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MRGPRX2 Identifiers Aliases MRGPRX2 , MGRG3, MRGX2, MAS related GPR family member X2External IDs OMIM : 607228 MGI : 3588270 HomoloGene : 24986 GeneCards : MRGPRX2 Gene location (Human ) Chr. Chromosome 11 (human) [1] Band 11p15.1 Start 19,054,455 bp [1] End 19,060,717 bp [1]
Gene location (Mouse ) Chr. Chromosome 7 (mouse)[2] Band 7|7 B4 Start 48,128,367 bp [2] End 48,149,069 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 11: 19.05 – 19.06 Mb Chr 7: 48.13 – 48.15 Mb PubMed search[3] [4] Wikidata
Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene .[5] [6]
It is most abundant on cutaneous mast cells.
Agonists are gyrase inhibitors like ciprofloxacin and non-depolarizing neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.
See also [ ]
References [ ]
Further reading [ ]
Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence" . FEBS Lett . 520 (1–3): 97–101. doi :10.1016/S0014-5793(02)02775-8 . PMID 12044878 . S2CID 7116392 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Robas N, Mead E, Fidock M (2004). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion" . J. Biol. Chem . 278 (45): 44400–44404. doi :10.1074/jbc.M302456200 . PMID 12915402 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Yang S, Liu Y, Lin AA, et al. (2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene . 352 : 30–35. doi :10.1016/j.gene.2005.03.001 . PMID 15862286 .
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Genes on human chromosome 11 G protein-coupled receptors Transmembrane receptor stubs