Mevaldate reductase
| mevaldate reductase (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.32 | ||||||||
| CAS no. | 9028-33-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a mevaldate reductase (EC 1.1.1.32) is an enzyme that catalyzes the chemical reaction
- (R)-mevalonate + NAD+ mevaldate + NADH + H+
Thus, the two substrates of this enzyme are and NAD+, whereas its 3 products are , NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase. This enzyme is also called mevalonic dehydrogenase.
References[]
- Schlesinger MJ, Coon MJ (1961). "Reduction of mevaldic acid to mevalonic acid by a partial purified enzyme from liver". J. Biol. Chem. 236: 2421–2424.
External links[]
Categories:
- EC 1.1.1
- NADH-dependent enzymes
- Enzymes of unknown structure
- EC 1.1.1 stubs