Dimitri Kullmann

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Dimitri Kullmann

FRS FMedSci MAE
Dimitri Kullmann Royal Society.jpg
Dimitri Kullmann at the Royal Society, London, 2018
Born
Dimitri Michael Kullmann

1958 (age 62–63)[1]
London, England[1]
EducationLycée Français Charles de Gaulle[1]
Alma materUniversity of Oxford (BM BCh, DPhil)
AwardsBaly Medal (2017)[2]
Scientific career
Fields
Institutions
ThesisCentral actions of muscle receptors (1984)
Doctoral advisorJulian Jack[4]
InfluencesRoger Nicoll[2]
Websitewww.ucl.ac.uk/ion/research/synaptopathies/principal-investigators/dimitri-m-kullmann

Dimitri Michael Kullmann (born 1958)[1] FRS FMedSci MAE is a professor of neurology at the UCL Institute of Neurology,[2] University College London (UCL), and leads the synaptopathies initiative funded by the Wellcome Trust.[5] Kullmann is a member of the Queen Square Institute of Neurology Department of Clinical and Experimental Epilepsy[6] and a consultant neurologist at the National Hospital for Neurology and Neurosurgery.[3][7]

Education[]

Kullmann was educated at the Lycée Français Charles de Gaulle[1] and studied physiology at Balliol College, Oxford[1] where he was awarded a Bachelor of Arts (BA) degree and a Doctor of Philosophy degree.[4] He studied and trained at the University of Oxford and St Thomas's Hospital Medical School at the University of London.[2] His postgraduate research was supervised by Julian Jack.[4]

Research and career[]

Kullmann's research[3][8] investigates how synapses function in health and disease.[9] His laboratory helped to show how neurotransmitters activate different receptor subtypes in and around synapses, and resolved some controversies about the mechanisms of long-term changes in synaptic strength.[9] Genetic and autoimmune disorders of synaptic proteins (‘synaptopathies’) provide insights into the mechanisms of a broad range of neurological diseases including epilepsy and migraine.[9] Together with his colleagues, Kullmann has used these insights to devise gene therapy strategies that could be used to treat intractable epilepsy.[9][3]

The Kullmann lab[3][8] has contributed to the discovery and elucidation of silent synapses,[10] glutamate spillover, tonic inhibition,[11] long-term potentiation in interneurons,[12] neurological channelopathies[13] and Synaptopathies, gene therapy for epilepsy,[14] and mechanisms of neural oscillations.[15] Kullmann served as the editor-in-chief of the scientific journal Brain between 2014 and 2020[16] and is on the editorial board of the journal Neuron.[17] Before working at UCL, he did postdoctoral research with Roger Nicoll at the University of California, San Francisco.[2]

Awards and honours[]

Kullmann was awarded the University Gold Medal in Medicine by the University of London, in 1986.[2] and the Baly Medal by the Royal College of Physicians in 2017.[2] He was elected a Guarantor of Brain in 2000,[18] elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2001,[19] a Corresponding Fellow of the American Neurological Association in 2013,[20] a member of the Academia Europaea (MAE) in 2017[21] and a Fellow of the Royal Society (FRS) in 2018.[9]

References[]

  1. ^ Jump up to: a b c d e f Anon (2019). "Kullmann, Prof. Dimitri Michael". Who's Who. ukwhoswho.com (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription or UK public library membership required) (subscription required)
  2. ^ Jump up to: a b c d e f g h "Prof Dimitri Michael Kullmann: Iris View Profile". University College London. Retrieved 2 October 2016.
  3. ^ Jump up to: a b c d e f g h Dimitri Kullmann publications indexed by Google Scholar Edit this at Wikidata
  4. ^ Jump up to: a b c Kullman, Dimitri Michael (1984). Central actions of muscle receptors (DPhil thesis). University of Oxford. OCLC 59330270. EThOS uk.bl.ethos.353099.
  5. ^ "Synaptopathies". University College London. 17 July 2014. Retrieved 2 October 2016.
  6. ^ "DCEE". University College London. Retrieved 7 June 2021.
  7. ^ Dimitri Kullmann publications from Europe PubMed Central
  8. ^ Jump up to: a b Dimitri Kullmann publications from Europe PubMed Central
  9. ^ Jump up to: a b c d e Anon (2018). "Professor Dimitri Kullmann FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 24 May 2018. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  10. ^ Kullmann, Dimitri M. (1994). "Amplitude fluctuations of". Neuron. 12 (5): 1111–1120. doi:10.1016/0896-6273(94)90318-2. PMID 7910467. S2CID 54357872.
  11. ^ Semyanov, Alexey; Walker, Matthew C.; Kullmann, Dimitri M.; Silver, R.Angus (2004). "Tonically active GABAA receptors: modulating gain and maintaining the tone". Trends in Neurosciences. 27 (5): 262–269. doi:10.1016/j.tins.2004.03.005. ISSN 0166-2236. PMID 15111008. S2CID 2660172.
  12. ^ Lamsa, Karri P.; Heeroma, Joost H.; Somogyi, Peter; Rusakov, Dmitri A.; Kullmann, Dimitri M. (2007). "Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit". Science. 315 (5816): 1262–1266. Bibcode:2007Sci...315.1262L. doi:10.1126/science.1137450. ISSN 1095-9203. PMC 3369266. PMID 17332410.
  13. ^ Kullmann, Dimitri M. (2010). "Neurological channelopathies". Annual Review of Neuroscience. 33: 151–172. doi:10.1146/annurev-neuro-060909-153122. ISSN 1545-4126. PMID 20331364.
  14. ^ Wykes, Robert C.; Heeroma, Joost H.; Mantoan, Laura; Zheng, Kaiyu; MacDonald, Douglas C.; Deisseroth, Karl; Hashemi, Kevan S.; Walker, Matthew C.; Schorge, Stephanie (2012). "Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy". Science Translational Medicine. 4 (161): 161ra152. doi:10.1126/scitranslmed.3004190. ISSN 1946-6242. PMC 3605784. PMID 23147003.
  15. ^ Akam, Thomas; Oren, Iris; Mantoan, Laura; Ferenczi, Emily; Kullmann, Dimitri M. (2012). "Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling". Nature Neuroscience. 15 (5): 763–768. doi:10.1038/nn.3081. ISSN 1546-1726. PMC 3378654. PMID 22466505.
  16. ^ "Editorial board | Brain". Brain.oxfordjournals.org. 26 September 2016. Archived from the original on 11 October 2014. Retrieved 2 October 2016.
  17. ^ "Editorial Board: Neuron". cell.com.
  18. ^ "Guarantors of Brain". Guarantors of Brain. Retrieved 11 August 2016.
  19. ^ "Professor Dimitri Kullmann FMedSci". acmedsci.ac.uk. Retrieved 2 October 2016.
  20. ^ "American Neurological Association (ANA)". Myana.org. Retrieved 1 November 2016.
  21. ^ Hoffmann, Ilire Hasani, Robert. "Academy of Europe: Kullmann Dimitri". ae-info.org.

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