminase
  • EC 3.5.4.21: creatinine deaminase
  • EC 3.5.4.22: 1-pyrroline-4-hydroxy-2-carboxylate deaminase
  • EC 3.5.4.23: blasticidin-S deaminase
  • EC 3.5.4.24: sepiapterin deaminase
  • EC 3.5.4.25: GTP cyclohydrolase II
  • EC 3.5.4.26: diaminohydroxyphosphoribosylaminopyrimidine deaminase
  • EC 3.5.4.27: methenyltetrahydromethanopterin cyclohydrolase
  • EC 3.5.4.28: S-adenosylhomocysteine deaminase
  • EC 3.5.4.29: GTP cyclohydrolase IIa
  • EC 3.5.4.30: dCTP deaminase (dUMP-forming)
  • EC 3.5.4.31: S-methyl-5′-thioadenosine deaminase
  • EC 3.5.4.32: 8-oxoguanine deaminase
  • EC 3.5.4.33: tRNA(adenine34) deaminase *
  • EC 3.5.4.34: tRNAAla(adenine37) deaminase *
  • EC 3.5.4.35: tRNA(cytosine8) deaminase *
  • EC 3.5.4.36: mRNA(cytosine6666) deaminase *
  • EC 3.5.4.37: double-stranded RNA adenine deaminase *
  • EC 3.5.4.38: single-stranded DNA cytosine deaminase *
  • EC 3.5.4.39: GTP cyclohydrolase IV *
  • EC 3.5.4.40: aminodeoxyfutalosine deaminase *
  • EC 3.5.4.41: 5′-deoxyadenosine deaminase *
  • EC 3.5.4.42: N-isopropylammelide isopropylaminohydrolase *
  • EC 3.5.4.43: hydroxydechloroatrazine ethylaminohydrolase *
  • EC 3.5.4.44: ectoine hydrolase *
  • EC 3.5.4.45: melamine deaminase *
  • EC 3.5.4.46: cAMP deaminase *
*No Wikipedia article

3.5.5: In nitriles[]

  • EC 3.5.5.1: nitrilase
  • EC 3.5.5.2: ricinine nitrilase
  • EC 3.5.5.3: C 4.2.1.104, cyanate hydratase
  • EC 3.5.5.4: cyanoalanine nitrilase
  • EC 3.5.5.5: arylacetonitrilase
  • EC 3.5.5.6: bromoxynil nitrilase
  • EC 3.5.5.7: aliphatic nitrilase
  • EC 3.5.5.8: thiocyanate hydrolase

3.5.99: In other compounds[]

*No Wikipedia article

EC 3.6: Acting on acid anhydrides[]

3.6.1: In phosphorus-containing anhydrides[]

*No Wikipedia article

3.6.2: In sulfonyl-containing anhydrides[]

3.6.3: Acting on acid anhydrides to catalyse transmembrane movement of substances[]

