Minigastrin
Identifiers | |
---|---|
| |
3D model (JSmol)
|
|
ChemSpider | |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C70H91N15O26 | |
Molar mass | 1558.56 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
what is ?) | (|
Infobox references | |
Minigastrin (also mini gastrin) is a form of gastrin. Its sequence is H-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2.[1]
Minigastrin has shown to be a potential therapeutic agent for thyroid carcinoma by targeting cancer-promoting cholecystokinin receptors.[2] A 2018 study further elaborates by using radiochemical labeling to show that Indium-111 labeled minigastrin peptides showing to have stronger affinity to cholecystokinin B receptors (CCK2) in neuroendocrine cancers.[3]
References[]
- ^ Oxford dictionary of biochemistry and molecular biology (Rev. ed.). Oxford University Press. ISBN 9780198529170.
- ^ von Guggenberg, Elisabeth; Rangger, Christine; Sosabowski, Jane; Laverman, Peter; Reubi, Jean-Claude; Virgolini, Irene Johanna; Decristoforo, Clemens (6 July 2011). "Preclinical Evaluation of Radiolabeled DOTA-Derivatized Cyclic Minigastrin Analogs for Targeting Cholecystokinin Receptor Expressing Malignancies". Molecular Imaging and Biology. 14 (3): 366–375. doi:10.1007/s11307-011-0506-2.
- ^ Rizvi, Syed Faheem Askari; Naqvi, Syed Ali Raza; Roohi, Samina; Sherazi, Tauqir A.; Rasheed, Rashid (24 August 2018). "177Lu-DOTA-coupled minigastrin peptides: promising theranostic agents in neuroendocrine cancers". Molecular Biology Reports. 45 (6): 1759–1767. doi:10.1007/s11033-018-4319-0.
Categories:
- Peptide hormones
- Biochemistry stubs