Outline of life extension

The following outline is provided as an overview of and topical guide to life extension:

Life extension – study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. Also known as anti-aging medicine, experimental gerontology, and biomedical gerontology.

Goals[]

• Biological immortality
• Indefinite lifespan
• Longevity
• Rejuvenation

Longevity[]

• Centenarian
• Supercentenarian
• Longevity escape velocity

Strategies[]

Research and development[]

• Timeline of senescence research

Available strategies[]

• Calorie restriction or or intermittent fasting
• Exercise
• Geroprotector
• Senolytics

Potential future strategies[]

• Cryonics
• Genetic therapies
  • Cloning and body part replacement
  • Cell replacement therapies (CRT)
• Strategies for engineered negligible senescence (SENS)
• Mind uploading
• Suspended animation
• Immunisation

Aging[]

• Evolution of ageing
• Gerontology

Hallmarks of aging[]

• Cellular senescence
• Genomic instability
• Mitochondrial dysfunction

Causes of aging[]

• Cross-links
  • Crosslinking of DNA
• Free radicals – atom, molecule, or ion that has unpaired valence electrons. With some exceptions, these unpaired electrons make free radicals highly chemically reactive towards other substances, or even towards themselves: their molecules will often spontaneously dimerize or polymerize if they come in contact with each other. They are countered to some extent by antioxidants.
• Glycation
  • Advanced glycation end-product
• Lipofuscin
• Viral infections (acute or chronic)

Theories of aging[]

Theories of aging

• Antagonistic pleiotropy theory of aging
• Disposable soma theory of aging
• DNA damage theory of aging
• Free-radical theory of aging
• Glycation theory of aging
• Inflammation theory of aging
• Neuroendocrine theory of aging
• Order to disorder theory of aging
• Rate of living theory
• Reliability theory of aging and longevity
• Reproductive-cell cycle theory
• Somatic mutation theory of aging

Organizations[]

• Alcor Life Extension Foundation
• Alliance for Aging Research
• American Academy of Anti-Aging Medicine
• American Aging Association
• BioViva
• Calico
• Cryonics Institute
• Life Extension Foundation
• Methuselah Foundation – non-profit organization dedicated to extending the healthy human lifespan by advancing tissue engineering and regenerative medicine therapies. It was co-founded in 2003 by Aubrey de Grey and David Gobel, and is based in Springfield, Virginia, United States.
• SENS Research Foundation – 501(c)(3) non-profit organization co-founded by Michael Kope, Aubrey de Grey, Jeff Hall, Sarah Marr and Kevin Perrott, which is based in Mountain View, California, United States. Its activities include research programs and public relations work for the application of regenerative medicine to aging.

Notable people[]

• Aubrey de Grey
• Leonard Hayflick
• Zoltan Istvan
• Saul Kent
• Cynthia Kenyon
• Durk Pearson
• Sandy Shaw
• David Andrew Sinclair
• Roy Walford
• Michael D. West

See also[]

• Attempts to engineer biological immortality in humans
• Outline of transhumanism
• Degeneration (medical)
  • Degenerative disease
  • Neurodegeneration

References[]

Further reading[]

• Ending Aging, a 2007 book which describes Aubrey de Grey's medical proposal for defeating aging (i.e. SENS).

External links[]

• https://www.sens.org/