List of enzymes
This article needs to be updated. The reason given is: Is missing the recent classification changes resulting from the creation of EC 7.(February 2019) |
This article lists enzymes by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission [EC] numbering system.
Category:Oxidoreductases (EC 1) (Oxidoreductase)[]
- Dehydrogenase
- Luciferase
- DMSO reductase
Category:EC 1.1 (act on the CH-OH group of donors)[]
- Category:EC 1.1.1 (with NAD+ or NADP+ as acceptor)
- Alcohol dehydrogenase (NAD) EC 1.1.1.1
- Alcohol dehydrogenase (NADP) EC 1.1.1.2
- Homoserine dehydrogenase EC 1.1.1.3
- Aminopropanol oxidoreductase EC 1.1.1.4
- Diacetyl reductase EC 1.1.1.5
- Glycerol dehydrogenase EC 1.1.1.6
- Propanediol-phosphate dehydrogenase EC 1.1.1.7
- glycerol-3-phosphate dehydrogenase (NAD+) EC 1.1.1.8
- D-xylulose reductase EC 1.1.1.9
- L-xylulose reductase EC 1.1.1.10
- Lactate dehydrogenase EC 1.1.1.27
- Malate dehydrogenase EC 1.1.1.37
- Isocitrate dehydrogenase EC 1.1.1.42
- HMG-CoA reductase EC 1.1.1.88
- Category:EC 1.1.2 (with a cytochrome as acceptor)
- Category:EC 1.1.3 (with oxygen as acceptor)
- Glucose oxidase EC 1.1.3.4
- L-gulonolactone oxidase EC 1.1.3.8
- Thiamine oxidase EC 1.1.3.23
- Xanthine oxidase EC 1.1.3.32
- (with a disulfide as acceptor)
- Category:EC 1.1.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.1.99 (with other acceptors)
Category:EC 1.2 (act on the aldehyde or oxo group of donors)[]
- Category:EC 1.2.1 (with NAD+ or NADP+ as acceptor)
- Acetaldehyde dehydrogenase EC 1.2.1.10
- Glyceraldehyde 3-phosphate dehydrogenase EC 1.2.1.12
- Pyruvate dehydrogenase EC 1.2.1.51
- Category:EC 1.2.4
Category:EC 1.3 (act on the CH-CH group of donors)[]
- Category:EC 1.3.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.3.2 (with a cytochrome as acceptor)
- Category:EC 1.3.3 (with oxygen as acceptor)
- Category:EC 1.3.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.3.7 (with an iron-sulfur protein as acceptor)
- Category:EC 1.3.99 (with other acceptors)
Category:EC 1.4 (act on the CH-NH2 group of donors)[]
Category:EC 1.5 (act on CH-NH group of donors)[]
- Category:EC 1.5.1 (with NAD+ or NADP+ as acceptor)
- Dihydrofolate reductase EC 1.5.1.3
- Methylenetetrahydrofolate reductase EC 1.5.1.20
- Category:EC 1.5.3 (with oxygen as acceptor)
- Category:EC 1.5.4 (with a disulfide as acceptor)
- Category:EC 1.5.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.5.7 (with an iron-sulfur protein as acceptor)
- Category:EC 1.5.8 (with a flavin as acceptor)
- Category:EC 1.5.99 (with other acceptors)
Category:EC 1.6 (act on NADH or NADPH)[]
- Category:EC 1.6.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.6.2 (with a cytochrome as acceptor)
- Category:EC 1.6.3 (with oxygen as acceptor)
- Category:EC 1.6.4 now Category:EC 1.8.1
- Category:EC 1.6.5 (with a quinone or similar compound as acceptor)
- (with a nitrogenous group as acceptor)
- Category:EC 1.6.7 now Category:EC 1.18.1
- Category:EC 1.6.8 now Category:EC 1.5.1
- Category:EC 1.6.99 (with other acceptors)
Category:EC 1.7 (act on other nitrogenous compounds as donors)[]
- Category:EC 1.7.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.7.2 (with a cytochrome as acceptor)
