GPR156 Identifiers Aliases GPR156 External IDs OMIM : 610464 MGI : 2653880 HomoloGene : 17683 GeneCards : GPR156 Gene location (Human ) Chr. Chromosome 3 (human) [1] Band 3q13.33 Start 120,164,645 bp [1] End 120,285,222 bp [1]
Gene location (Mouse ) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 37,736,858 bp [2] End 37,827,892 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 3: 120.16 – 120.29 Mb Chr 16: 37.74 – 37.83 Mb PubMed search[3] [4] Wikidata
GPR156 (G protein-coupled receptor 156), is a human gene which encodes a G protein-coupled receptor belonging to metabotropic glutamate receptor subfamily.[5] sequence homology , this gene was proposed as being a possible GABAB receptor subunit, however when expressed in cells alone or with other GABAB subunits, no response to GABAB ligands could be detected. Therefore, the function of this protein remains to be elucidated.[6] Gi/Go heterotrimeric G protein family.[7]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000175697 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046961 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: GPR156 G protein-coupled receptor 156" .^ Calver AR, Michalovich D, Testa TT, Robbins MJ, Jaillard C, Hill J, Szekeres PG, Charles KJ, Jourdain S, Holbrook JD, Boyfield I, Patel N, Medhurst AD, Pangalos MN (2003). "Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor". Brain Res. Mol. Brain Res . 110 (2): 305–17. doi :10.1016/S0169-328X(02)00662-9 . PMID 12591167 . ^ Watkins, Lyndsay R.; Orlandi, Cesare (2021-03-30). "In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity" . British Journal of Pharmacology . 178 (15): 2963–2975. doi :10.1111/bph.15468 . ISSN 1476-5381 . PMID 33784795 . S2CID 232430996 .
Further reading [ ]
Calver AR, Michalovich D, Testa TT, Robbins MJ, Jaillard C, Hill J, Szekeres PG, Charles KJ, Jourdain S, Holbrook JD, Boyfield I, Patel N, Medhurst AD, Pangalos MN (2003). "Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor". Brain Res. Mol. Brain Res . 110 (2): 305–17. doi :10.1016/S0169-328X(02)00662-9 . PMID 12591167 . Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (2003). "The G protein-coupled receptor repertoires of human and mouse" . Proc. Natl. Acad. Sci. U.S.A . 100 (8): 4903–8. Bibcode :2003PNAS..100.4903V . doi :10.1073/pnas.0230374100 PMC 153653 PMID 12679517 .
Cell surface receptor : G protein-coupled receptors
Neurotransmitter
Adrenergic
α1 (A B D )α2 (A B C )β1 β2 β3 Purinergic
Adenosine (A1 A2A A2B A3 )P2Y (1 2 4 5 6 8 9 10 11 12 13 14 ) Serotonin Other
Acetylcholine (M1 M2 M3 M4 M5 )Dopamine
GHB receptor Histamine
Melatonin (1A 1B 1C )TAAR (1 2 5 6 8 9 )
Metabolites and
Eicosanoid
CysLT (1 2 )LTB4
FPRL1 OXE Prostaglandin
DP (1 2 ), EP (1 2 3 4 ), FP Prostacyclin Thromboxane Other
Peptide
Miscellaneous
Taste , sweetOther
Calcium-sensing receptor GABAB (1 2 )Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8 ))GPRC6A GPR (156 158 179 )RAIG (1 2 3 4 )
