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LPAR5 Identifiers Aliases LPAR5 , GPR92, GPR93, KPG_010, LPA5, lysophosphatidic acid receptor 5External IDs OMIM : 606926 MGI : 2685918 HomoloGene : 10696 GeneCards : LPAR5 Gene location (Human ) Chr. Chromosome 12 (human) [1] Band 12p13.31 Start 6,618,835 bp [1] End 6,635,960 bp [1]
Gene location (Mouse ) Chr. Chromosome 6 (mouse)[2] Band 6|6 F2 Start 125,044,883 bp [2] End 125,059,435 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 12: 6.62 – 6.64 Mb Chr 6: 125.04 – 125.06 Mb PubMed search[3] [4] Wikidata
Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene .[5] [6] [7] [8] [9] LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[10]
See also [ ]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000184574 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067714 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ White, Kenneth E.; Evans, Wayne E.; O'Riordan, Jeffery L.H.; Speer, Marcy C.; Econs, Michael J.; Lorenz-Depiereux, Bettina; Grabowski, Monika; Meitinger, Thomas; Strom, Tim M. (Dec 2000). "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nat Genet . 26 (3): 345–8. doi :10.1038/81664 . PMID 11062477 . S2CID 38870810 .
^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene . 275 (1): 83–91. doi :10.1016/S0378-1119(01)00651-5 . PMID 11574155 .
^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (Aug 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5" . J Biol Chem . 281 (33): 23589–97. doi :10.1074/jbc.M603670200 . PMID 16774927 .
^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (Jul 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". J Pharmacol Exp Ther . 318 (2): 619–28. doi :10.1124/jpet.105.098848 . PMID 16651401 . S2CID 5989815 .
^ "Entrez Gene: GPR92 G protein-coupled receptor 92" .
^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology . 50 (1): 157–186. doi :10.1146/annurev.pharmtox.010909.105753 . PMID 20055701 .
Further reading [ ]
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Genes on human chromosome 12 G protein-coupled receptors Transmembrane receptor stubs