ADAM18

ADAM18
Identifiers
Aliases	ADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18
External IDs	MGI: 105986 HomoloGene: 74941 GeneCards: ADAM18
Gene location (Human)
Chr.	Chromosome 8 (human)
End	39,730,065 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	25,164,771 bp
RNA expression pattern
	Top expressed in
	testicle; ; left ventricle; ; ovary; ; gastrocnemius muscle; ; substantia nigra; ; central nervous system; ; cerebral cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metalloendopeptidase activity; metallopeptidase activity;
Cellular component	integral component of membrane; membrane;
Biological process	multicellular organism development; cell differentiation; spermatogenesis; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	8749
	13524
	ENSG00000168619; ENSG00000278548
	ENSMUSG00000031552
	Q9Y3Q7
	Q9R157
	NM_001190956; NM_014237; NM_001320313
	NM_010084
	NP_001177885; NP_001307242; NP_055052
	NP_034214
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.^[5]^[6]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.^[6]

References[]

^ ^a ^b ^c ENSG00000278548 GRCh38: Ensembl release 89: ENSG00000168619, ENSG00000278548 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031552 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod. 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459.
^ ^a ^b "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18".

External links[]

The MEROPS online database for peptidases and their inhibitors: M12.957
Human ADAM18 genome location and ADAM18 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] ENSG00000278548 GRCh38: Ensembl release 89: ENSG00000168619, ENSG00000278548 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031552 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12200459-5] Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod. 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459.

[entrez-6] "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18".

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v t Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

ADAM18

References[]

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