Octacalcium phosphate

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Octacalcium phosphate
Names
IUPAC name
octacalcium dihydrogen hexakis(phosphate) pentahydrate
Other names
Octacalcium Phosphate
Identifiers
  • 13767-12-9 checkY
Properties
Ca8H2(PO4)6⋅5H2O
Molar mass 446.234023 g/mol
Appearance white powder
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY  (what is checkY☒N ?)
Infobox references

Octacalcium phosphate (sometimes referred to as OCP) is a calcium phosphate with a formula Ca8H2(PO4)6⋅5H2O.[1] OCP may be a precursor to tooth enamel, dentine, and bones.

OCP is a precursor of hydroxylapatite (HAP), an inorganic biomineral that is important in bone growth.[2] OCP has been suggested as a replacement for HAP in bone grafts.[3][4][5]

Properties[]

Boiling water decomposes OCP into hydroxyapatite and dicalcium phosphate.[6] Both thermal and hydrothermal treatments sometimes yield apatitic single crystal pseudomorphs after OCP, the c-axes being parallel to the c of the original OCP.[2]

OCP has the lattice constants a = 19.7 Å, b = 9.59 Å, c =6.87 Å, α = β = 90.7° and γ' = 71.8°, slightly different from those of hydroxyapatite.[2] OCP has a strong crystal twinning tendency. The average crystal size of OCP is 13.5 ± 0.2 nm.[6]

Synthesis[]

It can be prepared by treating calcium acetate with sodium acid phosphate solution.[6][1]

References[]

  1. ^ a b LeGeros, Reacquel Z. (1 March 1985). "Preparation of octacalcium phosphate (OCP): A direct fast method". Calcified Tissue International. 37 (2): 194–197. doi:10.1007/BF02554841. PMID 3924374. S2CID 38990778.
  2. ^ a b c Brown, Walter E.; Lehr, James R.; Smith, James P.; Frazier, A. William (October 1957). "Crystallography of Octacalcium Phosphate". Journal of the American Chemical Society. 79 (19): 5318–5319. doi:10.1021/ja01576a068.
  3. ^ Brown, W.E.; Eidelman, N.; Tomazic, B. (December 1987). "Octacalcium Phosphate as a Precursor in Biomineral Formation". Advances in Dental Research. 1 (2): 306–313. doi:10.1177/08959374870010022201. PMID 3504181. S2CID 18686964.
  4. ^ Nelson, D. G. A.; McLean, J. D. (1 December 1984). "High-resolution electron microscopy of octacalcium phosphate and its hydrolysis products". Calcified Tissue International. 36 (1): 219–232. doi:10.1007/BF02405321. PMID 6430505. S2CID 2193217.
  5. ^ Suzuki, O. (September 2010). "Octacalcium phosphate: Osteoconductivity and crystal chemistry". Acta Biomaterialia. 6 (9): 3379–3387. doi:10.1016/j.actbio.2010.04.002. PMID 20371385.
  6. ^ a b c Arellano-Jiménez, M.J.; García-García, R.; Reyes-Gasga, J. (February 2009). "Synthesis and hydrolysis of octacalcium phosphate and its characterization by electron microscopy and X-ray diffraction". Journal of Physics and Chemistry of Solids. 70 (2): 390–395. Bibcode:2009JPCS...70..390A. doi:10.1016/j.jpcs.2008.11.001.

Sources[]

  • Chow, Laurence C.; Eanes, Edward D. (2001). Octacalcium Phosphate. Karger Medical and Scientific Publishers. ISBN 978-3-8055-7228-6.
  • Brown, Walter E.; Lehr, James R.; Smith, James P.; Frazier, A. William (October 1957). "Crystallography of Octacalcium Phosphate". Journal of the American Chemical Society. 79 (19): 5318–5319. doi:10.1021/ja01576a068.
  • Arellano-Jiménez, M.J.; García-García, R.; Reyes-Gasga, J. (February 2009). "Synthesis and hydrolysis of octacalcium phosphate and its characterization by electron microscopy and X-ray diffraction". Journal of Physics and Chemistry of Solids. 70 (2): 390–395. Bibcode:2009JPCS...70..390A. doi:10.1016/j.jpcs.2008.11.001.
  • "Octacalcium phosphate".
  • Suzuki, O. (September 2010). "Octacalcium phosphate: Osteoconductivity and crystal chemistry". Acta Biomaterialia. 6 (9): 3379–3387. doi:10.1016/j.actbio.2010.04.002. PMID 20371385.
  • Nelson, D. G. A.; McLean, J. D. (1 December 1984). "High-resolution electron microscopy of octacalcium phosphate and its hydrolysis products". Calcified Tissue International. 36 (1): 219–232. doi:10.1007/BF02405321. PMID 6430505. S2CID 2193217.
  • Brown, W.E.; Eidelman, N.; Tomazic, B. (December 1987). "Octacalcium Phosphate as a Precursor in Biomineral Formation". Advances in Dental Research. 1 (2): 306–313. doi:10.1177/08959374870010022201. PMID 3504181. S2CID 18686964.
  • Komlev, Vladimir S.; Barinov, Sergei M.; Bozo, Ilya I.; Deev, Roman V.; Eremin, Ilya I.; Fedotov, Alexander Yu.; Gurin, Alex N.; Khromova, Natalia V.; Kopnin, Pavel B.; Kuvshinova, Ekaterina A.; Mamonov, Vasily E.; Rybko, Vera A.; Sergeeva, Natalia S.; Teterina, Anastasia Yu.; Zorin, Vadim L. (8 October 2014). "Bioceramics Composed of Octacalcium Phosphate Demonstrate Enhanced Biological Behavior". ACS Applied Materials & Interfaces. 6 (19): 16610–16620. doi:10.1021/am502583p. PMID 25184694.
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