- Category:EC 1.7.3 (with oxygen as acceptor)
- Category:EC 1.7.7 (with an iron-sulfur protein as acceptor)
- Category:EC 1.7.99 (with other acceptors)
- Nitrite reductase EC 1.7.99.3
- Nitrate reductase EC 1.7.99.4
Category:EC 1.8 (act on a sulfur group of donors)[]
- Category:EC 1.8.1 (with NAD+ or NADP+ as acceptor)
- Glutathione reductase EC 1.8.1.7
- Thioredoxin reductase EC 1.8.1.9
- Category:EC 1.8.2 (with a cytochrome as acceptor)
- Category:EC 1.8.3 (with oxygen as acceptor)
- Category:EC 1.8.4 (with a disulfide as acceptor)
- Category:EC 1.8.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.8.6 deleted, included in EC 2.5.1.18
- Category:EC 1.8.7 (with an iron-sulfur protein as acceptor)
- Category:EC 1.8.98 (with other, known, acceptors)
- Category:EC 1.8.99 (with other acceptors)
Category:EC 1.9 (act on a heme group of donors)[]
- Category:EC 1.9.3 (with oxygen as acceptor)
- Category:EC 1.9.6 (with a nitrogenous as acceptor)
- Category:EC 1.9.99 transferred, now EC 1.9.98.1
[]
- Category:EC 1.10.1(with NAD+ or NADP+ as acceptor)
- (with a cytochrome as acceptor)
- Category:EC 1.10.3 (with oxygen as acceptor)
- Catechol oxidase EC 1.10.3.1
- Laccase EC 1.10.3.2
- Category:EC 1.10.99 (with other acceptors)
Category:EC 1.11 (act on peroxide as an acceptor -- peroxidases)[]
- Category:EC 1.11.1 (peroxidases)
Category:EC 1.12 (act on hydrogen as a donor)[]
- Category:EC 1.12.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.12.2 (with a cytochrome as acceptor)
- Category:EC 1.12.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.12.7 (with an iron-sulfur protein as acceptor)
- Category:EC 1.12.98 (with other known acceptors)
- Category:EC 1.12.99 (with other acceptors)
Category:EC 1.13 (act on single donors with incorporation of molecular oxygen)[]
- Category:EC 1.13.11 (With incorporation of two atoms of oxygen)
- 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)
- Category:EC 1.13.12 (With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases))
Category:EC 1.14 (act on paired donors with incorporation of molecular oxygen)[]
- Cytochrome P450 oxidase
- Category:Cytochrome P450
- Category:EC 1.14.12
- Category:EC 1.14.13
- Nitric oxide synthase EC 1.14.13.39
- Category:EC 1.14.14
- Category:EC 1.14.16
- Category:EC 1.14.18
Category:EC 1.15 (act on superoxide radicals as acceptors)[]
Category:EC 1.16 (oxidize metal ions)[]
- Category:EC 1.16.3
Category:EC 1.17 (act on CH or CH2 groups)[]
- Category:EC 1.17.1
- Category:EC 1.17.2
- Category:EC 1.17.3
- Category:EC 1.17.4
- Category:EC 1.17.5
- Category:EC 1.17.7
- Category:EC 1.17.99
Category:EC 1.18 (act on iron-sulfur proteins as donors)[]
Category:EC 1.19 (act on reduced flavodoxin as donor)[]
- Category:EC 1.19.6
Category:EC 1.20 (act on phosphorus or arsenic as donors)[]
- Category:EC 1.20.1
- Category:EC 1.20.2
- Category:EC 1.20.4
- Arsenate reductase (glutaredoxin) EC 1.20.4.1
- Glutaredoxin
- Category:EC 1.20.9
- Category:EC 1.20.99
Category:EC 1.21 (act on X-H and Y-H to form an X-Y bond)[]
- Category:EC 1.21.1
- Category:EC 1.21.3
- Category:EC 1.21.4
- Category:EC 1.21.99
