Pol (HIV)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/5/57/Hxb2genome.gif/646px-Hxb2genome.gif)
The Gag-Pol region containing the protease gene flanked by p6pol at the N-terminus and reverse transcriptase at the C-terminus.
Pol (DNA polymerase) refers to a gene in retroviruses, or the protein produced by that gene.
Products of pol include:
Reverse transcriptase[]
Common to all retroviruses, this enzyme transcribes the viral RNA into double-stranded DNA.
Integrase[]
This enzyme integrates the DNA produced by reverse transcriptase into the host's genome.
Protease[]
A protease is any enzyme that cuts proteins into segments. HIV's gag and pol genes do not produce their proteins in their final form, but as larger combination proteins; the specific protease used by HIV cleaves these into separate functional units. Protease inhibitor drugs block this step.
See also[]
External links[]
- Gene+Products,+pol at the US National Library of Medicine Medical Subject Headings (MeSH)
- pol+Gene+Products,+Human+Immunodeficiency+Virus at the US National Library of Medicine Medical Subject Headings (MeSH)
Categories:
- Virus stubs
- Viral structural proteins