Galactose 1-dehydrogenase (NADP⁺)

In enzymology, a galactose 1-dehydrogenase (NADP⁺) (EC 1.1.1.120) is an enzyme that catalyzes the chemical reaction

D-galactose + NADP⁺ ${\displaystyle \rightleftharpoons }$ D-galactonolactone + NADPH + H⁺

Thus, the two substrates of this enzyme are D-galactose and NADP⁺, whereas its 3 products are , NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-galactose:NADP⁺ 1-oxidoreductase. Other names in common use include D-galactose dehydrogenase (NADP⁺), and galactose 1-dehydrogenase (NADP⁺). This enzyme participates in galactose metabolism.

References[]

• Cline AL, Hu AS (1965). "The isolation of three sugar dehydrogenases from a psuedomonad [sic]". J. Biol. Chem. 240 (11): 4488–92. PMID 5845847.
• Cline AL, Hu AS (1965). "Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4493–7. PMID 5845848.
• Cline AL, Hu AS (1965). "Some physical properties of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4498–502. PMID 5845849.
• Schiwara HW, Domagk GF (1968). "Über den Abbau der Desoxyzucker durch Bakterienenzyme, V. Anreicherung und Charakterisierung einer NADP-abhängigen Abequosedehydrogenase aus Pseudomonas putida" [Degradation of deoxysurgars by bacterial enzymes. V. Purification and characterization of an NADP-dependent abequose dehydrogenase from Pseudomonas putida]. Hoppe-Seyler's Z. Physiol. Chem. (in German). 349 (10): 1321–9. doi:10.1515/bchm2.1968.349.2.1321. PMID 4387016.