RAD23A

RAD23A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DV0, 1F4I, 1IFY, 1OQY, 1P98, 1P9D, 1QZE, 1TP4, 2WYQ
Identifiers
Aliases	RAD23A, HHR23A, HR23A, RAD23 homolog A, nucleotide excision repair protein
External IDs	OMIM: 600061 MGI: 105126 HomoloGene: 48322 GeneCards: RAD23A
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,953,642 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,567,294 bp
RNA expression pattern
	Top expressed in
	muscle of leg; ; gastrocnemius muscle; ; vastus lateralis muscle; ; quadriceps femoris muscle; ; biceps brachii; ; deltoid muscle; ; triceps brachii muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	single-stranded DNA binding; ubiquitin-specific protease binding; damaged DNA binding; polyubiquitin modification-dependent protein binding; GO:0001948 protein binding; kinase binding; ubiquitin binding; proteasome binding;
Cellular component	proteasome complex; nucleoplasm; microtubule organizing center; cytosol; nucleus; cytoplasm; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	nucleotide-excision repair; positive regulation of viral genome replication; GO:0022415 viral process; DNA repair; cellular response to DNA damage stimulus; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein destabilization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5886
	19358
	ENSG00000179262
	ENSMUSG00000003813
	P54725
	P54726
	NM_001270362; NM_001270363; NM_005053
NM_001297606; NM_001297607; NM_009010; NM_001378894; NM_001378895;
	NM_001378896
	NP_001257291; NP_001257292; NP_005044
NP_001284535; NP_001284536; NP_033036; NP_001365823; NP_001365824;
	NP_001365825
	Wikidata
View/Edit Human	View/Edit Mouse

UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.^[5]

Function[]

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.^[6]

Interactions[]

RAD23A has been shown to interact with:

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179262 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003813 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ van der Spek PJ, Smit EM, Beverloo HB, Sugasawa K, Masutani C, Hanaoka F, Hoeijmakers JH, Hagemeijer A (March 1995). "Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23". Genomics. 23 (3): 651–658. doi:10.1006/geno.1994.1554. hdl:1765/3069. PMID 7851894.
^ "Entrez Gene: RAD23A RAD23 homolog A (S. cerevisiae)".
^ Wang G, Sawai N, Kotliarova S, Kanazawa I, Nukina N (July 2000). "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B". Hum. Mol. Genet. 9 (12): 1795–803. doi:10.1093/hmg/9.12.1795. PMID 10915768.
^ Hiyama H, Yokoi M, Masutani C, Sugasawa K, Maekawa T, Tanaka K, Hoeijmakers JH, Hanaoka F (September 1999). "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome". J. Biol. Chem. 274 (39): 28019–25. doi:10.1074/jbc.274.39.28019. PMID 10488153.
^ Mueller TD, Feigon J (September 2003). "Structural determinants for the binding of ubiquitin-like domains to the proteasome". EMBO J. 22 (18): 4634–45. doi:10.1093/emboj/cdg467. PMC 212733. PMID 12970176.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading[]