  • EC 3.6.3.1: phospholipid-translocating ATPase
  • EC 3.6.3.2: Now EC 7.2.2.14, P-type Mg2+ transporter
  • EC 3.6.3.3: Now EC 7.2.2.21, Cd2+-exporting ATPase
  • EC 3.6.3.4: Now EC 7.2.2.9, Cu2+-exporting ATPase
  • EC 3.6.3.5: Now EC 7.2.2.12, Zn2+-exporting ATPase
  • EC 3.6.3.6: Now EC 7.1.2.1, P-type H+-exporting transporter
  • EC 3.6.3.7: Now EC 7.2.2.3, P-type Na+ transporter
  • EC 3.6.3.8: Now EC 7.2.2.10, Ca2+-transporting ATPase
  • EC 3.6.3.9: Now EC 7.2.2.13, Na+/K+-exchanging ATPase
  • EC 3.6.3.10: Now EC 7.2.2.19, H+/K+-exchanging ATPase
  • EC 3.6.3.11: Cl–-transporting ATPase. The activity was only ever studied in crude extracts, and is an artifact
  • EC 3.6.3.12: Now EC 7.2.2.6, K+-transporting ATPase
  • EC 3.6.3.13:Identical to EC 3.6.3.1, phospholipid-translocating ATPase
  • EC 3.6.3.14: Now EC 7.1.2.2, H+-transporting two-sector ATPase
  • EC 3.6.3.15: Now EC 7.2.2.1, Na+-transporting two-sector ATPase
  • EC 3.6.3.16: Now EC 7.3.2.7, arsenite-transporting ATPase
  • EC 3.6.3.17: Now covered by various ABC-type monosaccharide transporters in sub-subclass EC 7.5.2
  • EC 3.6.3.18: Now EC 7.5.2.2, ABC-type oligosaccharide transporter
  • EC 3.6.3.19: Now EC 7.5.2.1, ABC-type maltose transporter
  • EC 3.6.3.20: Now EC 7.6.2.10, glycerol-3-phosphate-transporting ATPase
  • EC 3.6.3.21: Now EC 7.4.2.1, ABC-type polar-amino-acid transporter
  • EC 3.6.3.22: Now EC 7.4.2.2, ABC-type nonpolar-amino-acid transporter
  • EC 3.6.3.23: Now EC 7.4.2.6, oligopeptide-transporting ATPase
  • EC 3.6.3.24: Now EC 7.2.2.11, nickel-transporting ATPase
  • EC 3.6.3.25: Now EC 7.3.2.3, sulfate-transporting ATPase
  • EC 3.6.3.26: Now EC 7.3.2.4, nitrate-transporting ATPase
  • EC 3.6.3.27: Now EC 7.3.2.1, ABC-type phosphate transporter
  • EC 3.6.3.28: Now EC 7.3.2.2, ABC-type phosphonate transporter
  • EC 3.6.3.29: Now EC 7.3.2.5, molybdate-transporting ATPase
  • EC 3.6.3.30: Now EC 7.2.2.7, Fe3+-transporting ATPase
  • EC 3.6.3.31: Now EC 7.6.2.11, polyamine-transporting ATPase
  • EC 3.6.3.32: Now EC 7.6.2.9, quaternary-amine-transporting ATPase
  • EC 3.6.3.33: Now EC 7.6.2.8, vitamin B12-transporting ATPase
  • EC 3.6.3.34: now recognized to be at least three separate enzymes EC 7.2.2.16, iron(III) hydroxamate ABC transporter, EC 7.2.2.17, ferric enterobactin ABC transporter, and EC 7.2.2.18, ferric citrate ABC transporter
  • EC 3.6.3.35: Now EC 7.2.2.5, manganese-transporting ATPase
  • EC 3.6.3.36: Now EC 7.6.2.7, taurine-transporting ATPase
  • EC 3.6.3.37: Now EC 7.6.2.6, guanine-transporting ATPase
  • EC 3.6.3.38: Now EC 7.6.2.12, ABC-type capsular-polysaccharide transporter
  • EC 3.6.3.39: Now EC 7.5.2.5, lipopolysaccharide-transporting ATPase
  • EC 3.6.3.40: Now EC 7.5.2.4, teichoic-acid-transporting ATPase
  • EC 3.6.3.41: Now EC 7.6.2.5, heme-transporting ATPase
  • EC 3.6.3.42: Now EC 7.5.2.3, β-glucan-transporting ATPase
  • EC 3.6.3.43: Now EC 7.4.2.5, peptide-transporting ATPase
  • EC 3.6.3.44: Now EC 7.6.2.2, ABC-type xenobiotic transporter
  • EC 3.6.3.45: Now included with EC 3.6.3.44, xenobiotic-transporting ATPase
  • EC 3.6.3.46: Now EC 7.2.2.2, ABC-type Cd2+ transporter
  • EC 3.6.3.47: Now EC 7.6.2.4, fatty-acyl-CoA-transporting ATPase
  • EC 3.6.3.48: Now EC 7.4.2.7 as α-factor-pheromone transporting ATPase
  • EC 3.6.3.49: Now EC 5.6.1.6, channel-conductance-controlling ATPase
  • EC 3.6.3.50: Now EC 7.4.2.8, protein-secreting ATPase
  • EC 3.6.3.51: Now EC 7.4.2.3, mitochondrial protein-transporting ATPase
  • EC 3.6.3.52: Now EC 7.4.2.4, chloroplast protein-transporting ATPase
  • EC 3.6.3.53: Now EC 7.2.2.15, Ag+-exporting ATPase
  • EC 3.6.3.54: Now EC 7.2.2.8, Cu+-exporting ATPase
  • EC 3.6.3.55: Now EC 7.3.2.6, tungstate-importing ATPase

