Maduropeptin

(−)-Maduropeptin chromophore C-5 methanol adduct

Maduropeptin consists of a 1:1 complex of a carrier protein (MdpA) and a chromophore isolated from .^[1] The chromophore has an enediyne structure and is an antibiotic with anticancer activity.

References[]

^ Ling, J; Horsman, G. P; Huang, S. X; Luo, Y; Lin, S; Shen, B (2010). "Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate". Journal of the American Chemical Society. 132 (36): 12534–6. doi:10.1021/ja1050814. PMC 2935939. PMID 20718468.

External links[]

Maduropeptin chromophore at ChemSpider

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[1] Ling, J; Horsman, G. P; Huang, S. X; Luo, Y; Lin, S; Shen, B (2010). "Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate". Journal of the American Chemical Society. 132 (36): 12534–6. doi:10.1021/ja1050814. PMC 2935939. PMID 20718468.

[1]

v t Enediynes
9 membered rings	C-1027 Kedarcidin Maduropeptin Neocarzinostatin
10 membered rings	Calicheamicin Dynemicin A Esperamicin Shishijimicin A