Judy Hirst
Judy Hirst | |
---|---|
Education | |
Alma mater | University of Oxford (BA, DPhil) |
Awards | Fellow of the Academy of Medical Sciences (2019) |
Scientific career | |
Institutions | University of Cambridge Scripps Research Institute |
Thesis | Electron transport in redox enzymes (1997) |
Doctoral advisor | Fraser Armstrong[1] |
Website | www |
Judy Hirst FRS FRSC is a British scientist specialising in mitochondrial biology. She is Director[2] of the MRC Mitochondrial Biology Unit at the University of Cambridge.
Education and early life[]
Hirst grew up in Lepton, a village near Huddersfield, West Yorkshire, and attended King James's School and Greenhead College,[3] Huddersfield and studied for an M.A. in chemistry at St John's College, Oxford.[2] Hirst then was awarded a Doctor of Philosophy degree at Lincoln College, Oxford for research supervised by Fraser Armstrong on the electron transport in redox enzymes in 1997.[1]
Career and research[]
Following her D.Phil., Hirst held a fellowship at the Scripps Research Institute in California, before moving to Cambridge.[4]
As of 2018 Hirst is Dean of the College and Fellow and Director of Studies in Chemistry at Corpus Christi College, Cambridge,[4] having served 5 years as Depute Director, and three years as Assistant Director. Her main research interest is mitochondrial complex I.[2]
Publications[]
Hirst has been published in 2018 on Open questions: respiratory chain supercomplexes - why are they there and what do they do? [5] and working with Justin Fedor, published research on mitochondrial supercomplexes in Cell Metabolism.[6] Recent research in her team includes a study, published in May 2020 by the American Chemical Society Synthetic Biology on 'Adenosine triphosphate (ATP), the cellular energy currency, is essential for life. The ability to provide a constant supply of ATP is therefore crucial for the construction of artificial cells in synthetic biology' which has developed a 'minimal system for cellular respiration and energy regeneration'.[7] A full list of Hirst's publications are on her MRC webpage.
Awards and honours[]
Early in her career, Hirst was awarded EMBO Young Investigator Award (2001) and Young Investigator Award from the Royal Society of Chemistry Inorganic Biochemistry Discussion Group (2006).[8]
Hirst was elected a Fellow of the Royal Society (FRS) in 2018.[9] She was awarded an Interdisciplinary Prize of the Royal Society of Chemistry in the same year.[10] In 2019, Hirst was elected Fellow of the Academy of Medical Sciences[11] which was cited as 'Judy Hirst, Professor of Biological Chemistry at the MRC Mitochondrial Biology Unit, Cambridge, has had a definitive hand in every advance towards defining the highly complex mechanism of complex I catalysis, and has developed new physical and biochemical methods to address the elusive coupling mechanism between the redox reaction and proton translocation. She established the mechanism of complex I inhibition by the anti-diabetic drug metformin, and has used kinetic and thermodynamic strategies to define how superoxide production by complex I, responds to the intramitochondrial NADH/NAD+ ratio to directly link two pathological effects of complex I dysfunction. This seminal work has brought understanding that is fundamental to critical issues of health and disease on a global stage.' [12]
Hirst was awarded Keilin Memorial Lecture and Medal in 2020 for research which 'has made pivotal contributions to understanding energy conversion in complex redox enzymes: how they capture the energy released by a redox reaction to power proton translocation across a membrane, or catalyse the interconversion of chemical bond energy and electrical potential. She is known particularly for her work on mammalian respiratory complex I (NADH: ubiquinone oxidoreductase), an energy-transducing, mitochondrial redox enzyme of fundamental and medical importance, and for solving its structure by electron cryomicroscopy'.[13]
External links[]
- Publications http://www.mrc-mbu.cam.ac.uk/people/judy-hirst/publications
- Keilin Memorial Award https://www.biochemistry.org/grants-and-awards/awards/the-keilin-memorial-lecture/
References[]
- ^ Jump up to: a b Hirst, Judy (1997). Electron transport in redox enzymes. bodleian.ox.ac.uk (DPhil thesis). University of Oxford. OCLC 557413704. EThOS uk.bl.ethos.364043.
- ^ Jump up to: a b c "Judy Hirst FRS | MRC Mitochondrial Biology Unit". www.mrc-mbu.cam.ac.uk. Retrieved 2020-08-16.
- ^ "Dr Judy Hirst MA, DPhil, FRS". www.greenhead.ac.uk. Retrieved 2020-08-16.
- ^ Jump up to: a b "Dr Judy Hirst MA, DPhil (Oxon), FRSC". Corpus Christi College. Retrieved 10 May 2018.
- ^ Hirst, Judy (2018). "Open questions: respiratory chain supercomplexes-why are they there and what do they do?". BMC Biol. 16 (1): 111. doi:10.1186/s12915-018-0577-5. ISSN 1741-7007. PMC 6211484. PMID 30382836.
- ^ Fedor, Justin; Hirst, Judy (2018). "Mitochondrial Supercomplexes Do Not Enhance Catalysis by Quinone Channeling". Cell Metab. 28 (3): 525–531.e4. doi:10.1016/j.cmet.2018.05.024. ISSN 1932-7420. PMC 6125145. PMID 29937372.
- ^ Biner, Olivier; Fedor, Justin G.; Yin, Zhan; Hirst, Judy (2020-06-19). "Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration". ACS Synthetic Biology. 9 (6): 1450–1459. doi:10.1021/acssynbio.0c00110. PMID 32383867.
- ^ "RSC Interdisciplinary Prize 2018 Winner". www.rsc.org. Retrieved 2020-08-16.
- ^ "Judy Hirst". royalsociety.org. Retrieved 10 May 2018.
- ^ "2018 Interdisciplinary Prize Winner: Dr Judy Hirst". Royal Society of Chemistry. Retrieved 10 May 2018.
- ^ "New Fellows: 50 top biomedical and health scientists join the Academy | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2020-08-16.
- ^ "Professor Judy Hirst | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2020-08-16.
- ^ "Professor Judy Hirst FRS receives Keilin Memorial Lecture Award". Corpus Christi College University of Cambridge. 2019-04-01. Retrieved 2020-08-16.
- 21st-century biologists
- 21st-century English scientists
- 21st-century British women scientists
- Cell biologists
- English biologists
- English women biologists
- Living people
- Alumni of St John's College, Oxford
- Fellows of Corpus Christi College, Cambridge
- Female Fellows of the Royal Society
- Fellows of the Royal Society
- Fellows of the Royal Society of Chemistry
- Fellows of the Academy of Medical Sciences (United Kingdom)
- 21st-century English women