MMP28

MMP28
Identifiers
Aliases	MMP28, EPILYSIN, MM28, MMP-25, MMP-28, MMP25, matrix metallopeptidase 28
External IDs	OMIM: 608417 MGI: 2153062 HomoloGene: 41559 GeneCards: MMP28
Gene location (Human)
Chr.	Chromosome 17 (human)
End	35,795,707 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	83,353,897 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; esophagus; ; sural nerve; ; lung; ; upper lobe of left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metallopeptidase activity; metalloendopeptidase activity; zinc ion binding; metal ion binding; GO:0001948 protein binding;
Cellular component	extracellular region; cytoplasm; GO:0005578 extracellular matrix; collagen-containing extracellular matrix; extracellular space;
Biological process	proteolysis; negative regulation of macrophage chemotaxis; extracellular matrix organization; collagen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	79148
	118453
	ENSG00000278843; ENSG00000271447
	ENSMUSG00000020682
	Q9H239
	n/a
	NM_001032278; NM_024302; NM_032950
	NM_080453; NM_172797; NM_001320300
	NP_001027449; NP_077278; NP_116568; NP_116568.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Matrix metalloproteinase 28 also known as epilysin is an enzyme that in humans is encoded by the MMP28 gene.^[5]^[6]^[7]

Function[]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding different isoforms have been described.^[7]

References[]

^ ^a ^b ^c ENSG00000271447 GRCh38: Ensembl release 89: ENSG00000278843, ENSG00000271447 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020682 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lohi J, Wilson CL, Roby JD, Parks WC (Mar 2001). "Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury". J Biol Chem. 276 (13): 10134–44. doi:10.1074/jbc.M001599200. PMID 11121398.
^ Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene. 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011.
^ ^a ^b "Entrez Gene: MMP28 matrix metallopeptidase 28".

External links[]

The MEROPS online database for peptidases and their inhibitors: M10.030

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] ENSG00000271447 GRCh38: Ensembl release 89: ENSG00000278843, ENSG00000271447 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020682 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11121398-5] Lohi J, Wilson CL, Roby JD, Parks WC (Mar 2001). "Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury". J Biol Chem. 276 (13): 10134–44. doi:10.1074/jbc.M001599200. PMID 11121398.

[pmid11255011-6] Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene. 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011.

[entrez-7] "Entrez Gene: MMP28 matrix metallopeptidase 28".

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v t Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

MMP28

Contents

Function[]

References[]

Further reading[]

External links[]