From Wikipedia, the free encyclopedia
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin .[1] There are two different subtypes CCKA and CCKB which are ~50% homologous :[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide .
protein
gene
tissue distribution
preferred ligand
function
CCKA (CCK1 )
CCKAR
primarily gastrointestinal tract , lesser amounts in the CNS
sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK
stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility
CCKB (CCK2 )
CCKBR
primarily CNS, lesser amounts in the gastrointestinal tract
gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides)
regulation of nociception , anxiety , memory and hunger
References [ ]
^ Noble F, Wank SA, Crawley JN , Bradwejn J, Seroogy KB, Hamon M, Roques BP (December 1999). "International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors" . Pharmacological Reviews . 51 (4): 745–81. PMID 10581329 .
^ Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev . 86 (3): 805–47. doi :10.1152/physrev.00014.2005 . PMID 16816139 .
External links [ ]
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