Category:EC 1.97 (other oxidoreductases)[]
Category:Transferases (EC 2) (Transferase)[]
Category:EC 2.1 (transfer one-carbon groups, Methylase)[]
- Category:EC 2.1.1
- Category:EC 2.1.3
Category:EC 2.2 (transfer aldehyde or ketone groups)[]
- Category:EC 2.2.1
Category:EC 2.3 (acyltransferases)[]
- Category:EC 2.3.1
- Aminolevulinic acid synthase EC 2.3.1.37
- Choline acetyltransferase EC 2.3.1.6
- Category:EC 2.3.2
Category:EC 2.4 (glycosyltransferases)[]
- Category:EC 2.4.2
Category:EC 2.5
- Category:EC 2.5.1
Category:EC 2.5 (transfer alkyl or aryl groups, other than methyl groups)[]
Category:EC 2.6 (transfer nitrogenous groups)[]
Category:EC 2.7 (transfer phosphorus-containing groups)[]
- Category:EC 2.7.2
Category:EC 2.8 (transfer sulfur-containing groups)[]
- EC 2.8.1.1: Thiosulfate sulfurtransferase
- EC 2.8.1.2: 3-mercaptopyruvate sulfurtransferase
- EC 2.8.1.3: Thiosulfate--thiol sulfurtransferase
- EC 2.8.1.4:
- EC 2.8.1.5: Thiosulfate--dithiol sulfurtransferase
- EC 2.8.1.6: Biotin synthase
- EC 2.8.1.7: Cysteine desulfurase
- EC 2.8.1.8: Lipoyl synthase
- EC 2.8.1.9: Molybdenum cofactor sulfurtransferase
- EC 2.8.1.10: Thiazole synthase
- EC 2.8.1.11: Molybdopterin synthase sulfurtransferase
- EC 2.8.1.12: Molybdopterin synthase
- EC 2.8.1.13:
- EC 2.8.1.14:
- EC 2.8.1.15:
Category:EC 2.9 (transfer selenium-containing groups)[]
Category:Hydrolases (EC 3) (Hydrolase)[]
- Hydrolytic enzyme
Category:EC 3.1 (act on ester bonds)[]
- Nuclease
- Endonuclease
- Exonuclease
- Category:EC 3.1.1
- Acid hydrolase
- Phospholipase A (EC 3.1.1.4)
- Acetylcholinesterase (EC 3.1.1.7)
- Cholinesterase (EC 3.1.1.8)
- Lipoprotein lipase (EC 3.1.1.34)
- Category:EC 3.1.2
- Category:EC 3.1.3
- Phosphatase
- Alkaline phosphatase (EC 3.1.3.1)
- Fructose bisphosphatase (EC 3.1.3.11)
- Category:EC 3.1.4
- Phospholipase C (EC 3.1.4.3)
- CGMP specific phosphodiesterase type 5 (EC 3.1.4.17)
- Phospholipase D (EC 3.1.4.50)
- Category:EC 3.1.21
- Category:EC 3.1.26
- Category:EC 3.1.27
- Ribonuclease
Category:EC 3.2 (act on sugars - glycosylases)[]
- Category:EC 3.2.1
Function and clinical importance of some enzymes in category 3.2.1[]
Amylase[]
Function: Amylase is an enzyme that is responsible for the breaking of the bonds in starches, polysaccharides, and complex carbohydrates to be turned into simple sugars that will be easier to absorb.
Clinical Significance: Amylase also has medical history in the use of Pancreatic Enzyme Replacement Therapy (PERT). One of the components is Sollpura (liprotamase), which help in the breakdown of saccharides into simple sugars.
Lysozyme[]
Function: An enzyme that is produced by animals that forms part of the innate immune system and is abundant in the secretions of saliva, human milk, tears, and mucus. It functions as an antimicrobial agent by splitting the peptidoglycan component of bacterial cell walls, which then leads to cell death.
Clinical Significance: Toxic levels of blood are caused by the excessive production of lysozyme's by cancer cells. Lysozyme's have also been associated with Bronchopulmonary dysplasia (BPD) in newborns and is a key factor in providing the immunology of infants during breast feeding.
