Immunoglobulin C1-set domain

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Immunoglobulin C1-set domain
Immunoglobulin C1-set domain
	Structure of T-cell surface glycoprotein CD1d antigen.
Identifiers
Symbol	C1-set
Pfam	PF07654
InterPro	IPR003597
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

C1-set domains are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules,^[2]^[3] and in various T-cell receptors.

Human proteins containing this domain[]

AZGP1; B2M; CD1A; ; ; CD1D; CD1E; ; ; ; ; FCGRT; HFE; ; HLA-A; HLA-B; HLA-B35; HLA-B57; HLA-C; ; ; HLA-D; HLA-DMA; HLA-DMB; HLA-DOA; HLA-DOB; HLA-DP; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; ; HLA-DRB3; HLA-DRB4; ; ; HLA-E; HLA-F; HLA-G; ; ; ; IGHA1; IGHA2; IGHD; IGHE; IGHG1; IGHG2; IGHG3; IGHG4; IGHM; ; IGKC; ; ; IGL@; ; ; IGLL1; ; ; ; ; MICA; MICB; ; SIRPA; SIRPB1; SIRPG; ; TAPBP; ; TRBC1; ; ; ; ; ; ;

References[]

^ Zajonc DM, Cantu C, Mattner J, et al. (August 2005). "Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor". Nat. Immunol. 6 (8): 810–8. doi:10.1038/ni1224. PMC 2045075. PMID 16007091.
^ Cresswell P, Pamer E (1998). "Mechanisms of MHC class I--restricted antigen processing". Annu. Rev. Immunol. 16 (1): 323–358. doi:10.1146/annurev.immunol.16.1.323. PMID 9597133.
^ Ono SJ, Radosevich M (2003). "Novel mechanisms of class II major histocompatibility complex gene regulation". Immunol Res. 27 (1): 85–106. doi:10.1385/IR:27:1:85. PMID 12637770. S2CID 5872652.

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This article incorporates text from the public domain Pfam and InterPro: IPR003597

[pmid-1] Zajonc DM, Cantu C, Mattner J, et al. (August 2005). "Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor". Nat. Immunol. 6 (8): 810–8. doi:10.1038/ni1224. PMC 2045075. PMID 16007091.

[PUB00015111-2] Cresswell P, Pamer E (1998). "Mechanisms of MHC class I--restricted antigen processing". Annu. Rev. Immunol. 16 (1): 323–358. doi:10.1146/annurev.immunol.16.1.323. PMID 9597133.

[PUB00015113-3] Ono SJ, Radosevich M (2003). "Novel mechanisms of class II major histocompatibility complex gene regulation". Immunol Res. 27 (1): 85–106. doi:10.1385/IR:27:1:85. PMID 12637770. S2CID 5872652.

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