Phagoburn

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Phagoburn was a European Union-financed phase I/II clinical study focused on testing the medical uses of bacteriophage for treating wounds that ran from 2013 to 2017. The main objective of Phagoburn was to assess the safety, effectiveness and pharmacodynamics of two therapeutic phage cocktails to treat Escherichia coli and Pseudomonas aeruginosa burn wound infections.[1][2] was the main sponsor.[3][4]

The trial was performed in nine hospitals in France and Belgium. A total of 27 patients was included, with 13 randomised to receive phage therapy and the remainder standard treatment. The trial was terminated early because the phage therapy proved less effective than standard treatment at reducing the number of bacteria. The authors concluded that the low concentration of phage tested was insufficient. The primary cause of a lower than expected phage concentration was due to storage instability of the bacteriophages used in the cocktail.[4]

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References[]

  1. ^ Brussow, H. (23 November 2013). "Editorial Commentary: Phage Therapy: Quo Vadis?". Clinical Infectious Diseases. 58 (4): 535–536. doi:10.1093/cid/cit776.
  2. ^ Gross, Michael (June 2014). "Phage therapies for plants and people". Current Biology. 24 (12): R541–R544. doi:10.1016/j.cub.2014.05.064.
  3. ^ Harper, David; Parracho, Helena; Walker, James; Sharp, Richard; Hughes, Gavin; Werthén, Maria; Lehman, Susan; Morales, Sandra (25 June 2014). "Bacteriophages and Biofilms". Antibiotics. 3 (3): 270–284. doi:10.3390/antibiotics3030270. PMC 4790368.
  4. ^ a b Patrick Jault; Thomas Leclerc; Serge Jennes; Jean Paul Pirnay; Yok-Ai Que; et al. (2018). "Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial". Lancet Infectious Diseases. 19: 35–45. doi:10.1016/S1473-3099(18)30482-1. PMID 30292481.

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