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ADGRD1 Identifiers Aliases ADGRD1 , PGR25, GPR133, adhesion G protein-coupled receptor D1External IDs OMIM : 613639 MGI : 3041203 HomoloGene : 34616 GeneCards : ADGRD1 Gene location (Human ) Chr. Chromosome 12 (human) [1] Band 12q24.33 Start 130,953,907 bp [1] End 131,141,469 bp [1]
Gene location (Mouse ) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 129,173,814 bp [2] End 129,281,663 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 12: 130.95 – 131.14 Mb Chr 5: 129.17 – 129.28 Mb PubMed search[3] [4] Wikidata
Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene .[5] [6]
This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN ) domain.[7] [8]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000111452 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044017 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: GPR133 G protein-coupled receptor 133" .
^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions" . FEBS Lett . 531 (3): 407–14. doi :10.1016/S0014-5793(02)03574-3 . PMID 12435584 . S2CID 7449692 .
^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Berlin: Springer. ISBN 978-1-4419-7912-4 .
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis" . EMBO J . 31 (6): 1364–78. doi :10.1038/emboj.2012.26 . PMC 3321182 . PMID 22333914 .
Further reading [ ]
Vanti WB, Nguyen T, Cheng R, et al. (2003). "Novel human G-protein-coupled receptors". Biochem. Biophys. Res. Commun . 305 (1): 67–71. doi :10.1016/S0006-291X(03)00709-5 . PMID 12732197 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics . 84 (1): 23–33. doi :10.1016/j.ygeno.2003.12.004 . PMID 15203201 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Cell surface receptor : G protein-coupled receptors
Neurotransmitter
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Calcium-sensing receptor
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Categories :
Genes on human chromosome 12 G protein-coupled receptors Transmembrane receptor stubs