GPR78 Identifiers Aliases GPR78 , G protein-coupled receptor 78External IDs OMIM : 606921 HomoloGene : 50960 GeneCards : GPR78 Gene location (Human ) Chr. Chromosome 4 (human) [1] Band 4p16.1 Start 8,558,725 bp [1] End 8,619,761 bp [1]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 4: 8.56 – 8.62 Mb n/a PubMed search[2] n/a Wikidata
Not to be confused with GRP78 .
Probable G-protein coupled receptor 78 is a protein that in humans is encoded by the GPR78 gene .[3] [4]
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins .[supplied by OMIM][4]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000155269 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene . 275 (1): 83–91. doi :10.1016/S0378-1119(01)00651-5 . PMID 11574155 .
^ a b "Entrez Gene: GPR78 G protein-coupled receptor 78" .
Further reading [ ]
van Laar T, Schouten T, Hoogervorst E, et al. (2000). "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway" . FEBS Lett . 469 (1): 123–31. doi :10.1016/S0014-5793(00)01253-9 . PMID 10708769 . S2CID 6419566 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 . PMID 12975309 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Underwood SL, Christoforou A, Thomson PA, et al. (2006). "Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia" . Mol. Psychiatry . 11 (4): 384–94. doi :10.1038/sj.mp.4001786 . PMID 16389273 .
Cell surface receptor : G protein-coupled receptors
Neurotransmitter
Adrenergic
α1 (A
B
D )
α2 (A
B
C )
β1
β2
β3
Purinergic
Adenosine (A1
A2A
A2B
A3 )
P2Y (1
2
4
5
6
8
9
10
11
12
13
14 )
Serotonin Other
Acetylcholine (M1
M2
M3
M4
M5 )
Dopamine
GHB receptor
Histamine
Melatonin (1A
1B
1C )
TAAR (1
2
5
6
8
9 )
Metabolites and signaling molecules
Eicosanoid
CysLT (1
2 )
LTB4
FPRL1
OXE
Prostaglandin
DP (1
2 ), EP (1
2
3
4 ), FP
Prostacyclin
Thromboxane
Other
Peptide
Miscellaneous
Taste , sweetOther
Calcium-sensing receptor
GABAB (1
2 )
Glutamate receptor (Metabotropic glutamate (1
2
3
4
5
6
7
8 ))
GPRC6A
GPR (156
158
179 )
RAIG (1
2
3
4 )