3.6.4: Acting on acid anhydrides to facilitate cellular and subcellular movement[]

  • EC 3.6.4.1: Now EC 5.6.1.8, myosin ATPase
  • EC 3.6.4.2: Now EC 5.6.1.2, dynein ATPase
  • EC 3.6.4.3: Now EC 5.6.1.1, microtubule-severing ATPase
  • EC 3.6.4.4: Now EC 5.6.1.3, plus-end-directed kinesin ATPase
  • EC 3.6.4.5: Now EC 5.6.1.4, minus-end-directed kinesin ATPase
  • EC 3.6.4.6: vesicle-fusing ATPase
  • EC 3.6.4.7: peroxisome-assembly ATPase
  • EC 3.6.4.8: Now EC 5.6.1.5, proteasome ATPase
  • EC 3.6.4.9: Now EC 5.6.1.7, chaperonin ATPase
  • EC 3.6.4.10: non-chaperonin molecular chaperone ATPase
  • EC 3.6.4.11: Deleted, the activity has been shown not to take place
  • EC 3.6.4.12: DNA helicase
  • EC 3.6.4.13: RNA helicase

3.6.5: Acting on GTP to facilitate cellular and subcellular movement[]

  • EC 3.6.5.1: heterotrimeric G-protein GTPase
  • EC 3.6.5.2: small monomeric GTPase
  • EC 3.6.5.3: protein-synthesizing GTPase
  • EC 3.6.5.4: signal-recognition-particle GTPase
  • EC 3.6.5.5: dynamin GTPase
  • EC 3.6.5.6: tubulin GTPase

EC 3.7: Acting on carbon-carbon bonds[]

EC 3.7.1: In ketonic substances[]

  • EC 3.7.1.1: oxaloacetase
  • EC 3.7.1.2: fumarylacetoacetase
  • EC 3.7.1.3: kynureninase
  • EC 3.7.1.4: phloretin hydrolase
  • EC 3.7.1.5: acylpyruvate hydrolase
  • EC 3.7.1.6: acetylpyruvate hydrolase
  • EC 3.7.1.7: β-diketone hydrolase
  • EC 3.7.1.8: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
  • EC 3.7.1.9: 2-hydroxymuconate-semialdehyde hydrolase
  • EC 3.7.1.10: cyclohexane-1,3-dione hydrolase
  • EC 3.7.1.11: cyclohexane-1,2-dione hydrolase
  • EC 3.7.1.12: cobalt-precorrin 5A hydrolase
  • EC 3.7.1.13: 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase
  • EC 3.7.1.14: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
  • EC 3.7.1.15: Now EC 4.2.1.138, (+)-caryolan-1-ol synthase
  • EC 3.7.1.16: Now EC 3.3.2.12, oxepin-CoA hydrolase
  • EC 3.7.1.17: 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
  • EC 3.7.1.18: 6-oxocamphor hydrolase
  • EC 3.7.1.19: 2,6-dihydroxypseudooxynicotine hydrolase
  • EC 3.7.1.20: 3-fumarylpyruvate hydrolase
  • EC 3.7.1.21: 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase *
  • EC 3.7.1.22: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (ring-opening)
  • EC 3.7.1.23: maleylpyruvate hydrolase *
  • EC 3.7.1.24: 2,4-diacetylphloroglucinol hydrolase *
  • EC 3.7.1.25: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase *
  • EC 3.7.1.26: 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase *
  • EC 3.7.1.27: neryl diphosphate diphosphatase *
  • EC 3.7.1.28: 3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase *
*No Wikipedia article

