Isochorismatase
| isochorismatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.3.2.1 | ||||||||
| CAS no. | 37288-64-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an isochorismatase (EC 3.3.2.1) is an enzyme that catalyzes the chemical reaction
- isochorismate + H2O 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
Thus, the two substrates of this enzyme are and H2O, whereas its two products are and pyruvate.
This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is isochorismate pyruvate-hydrolase. Other names in common use include 2,3-dihydro-2,3-dihydroxybenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoate synthase, and 2,3-dihydroxy-2,3-dihydrobenzoic synthase. This enzyme participates in the biosynthesis of siderophore group (nonribosomal).
Structural studies[]
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1NF8, 1NF9, and 2FQ1.
References[]
- Young IG, Gibson F (1969). "Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli". Biochim. Biophys. Acta. 177 (3): 401–11. doi:10.1016/0304-4165(69)90302-x. PMID 4306838.
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- EC 3.3.2
- Enzymes of known structure
- Hydrolase stubs