Sucrase[]
Function: Sucrase is a stomachs related protein that mobilizes hydrolysis to convert sucrose into glucose and fructose.
Clinical Significance: Low amounts of Sucrose also known as Sucrose intolerance happens when sucrose isn’t being discharged in the small digestive tract. A result of this is extra gas.
Lactase[]
Function: lactase is located in the small digestives system of people and other creatures such as mammals. Lactase is the bases of the total absorption of milk.
Clinical Significance: People who are lactose intolerant have medicine that can help with the digestion. When you are lactose intolerant you might experience gas, bloating, and pain along with other symptoms regarding your digestive system.
Category:EC 3.3 (act on ether bonds)[]
- Category:EC 3.3
- Adenosylmethionine hydrolase
- S-adenosyl-L-homocysteine hydrolase
- Alkenylglycerophosphocholine hydrolase
- Alkenylglycerophosphoethanolamine hydrolase
- Cholesterol-5,6-oxide hydrolase
- Hepoxilin-epoxide hydrolase
- Isochorismatase
- Leukotriene-A4 hydrolase
- Limonene-1,2-epoxide hydrolase
- Microsomal epoxide hydrolase
- Trans-epoxysuccinate hydrolase
Category:EC 3.4 (act on peptide bonds - Peptidase)[]
- Category:EC 3.4.11
- Category:EC 3.4.15
- Angiotensin converting enzyme
- Category:EC 3.4.21
- Serine protease
- Chymotrypsin (EC 3.4.21.1)
- Trypsin (EC 3.4.21.4)
- Thrombin (EC 3.4.21.5)
- Factor X (EC 3.4.21.6)
- Plasmin (EC 3.4.21.7)
- Acrosin (EC 3.4.21.10)
- Factor VII (EC 3.4.21.21)
- Factor IX (EC 3.4.21.22)
- Prolyl oligopeptidase (EC 3.4.21.26)
- Factor XI (EC 3.4.21.27)
- Elastase (EC 3.4.21.37)
- Factor XII (EC 3.4.21.38)
- Proteinase K (EC 3.4.21.64)
- Tissue plasminogen activator (EC 3.4.21.68)
- Protein C (EC 3.4.21.69)
- Category:EC 3.4.22
- Category:EC 3.4.23
- Category:EC 3.4.24
- Category:EC 3.4.25
Category:EC 3.5 (act on carbon-nitrogen bonds, other than peptide bonds)[]
- Category:EC 3.5.1 (In linear amides)
- Category:EC 3.5.2 (In cyclic amides)
- Category:EC 3.5.3 (In linear amidines)
- Category:EC 3.5.4 (In cyclic amidines)
- Adenosine deaminase (EC 3.5.4.4)
- GTP cyclohydrolase I (EC 3.5.4.16)
- Category:EC 3.5.5 (In nitriles)
Category:EC 3.6 (act on acid anhydrides)[]
- Category:EC 3.6.1
- Helicase
- DnaB helicase
- RecQ helicase
- Category:EC 3.6.3
- ATPase
- NaKATPase (EC 3.6.3.9)
- ATP synthase (EC 3.6.3.14)
Category:EC 3.7 (act on carbon-carbon bonds)[]
Category:EC 3.8 (act on halide bonds)[]
- EC 3.8.1.3 Haloacetate dehalogenase
Category:EC 3.9 (act on phosphorus-nitrogen bonds)[]
Category:EC 3.10 (act on sulfur-nitrogen bonds)[]
Category:EC 3.11 (act on carbon-phosphorus bonds)[]
- EC 3.11.1.1: Phosphonoacetaldehyde hydrolase
