Free fatty acid receptor

free fatty acid receptor 2
free fatty acid receptor 2
Identifiers
Symbol	FFAR2
Alt. symbols	GPR43, FFA2R
NCBI gene	2867
HGNC	4501
OMIM	603823
RefSeq	NM_005306
UniProt	O15552
Other data
Locus	Chr. 19 q13.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

free fatty acid receptor 1
free fatty acid receptor 1
Identifiers
Symbol	FFAR1, FFA1R
Alt. symbols	GPR40
NCBI gene	2864
HGNC	4498
OMIM	603820
RefSeq	NM_005303
UniProt	O14842
Other data
Locus	Chr. 19 q13.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

free fatty acid receptor 3

Identifiers

Symbol

FFAR3

Alt. symbols

GPR41, FFA3R

NCBI gene

HGNC

OMIM

RefSeq

UniProt

Other data

Chr. 19 q13.1

Search for
Structures	Swiss-model
Domains	InterPro

G protein-coupled receptor 42

Identifiers

Symbol

GPR42

Alt. symbols

GPR41L, FFAR1L

NCBI gene

HGNC

OMIM

RefSeq

UniProt

Other data

Chr. 19 q31.1

Search for
Structures	Swiss-model
Domains	InterPro

The free fatty acid receptor is a G-protein coupled receptor which binds free fatty acids.^[1] There are four variants of the receptor, each encoded by a separate gene (FFAR1, FFAR2, FFAR3, FFAR4). Preliminary findings suggest that FFAR2 and FFAR3 may interact to form a FFAR2-FFAR3 receptor heteromer. ^[2]

References[]

^ Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK (2006). "The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing". Biochem. Soc. Trans. 34 (Pt 5): 770–3. doi:10.1042/BST0340770. PMID 17052194.
^ Ang, Zhiwei; Xiong, Ding; Wu, Min; Ding, Jeak Ling (2017-09-07). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". The FASEB Journal. 32 (1): –201700252RR. doi:10.1096/fj.201700252RR. ISSN 0892-6638. PMC 5731126. PMID 28883043. Retrieved 2017-09-10.

External links[]

"Free Fatty Acid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
FFAR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
G-protein+coupled+receptor+43,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
FFAR3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[pmid17052194-1] Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK (2006). "The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing". Biochem. Soc. Trans. 34 (Pt 5): 770–3. doi:10.1042/BST0340770. PMID 17052194.

[2] Ang, Zhiwei; Xiong, Ding; Wu, Min; Ding, Jeak Ling (2017-09-07). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". The FASEB Journal. 32 (1): –201700252RR. doi:10.1096/fj.201700252RR. ISSN 0892-6638. PMC 5731126. PMID 28883043. Retrieved 2017-09-10.

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