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The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones.[1] [2]
Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.
receptor/gene
ligands
activates
inhibits
RXFP1
relaxin 1, relaxin 2, relaxin 3
adenylate cyclase , protein kinase A , protein kinase C ,
phosphatidylinositol 3-kinase , extracellular signal-regulated kinases (Erk1/2)
RXFP2
relaxin 1, relaxin 2, insulin-like 3
adenylate cyclase
RXFP3
relaxin 3
Erk1/2 signaling
adenylate cyclase
RXFP4
relaxin 3, insulin-like 3
adenylate cyclase
See also [ ]
References [ ]
External links [ ]
Cell surface receptor : G protein-coupled receptors
Neurotransmitter
Adrenergic
α1 (A
B
D )
α2 (A
B
C )
β1
β2
β3
Purinergic
Adenosine (A1
A2A
A2B
A3 )
P2Y (1
2
4
5
6
8
9
10
11
12
13
14 )
Serotonin Other
Acetylcholine (M1
M2
M3
M4
M5 )
Dopamine
GHB receptor
Histamine
Melatonin (1A
1B
1C )
TAAR (1
2
5
6
8
9 )
Metabolites and signaling molecules
Eicosanoid
CysLT (1
2 )
LTB4
FPRL1
OXE
Prostaglandin
DP (1
2 ), EP (1
2
3
4 ), FP
Prostacyclin
Thromboxane
Other
Peptide
Miscellaneous
Taste , sweetOther
Calcium-sensing receptor
GABAB (1
2 )
Glutamate receptor (Metabotropic glutamate (1
2
3
4
5
6
7
8 ))
GPRC6A
GPR (156
158
179 )
RAIG (1
2
3
4 )
Categories :
Genes on human chromosome 4 Genes on human chromosome 13 Genes on human chromosome 5 Genes on human chromosome 1 G protein-coupled receptors Transmembrane receptor stubs Hidden categories:
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