The MAS1 oncogene (MAS receptor) is a G protein-coupled receptor,[1][2] which binds the angiotensin-II metabolite Angiotensin (1-7).[3][4] The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor. Hence MAS1 receptor agonists have similar therapeutic effects as angiotensin-II receptor antagonists including lowering blood pressure.[5]
References[]
^Nunes-Silva A, Rocha GC, Magalhaes DM, Vaz LN, Salviano de Faria MH, Simoes e Silva AC (November 2017). "Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System". Protein and Peptide Letters. Bentham Science Publishers Ltd. 24 (9): 809–816. doi:10.2174/0929866524666170728151401. PMID28758593. (2) a counter-regulatory or vasodilator pathway comprising angiotensin-converting enzyme 2 (ACE2), Angiotensin-(1-7) [Ang-(1-7)] and Mas receptor, which is involved in vasodilation, antiproliferation, anti-hypertrophy, cardioprotective and renoprotective actions.
^Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (June 1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID3708691. S2CID29886272.
^Santos RA, Ferreira AJ (March 2007). "Angiotensin-(1-7) and the renin-angiotensin system". Current Opinion in Nephrology and Hypertension. 16 (2): 122–8. doi:10.1097/MNH.0b013e328031f362. PMID17293687. S2CID32812104.
