Lymphangiogenesis

Lymphangiogenesis
Lymphangiogenesis
Identifiers
MeSH	D042583
	Anatomical terminology [edit on Wikidata]

Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels^[1] in a method believed to be similar to angiogenesis (blood vessel development).^[2]

Lymphangiogenesis plays an important physiological role in homeostasis, metabolism and immunity. Impaired or excessive lymphatic vessel formation has been implicated in a number of pathological conditions including neoplasm metastasis,^[3] oedema, rheumatoid arthritis, psoriasis, lymphangiomatosis and impaired wound healing.

The role of the lymphatic system in these diseases has received renewed interest largely due to the discovery of (LEC)-specific markers such as podoplanin, LYVE-1, PROX1, desmoplakin and VEGF-C receptor VEGFR-3.^[4] These specific markers have enabled insights into functional and molecular lymphatic biology. There are several known pro-lymphangiogenesis inducers such as VEGF-C, hyaluronic acid and ephrin-B2.^{[citation needed]}

References[]

^ Michael Jeltsch; Tuomas Tammela; Kari Alitalo; Jörg Wilting (2003). "Genesis and pathogenesis of lymphatic vessels". Cell and Tissue Research. 314 (1): 69–84. doi:10.1007/s00441-003-0777-2. PMID 12942362. S2CID 23318096.
^ "Lymphatic vasculature development" (PDF). Retrieved 17 December 2018.
^ Steven A. Stacker (1 July 2009). Lymphangiogenesis in Cancer Metastasis. Springer. pp. 27–. ISBN 978-90-481-2246-2. Retrieved 26 June 2010.
^ Jha, Sawan K.; Rauniyar, Khushbu; Jeltsch, Michael (2018). "Key molecules in lymphatic development, function, and identification". Annals of Anatomy - Anatomischer Anzeiger. 219: 25–34. doi:10.1016/j.aanat.2018.05.003. PMID 29842991.

Further reading[]

Lymphangiogenesis and disease

Plate, Karl H (2001). "From angiogenesis to lymphangiogenesis". Nature Medicine. 7 (2): 151–152. doi:10.1038/84579. PMID 11175837. S2CID 27646199.
Jell, Gavin; Kerjaschki, Dontscho; Revell, Peter; Al-Saffar, Najat (2006). "Lymphangiogenesis in the bone–implant interface of orthopedic implants: Importance and consequence". Journal of Biomedical Materials Research Part A. 77A (1): 119–127. doi:10.1002/jbm.a.30548. PMID 16392126.
Ji, Rui-Cheng (2006). "Lymphatic Endothelial Cells, Lymphangiogenesis, and Extracellular Matrix". Lymphatic Research and Biology. 4 (2): 83–100. doi:10.1089/lrb.2006.4.83. PMID 16808670.

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[Jeltsch2003-1] Michael Jeltsch; Tuomas Tammela; Kari Alitalo; Jörg Wilting (2003). "Genesis and pathogenesis of lymphatic vessels". Cell and Tissue Research. 314 (1): 69–84. doi:10.1007/s00441-003-0777-2. PMID 12942362. S2CID 23318096.

[Columbia-2] "Lymphatic vasculature development" (PDF). Retrieved 17 December 2018.

[Stacker2009-3] Steven A. Stacker (1 July 2009). Lymphangiogenesis in Cancer Metastasis. Springer. pp. 27–. ISBN 978-90-481-2246-2. Retrieved 26 June 2010.

[4] Jha, Sawan K.; Rauniyar, Khushbu; Jeltsch, Michael (2018). "Key molecules in lymphatic development, function, and identification". Annals of Anatomy - Anatomischer Anzeiger. 219: 25–34. doi:10.1016/j.aanat.2018.05.003. PMID 29842991.

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