Integral monotopic protein

Schematic representation of the different types of interaction between monotopic membrane proteins and the cell membrane: 1. interaction by an amphipathic α-helix parallel to the membrane plane (in-plane membrane helix) 2. interaction by a hydrophobic loop 3. interaction by a covalently bound membrane lipid (lipidation) 4. electrostatic or ionic interactions with membrane lipids (e.g. through a calcium ion)

Integral monotopic proteins, are permanently attached to the membrane from one side.^[1]

Three-dimensional structures of the following integral monotopic proteins have been determined:

prostaglandin H2 syntheses 1 and 2 (cyclooxygenases)
lanosterol synthase and squalene-hopene cyclase
microsomal prostaglandin E synthase
carnitine O-palmitoyltransferase 2

There are also structures of integral monotopic domains of transmembrane proteins:

monoamine oxidases A and B
fatty acid amide hydrolase
mammalian cytochrome P450 oxidases
corticosteroid 11-beta-dehydrogenases

References[]

^ Fowler, Philip W.; Coveney, Peter V. (July 2006). "A Computational Protocol for the Integration of the Monotopic Protein Prostaglandin H2 Synthase into a Phospholipid Bilayer". Biophysical Journal. 91 (2): 401–410. doi:10.1529/biophysj.105.077784. PMC 1483072. PMID 16632499.

[fowler-1] Fowler, Philip W.; Coveney, Peter V. (July 2006). "A Computational Protocol for the Integration of the Monotopic Protein Prostaglandin H2 Synthase into a Phospholipid Bilayer". Biophysical Journal. 91 (2): 401–410. doi:10.1529/biophysj.105.077784. PMC 1483072. PMID 16632499.

[1]

v t Proteins
Processes	Protein biosynthesis Post-translational modification Protein folding Protein targeting Proteome Protein methods
Structures	Protein structure Protein structural domains Proteasome
Types	List of types of proteins List of proteins Membrane protein Globular protein Globulin Edestin Albumin Fibrous protein Chromoprotein Photoreceptor protein Biliprotein Phycobiliprotein Phytochrome Lipocalin

v t Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A7
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN2 TSPAN3 TSPAN4 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN12 TSPAN13 TSPAN14 TSPAN18 TSPAN21 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders