Phenuiviridae
Phenuiviridae | |
---|---|
Rift Valley fever virus replication cycle | |
Virus classification | |
(unranked): | Virus |
Realm: | Riboviria |
Kingdom: | Orthornavirae |
Phylum: | Negarnaviricota |
Class: | Ellioviricetes |
Order: | Bunyavirales |
Family: | Phenuiviridae |
Phenuiviridae is a family of negative-strand RNA viruses in the order Bunyavirales.[1] Ruminants, camels, humans, and mosquitoes serve as natural hosts. Member genus Phlebovirus is the only genus of the family that has viruses that cause disease in humans (e.g. Rift Valley fever virus).[2]
Virology[]
Structure[]
Members of Phenuiviridae are enveloped viruses with helical capsid morphology. Envelope glycoproteins of these viruses are distributed with icosahedral symmetry (T=12).[2]
Genome[]
Phenuiviridae is a negative-sense single-stranded RNA virus family.[3] Its genome is segmented into three pieces: L segment (encoding RNA-dependent RNA polymerase), M segment, and S segment.[1]
Some members of the family have ambisense gene encoding on the S segment (nucleocapsid proteins). The M segment includes envelope glycoproteins encoded in a polyprotein that is cleaved by host proteases.[4] Multiple different proteins can be encoded on the M segment due to leaky scanning by the ribosome.[2]
Life cycle[]
RNA transcripts are capped through cap snatching, but not polyadenylated.[4] Translation is terminated by a hairpin sequence at the end of each RNA transcript.[2]
Taxonomy[]
The following genera are recognized:[5]
References[]
- ^ a b "International Committee on Taxonomy of Viruses (ICTV)". International Committee on Taxonomy of Viruses (ICTV). Retrieved 2018-02-02.
- ^ a b c d [1], http://viralzone.expasy.org/7101?outline=all_by_species.
- ^ [2], https://www.uniprot.org/taxonomy/1980418.
- ^ a b Tercero, Breanna; Terasaki, Kaori; Nakagawa, Keisuke; Narayanan, Krishna; Makino, Shinji (Oct 2019). "A strand-specific real-time quantitative RT-PCR assay for distinguishing the genomic and antigenomic RNAs of Rift Valley fever phlebovirus". Journal of Virological Methods. 272: 113701. doi:10.1016/j.jviromet.2019.113701. ISSN 1879-0984. PMC 6698219. PMID 31315022.
- ^ "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 19 May 2021.
- Phenuiviridae
- Bunyavirales
- Virus families
- Virus stubs