- EC 3.11.1.2: Phosphonoacetate hydrolase
- EC 3.11.1.3: Phosphonopyruvate hydrolase
Category:EC 3.12 (act on sulfur-sulfur bonds)[]
Category:EC 3.13 (act on carbon-sulfur bonds)[]
- EC 3.13.1.1: UDP-sulfoquinovose synthase
- EC 3.13.1.3: 2'-hydroxybiphenyl-2-sulfinate desulfinase
- EC 3.13.1.4:
- EC 3.13.1.5: Carbon disulfide hydrolase
- EC 3.13.1.6:
- EC 3.13.1.7: Carbonyl sulfide hydrolase
- EC 3.13.1.8:
Category:Lyases (EC 4) (Lyase)[]
Category:EC 4.1 (carbon-carbon lyases)[]
- Category:EC 4.1.1
- Category:EC 4.1.2
Category:EC 4.2 (carbon-oxygen lyases)[]
Category:EC 4.3 (carbon-nitrogen lyases)[]
- Category:EC 4.3.1
Category:EC 4.4 (carbon-sulfur lyases)[]
- Category:EC 4.4.1
Category:EC 4.5 (carbon-halide lyases)[]
- Category:EC 4.5.1
Category:EC 4.6 (phosphorus-oxygen lyases)[]
- Category:EC 4.6.1
- Adenylate cyclase (EC 4.6.1.1)
- Guanylate cyclase (EC 4.6.1.2)
Category:Isomerases (EC 5) (Isomerase)[]
Category:EC 5.1 (racemases and epimerases)[]
- Category:EC 5.1.1
- Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing)
- Serine racemase
- Category:EC 5.1.2
- Mandelate racemase
- Category:EC 5.1.3
- UDP-glucose 4-epimerase
- Category:EC 5.1.99
- Methylmalonyl CoA epimerase
Category:EC 5.2 (cis-trans-isomerases)[]
- Category:EC 5.2
- FKBP: FKBP1A
- FKBP1B
- FKBP2
- FKBP3
- FKBP4
- FKBP5
- FKBP6
- FKBP8
- FKBP9
- FKBP10
- FKBPL
- Cyclophilin
- Parvulin
- Prolyl isomerase
- 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase
- Beta-carotene isomerase
- Farnesol 2-isomerase
- Furylfuramide isomerase
- Linoleate isomerase
- Maleate isomerase
- Maleylacetoacetate isomerase
- Maleylpyruvate isomerase
- Parvulin
- Photoisomerase
- Prolycopene isomerase
- Prolyl isomerase
- Retinal isomerase
- Retinol isomerase
- Zeta-carotene isomerase
Category:EC 5.3 (intramolecular oxidoreductases)[]
- Category:EC 5.3.3
- Category:EC 5.3.4
Category:EC 5.4 (intramolecular transferases -- mutases)[]
- Category:EC 5.4.2
Category:EC 5.5 (intramolecular lyases)[]
EC number | Examples |
---|---|
EC 5.5.1.1 | Muconate cycloisomerase |
EC 5.5.1.2 | 3-carboxy-cis,cis-muconate cycloisomerase |
EC 5.5.1.3 | Tetrahydroxypteridine cycloisomerase |
EC 5.5.1.4 | Inositol-3-phosphate synthase |
EC 5.5.1.5 | Carboxy-cis,cis-muconate cyclase |
EC 5.5.1.6 | Chalcone isomerase |
EC 5.5.1.7 | Chloromuconate cycloisomerase |
EC 5.5.1.8 | (+)-bornyl diphosphate synthase |
EC 5.5.1.9 | Cycloeucalenol cycloisomerase |
EC 5.5.1.10 | Alpha-pinene-oxide decyclase |
EC 5.5.1.11 | Dichloromuconate cycloisomerase |
EC 5.5.1.12 | Copalyl diphosphate synthase |
EC 5.5.1.13 | Ent-copalyl diphosphate synthase |
EC 5.5.1.14 | Syn-copalyl-diphosphate synthase |
EC 5.5.1.15 | Terpentedienyl-diphosphate synthase |
