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GPR148 Identifiers Aliases GPR148 , BTR, PGR6, G protein-coupled receptor 148External IDs HomoloGene : 131347 GeneCards : GPR148 Gene location (Human ) Chr. Chromosome 2 (human) [1] Band 2q21.1 Start 130,729,070 bp [1] End 130,730,336 bp [1]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 2: 130.73 – 130.73 Mb n/a PubMed search[2] n/a Wikidata
G protein-coupled receptor 148 , also known as GPR148 , is a human orphan receptor from GPCR superfamily.[3] It is expressed primarily in nervous system and testis . Is may be implicated in prostate cancer .
References [ ]
Further reading [ ]
Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence" . FEBS Lett . 520 (1–3): 97–101. doi :10.1016/S0014-5793(02)02775-8 . PMID 12044878 . S2CID 7116392 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse" . Proc. Natl. Acad. Sci. U.S.A . 100 (8): 4903–8. Bibcode :2003PNAS..100.4903V . doi :10.1073/pnas.0230374100 . PMC 153653 . PMID 12679517 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Parmigiani RB, Magalhães GS, Galante PA, et al. (2005). "A novel human G protein-coupled receptor is over-expressed in prostate cancer". Genet. Mol. Res . 3 (4): 521–31. PMID 15688318 .
Gloriam DE, Schiöth HB, Fredriksson R (2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochim. Biophys. Acta . 1722 (3): 235–46. doi :10.1016/j.bbagen.2004.12.001 . PMID 15777626 .
Cell surface receptor : G protein-coupled receptors
Neurotransmitter
Adrenergic
α1 (A
B
D )
α2 (A
B
C )
β1
β2
β3
Purinergic
Adenosine (A1
A2A
A2B
A3 )
P2Y (1
2
4
5
6
8
9
10
11
12
13
14 )
Serotonin Other
Acetylcholine (M1
M2
M3
M4
M5 )
Dopamine
GHB receptor
Histamine
Melatonin (1A
1B
1C )
TAAR (1
2
5
6
8
9 )
Metabolites and signaling molecules
Eicosanoid
CysLT (1
2 )
LTB4
FPRL1
OXE
Prostaglandin
DP (1
2 ), EP (1
2
3
4 ), FP
Prostacyclin
Thromboxane
Other
Peptide
Miscellaneous
Taste , sweetOther
Calcium-sensing receptor
GABAB (1
2 )
Glutamate receptor (Metabotropic glutamate (1
2
3
4
5
6
7
8 ))
GPRC6A
GPR (156
158
179 )
RAIG (1
2
3
4 )
Categories :
Genes on human chromosome 2 G protein-coupled receptors Transmembrane receptor stubs