EC 3.8: Acting on halide bonds[]

EC 3.8.1: Acting on halide bonds[]

  • EC 3.8.1.1: Covered by EC 3.8.1.5, haloalkane dehalogenase.
  • EC 3.8.1.2: (S)-2-haloacid dehalogenase
  • EC 3.8.1.3: haloacetate dehalogenase
  • EC 3.8.1.4: Now EC 1.97.1.10, thyroxine 5′-deiodinase
  • EC 3.8.1.5: haloalkane dehalogenase
  • EC 3.8.1.6: 4-chlorobenzoate dehalogenase
  • EC 3.8.1.7: 4-chlorobenzoyl-CoA dehalogenase
  • EC 3.8.1.8: atrazine chlorohydrolase
  • EC 3.8.1.9: (R)-2-haloacid dehalogenase
  • EC 3.8.1.10: 2-haloacid dehalogenase (configuration-inverting)
  • EC 3.8.1.11: 2-haloacid dehalogenase (configuration-retaining)

3.8.2: In phosphorus-halide compounds (deleted sub-subclass)[]

  • EC 3.8.2.1: Now EC 3.1.8.2, diisopropyl-fluorophosphatase

EC 3.9: act on phosphorus-nitrogen bonds[]

EC 3.9.1: Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)[]

  • EC 3.9.1.1: phosphoamidase
  • EC 3.9.1.2: protein arginine phosphatase *
  • EC 3.9.1.3: phosphohistidine phosphatase *
*No Wikipedia article

EC 3.10: Acting on sulfur-nitrogen bonds[]

EC 3.10.1: Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)[]

EC 3.11: Acting on carbon-phosphorus bonds[]

EC 3.11.1: Acting on carbon-phosphorus bonds (only sub-subclass identified to date)[]

  • EC 3.11.1.1: phosphonoacetaldehyde hydrolase
  • EC 3.11.1.2: phosphonoacetate hydrolase
  • EC 3.11.1.3: phosphonopyruvate hydrolase

EC 3.12: Acting on sulfur-sulfur bonds[]

EC 3.12.1: Acting on sulfur-sulfur bonds (only sub-subclass identified to date)[]

EC 3.13: Acting on carbon-sulfur bonds[]

EC 3.13.1: Acting on carbon-sulfur bonds (only sub-subclass identified to date)[]

  • EC 3.13.1.1: UDP-sulfoquinovose synthase
  • EC 3.13.1.2: Deleted, the activity is most probably attributable to EC 4.4.1.21, S-ribosylhomocysteine lyase
  • EC 3.13.1.3: 2′-hydroxybiphenyl-2-sulfinate desulfinase
  • EC 3.13.1.4: 3-sulfinopropanoyl-CoA desulfinase *
  • EC 3.13.1.5: carbon disulfide hydrolase
  • EC 3.13.1.6: [CysO sulfur-carrier protein]-S-L-cysteine hydrolase *
  • EC 3.13.1.7: Carbonyl sulfide hydrolase
  • EC 3.13.1.8: S-adenosyl-L-methionine hydrolase (adenosine-forming *
  • EC 3.13.1.9: S-inosyl-L-homocysteine hydrolase *
*No Wikipedia article

References[]

  1. ^ "ExplorEnz – The Enzyme Database".
  2. ^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37: D593–D597. doi:10.1093/nar/gkn582.
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