EC 5.5.1.16 | Halimadienyl-diphosphate synthase |
EC 5.5.1.17 | (S)-beta-macrocarpene synthase |
EC 5.5.1.18 | Lycopene epsilon-cyclase |
EC 5.5.1.19 | Lycopene beta-cyclase |
EC 5.5.1.20 | Prosolanapyrone-III cycloisomerase |
EC 5.5.1.n1 | D-ribose pyranase |
EC 5.5.1.22 | Steroid Delta Isomerase |
Category:EC 5.99 (other isomerases)[]
Category:Ligases (EC 6) (Ligase)[]
Category:EC 6.1 (form carbon-oxygen bonds)[]
6-carboxytetrahydropterin synthase
Category:EC 6.2 (form carbon-sulfur bonds)[]
- EC 6.2.1.1: Acetate--CoA ligase
- EC 6.2.1.2:
- EC 6.2.1.3: Long-chain-fatty-acid-CoA ligase
- EC 6.2.1.4: Succinate-CoA ligase (GDP-forming)
- EC 6.2.1.5: Succinate-CoA ligase (ADP-forming)
- EC 6.2.1.6: Glutarate-CoA ligase
- EC 6.2.1.7: Cholate-CoA ligase
- EC 6.2.1.8: Oxalate-CoA ligase
- EC 6.2.1.9: Malate-CoA ligase
- EC 6.2.1.10: Acid-CoA ligase (GDP-forming)
- EC 6.2.1.11: Biotin-CoA ligase
- EC 6.2.1.12: 4-coumarate-CoA ligase
- EC 6.2.1.13: Acetate-CoA ligase (ADP-forming)
- EC 6.2.1.14: 6-carboxyhexanoate-CoA ligase
- EC 6.2.1.15: Arachidonate-CoA ligase
- EC 6.2.1.16: Acetoacetate-CoA ligase
- EC 6.2.1.17: Propionate-CoA ligase
- EC 6.2.1.18: Citrate-CoA ligase
- EC 6.2.1.19: Long-chain-fatty-acid-luciferin-component ligase
- EC 6.2.1.20: Long-chain-fatty-acid-(acyl-carrier-protein) ligase
- EC 6.2.1.21:
- EC 6.2.1.22: (citrate (pro-3S)-lyase) ligase
- EC 6.2.1.23: Dicarboxylate-CoA ligase
- EC 6.2.1.24: Phytanate-CoA ligase
- EC 6.2.1.25: Benzoate-CoA ligase
- EC 6.2.1.26: o-succinylbenzoate-CoA ligase
- EC 6.2.1.27: 4-hydroxybenzoate-CoA ligase
- EC 6.2.1.28: 3a,7a-dihydroxy-5b-cholestanate-CoA ligase
- EC 6.2.1.29:
- EC 6.2.1.30: Phenylacetate-CoA ligase
- EC 6.2.1.31: 2-furoate-CoA ligase
- EC 6.2.1.32: Anthranilate-CoA ligase
- EC 6.2.1.33: 4-chlorobenzoate-CoA ligase
- EC 6.2.1.34: Trans-feruloyl-CoA synthase
- EC 6.2.1.35: ACP-SH:acetate ligase
- EC 6.2.1.36: 3-hydroxypropionyl-CoA synthase
- EC 6.2.1.37: 3-hydroxybenzoate—CoA ligase
- EC 6.2.1.38: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
- EC 6.2.1.39: (butirosin acyl-carrier protein)—L-glutamate ligase
- EC 6.2.1.40:
- EC 6.2.1.41:
- EC 6.2.1.42:
- EC 6.2.1.43:
- EC 6.2.1.44:
- EC 6.2.1.45: E1 ubiquitin-activating enzyme
- EC 6.2.1.46:
- EC 6.2.1.47:
- EC 6.2.1.48:
- EC 6.2.1.49:
- EC 6.2.1.50:
- EC 6.2.1.51:
- EC 6.2.1.52:
- EC 6.2.1.53:
- EC 6.2.1.54:
- EC 6.2.1.55:
Category:EC 6.3 (form carbon-nitrogen bonds)[]
- Glutamine synthetase (EC 6.3.1.2)
- Argininosuccinate synthetase (EC 6.3.4.5)
- CTP synthase (EC 6.3.4.2)
Category:EC 6.4 (form carbon-carbon bonds)[]
Category:EC 6.5 (form phosphoric ester bonds)[]
Category:EC 6.6 (form nitrogen-metal bonds)[]
- Enzymes