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GPR12 Identifiers Aliases GPR12 , GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12External IDs OMIM : 600752 MGI : 101909 HomoloGene : 3868 GeneCards : GPR12 Gene location (Human ) Chr. Chromosome 13 (human) [1] Band 13q12.13 Start 26,755,200 bp [1] End 26,760,786 bp [1]
Gene location (Mouse ) Chr. Chromosome 5 (mouse)[2] Band 5|5 G3 Start 146,519,208 bp [2] End 146,522,049 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 13: 26.76 – 26.76 Mb Chr 5: 146.52 – 146.52 Mb PubMed search[3] [4] Wikidata
Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene .[5] [6] [7]
The gene product of GPR12 is an orphan receptor , meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.[8]
Ligands [ ]
Inverse agonists
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000132975 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041468 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system" . FEBS Letters . 336 (2): 317–22. doi :10.1016/0014-5793(93)80828-I . PMID 8262253 . S2CID 31345248 .
^ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors" . Genomics . 28 (2): 347–9. doi :10.1006/geno.1995.1154 . PMID 8530049 .
^ "Entrez Gene: GPR12 G protein-coupled receptor 12" .
^ Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications . 348 (2): 359–66. doi :10.1016/j.bbrc.2006.07.090 . PMID 16887097 .
^ Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12" . Biochemical and Biophysical Research Communications . 493 (1): 451–454. doi :10.1016/j.bbrc.2017.09.001 . PMC 5849771 . PMID 28888984 .
Further reading [ ]
Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry . 13 (2): 75–84. doi :10.1159/000070251 . PMID 12649592 . S2CID 45156405 .
Cell surface receptor : G protein-coupled receptors
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Categories :
Genes on human chromosome 13 G protein-coupled receptors Transmembrane receptor stubs