There are three known mammalian tachykinin receptors termed NK1 , NK2 and NK3 . All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C , producing inositol triphosphate (so called Gq -coupled).
Inhibitors of NK-1, known as NK-1 receptor antagonists , can be used as antiemetic agents , such as the drug aprepitant .[1]
Binding [ ]
The genes and receptor ligands are as follows:[2]
Receptor
Gene
Preferred ligand
NK1
TACR1
substance P
NK2
TACR2
neurokinin A
NK3
TACR3
neurokinin B
(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
See also [ ]
Substance P
G protein coupled receptors
References [ ]
External links [ ]
"Tachykinin Receptors" . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology.
Tachykinin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
Cell surface receptor : G protein-coupled receptors
Neurotransmitter
Adrenergic
α1 (A
B
D )
α2 (A
B
C )
β1
β2
β3
Purinergic
Adenosine (A1
A2A
A2B
A3 )
P2Y (1
2
4
5
6
8
9
10
11
12
13
14 )
Serotonin Other
Acetylcholine (M1
M2
M3
M4
M5 )
Dopamine
GHB receptor
Histamine
Melatonin (1A
1B
1C )
TAAR (1
2
5
6
8
9 )
Metabolites and signaling molecules
Eicosanoid
CysLT (1
2 )
LTB4
FPRL1
OXE
Prostaglandin
DP (1
2 ), EP (1
2
3
4 ), FP
Prostacyclin
Thromboxane
Other
Bile acid
Cannabinoid (CB1
CB2 , GPR (18
55
119 ))
EBI2
Estrogen
Free fatty acid (1
2
3
4 )
Hydroxycarboxylic acids
Lysophosphatidic acid (1
2
3
4
5
6 )
Lysophospholipid (1
2
3
4
5
6
7
8 )
Oxoglutarate
PAF
Sphingosine-1-phosphate (1
2
3
4
5 )
Succinate
Peptide
Miscellaneous
Taste , sweetOther
Calcium-sensing receptor
GABAB (1
2 )
Glutamate receptor (Metabotropic glutamate (1
2
3
4
5
6
7
8 ))
GPRC6A
GPR (156
158
179 )
RAIG (1
2
3
4 )
G protein-coupled receptor
Hormone receptors
Hypothalamic Pituitary Other
Opioid receptors Other neuropeptide receptors
Type I cytokine receptor Enzyme-linked receptor Other