Eichbaum QG, Beatty DW, Parker MI (1994). "Identification of cardiac autoantigens in human heart cDNA libraries using acute rheumatic fever sera". J. Autoimmun. 7 (2): 243–261. doi:10.1006/jaut.1994.1019. PMID 8037842.
Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T, Takio K, Tanaka K, van der Spek PJ, Bootsma D (1994). "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23". EMBO J. 13 (8): 1831–43. doi:10.1002/j.1460-2075.1994.tb06452.x. PMC 395023. PMID 8168482.
van der Spek PJ, Eker A, Rademakers S, Visser C, Sugasawa K, Masutani C, Hanaoka F, Bootsma D, Hoeijmakers JH (1996). "XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes". Nucleic Acids Res. 24 (13): 2551–2559. doi:10.1093/nar/24.13.2551. PMC 145966. PMID 8692695.
van der Spek PJ, Visser CE, Hanaoka F, Smit B, Hagemeijer A, Bootsma D, Hoeijmakers JH (1996). "Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23". Genomics. 31 (1): 20–27. doi:10.1006/geno.1996.0004. hdl:1765/3097. PMID 8808275.
Li L, Lu X, Peterson C, Legerski R (1997). "XPC interacts with both HHR23B and HHR23A in vivo". Mutat. Res. 383 (3): 197–203. doi:10.1016/s0921-8777(97)00002-5. PMID 9164480.
Withers-Ward ES, Jowett JB, Stewart SA, Xie YM, Garfinkel A, Shibagaki Y, Chow SA, Shah N, Hanaoka F, Sawitz DG, Armstrong RW, Souza LM, Chen IS (1997). "Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair". J. Virol. 71 (12): 9732–42. doi:10.1128/JVI.71.12.9732-9742.1997. PMC 230283. PMID 9371639.
Schauber C, Chen L, Tongaonkar P, Vega I, Lambertson D, Potts W, Madura K (1998). "Rad23 links DNA repair to the ubiquitin/proteasome pathway". Nature. 391 (6668): 715–718. doi:10.1038/35661. PMID 9490418. S2CID 4417020.
Gragerov A, Kino T, Ilyina-Gragerova G, Chrousos GP, Pavlakis GN (1998). "HHR23A, the human homologue of the yeast repair protein RAD23, interacts specifically with Vpr protein and prevents cell cycle arrest but not the transcriptional effects of Vpr". Virology. 245 (2): 323–330. doi:10.1006/viro.1998.9138. PMID 9636371.
Dieckmann T, Withers-Ward ES, Jarosinski MA, Liu CF, Chen IS, Feigon J (1998). "Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr". Nat. Struct. Biol. 5 (12): 1042–1047. doi:10.1038/4220. PMID 9846873. S2CID 30478711.
Kumar S, Talis AL, Howley PM (1999). "Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination". J. Biol. Chem. 274 (26): 18785–18792. doi:10.1074/jbc.274.26.18785. PMID 10373495.
Hiyama H, Yokoi M, Masutani C, Sugasawa K, Maekawa T, Tanaka K, Hoeijmakers JH, Hanaoka F (1999). "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome". J. Biol. Chem. 274 (39): 28019–28025. doi:10.1074/jbc.274.39.28019. PMID 10488153.
Miao F, Bouziane M, Dammann R, Masutani C, Hanaoka F, Pfeifer G, O'Connor TR (2000). "3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins". J. Biol. Chem. 275 (37): 28433–28438. doi:10.1074/jbc.M001064200. PMID 10854423.
Wang G, Sawai N, Kotliarova S, Kanazawa I, Nukina N (2000). "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B". Hum. Mol. Genet. 9 (12): 1795–1803. doi:10.1093/hmg/9.12.1795. PMID 10915768.
Withers-Ward ES, Mueller TD, Chen IS, Feigon J (2001). "Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr". Biochemistry. 39 (46): 14103–14112. doi:10.1021/bi0017071. PMID 11087358.
Zhu Q, Wani G, Wani MA, Wani AA (2001). "Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53". Cancer Res. 61 (1): 64–70. PMID 11196199.
Mansky LM, Preveral S, Le Rouzic E, Bernard LC, Selig L, Depienne C, Benarous R, Benichou S (2001). "Interaction of human immunodeficiency virus type 1 Vpr with the HHR23A DNA repair protein does not correlate with multiple biological functions of Vpr". Virology. 282 (1): 176–185. doi:10.1006/viro.2000.0791. PMID 11259200.
Gaynor EM, Chen IS (2001). "Analysis of apoptosis induced by HIV-1 Vpr and examination of the possible role of the hHR23A protein". Exp. Cell Res. 267 (2): 243–257. doi:10.1006/excr.2001.5247. PMID 11426943.
Chen L, Shinde U, Ortolan TG, Madura K (2002). "Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly". EMBO Rep. 2 (10): 933–938. doi:10.1093/embo-reports/kve203. PMC 1084081. PMID 11571271.
Elder RT, Song XQ, Chen M, Hopkins KM, Lieberman HB, Zhao Y (2002). "Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination". Nucleic Acids Res. 30 (2): 581–591. doi:10.1093/nar/30.2.581. PMC 99819. PMID 11788722.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179262 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003813 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7851894-5] van der Spek PJ, Smit EM, Beverloo HB, Sugasawa K, Masutani C, Hanaoka F, Hoeijmakers JH, Hagemeijer A (March 1995). "Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23". Genomics. 23 (3): 651–658. doi:10.1006/geno.1994.1554. hdl:1765/3069. PMID 7851894.

[entrez-6] "Entrez Gene: RAD23A RAD23 homolog A (S. cerevisiae)".

[pmid10915768-7] Wang G, Sawai N, Kotliarova S, Kanazawa I, Nukina N (July 2000). "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B". Hum. Mol. Genet. 9 (12): 1795–803. doi:10.1093/hmg/9.12.1795. PMID 10915768.

[pmid10488153-8] Hiyama H, Yokoi M, Masutani C, Sugasawa K, Maekawa T, Tanaka K, Hoeijmakers JH, Hanaoka F (September 1999). "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome". J. Biol. Chem. 274 (39): 28019–25. doi:10.1074/jbc.274.39.28019. PMID 10488153.

[pmid12970176-9] Mueller TD, Feigon J (September 2003). "Structural determinants for the binding of ubiquitin-like domains to the proteasome". EMBO J. 22 (18): 4634–45. doi:10.1093/emboj/cdg467. PMC 212733. PMID 12970176.

[pmid16189514-10] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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v t DNA repair
Excision repair	Base excision repair/AP site DNA glycosylase Uracil-DNA glycosylase Poly ADP ribose polymerase Nucleotide excision repair/ERCC XPA XPB XPC XPD/ERCC2 XPE/DDB1 XPF/DDB1 XPG/ERCC5 ERCC1 RPA RAD23A RAD23B Excinuclease DNA mismatch repair MLH1 MSH2
Other forms of repair	Transcription-coupled repair ERCC6 ERCC8 Homology directed repair Non-homologous end joining Ku Microhomology-mediated end joining Postreplication repair Photolyase CRY1 CRY2
Other/ungrouped proteins	Ogt PcrA Proliferating Cell Nuclear Antigen Homologous recombination RecA/RAD51 Sgs1 Slx4
Regulation	SOS box SOS response
Other/ungrouped	8-Oxoguanine Adaptive response Meiotic recombination checkpoint RecF pathway DNA helicase: BLM WRN FANC proteins: core protein complex FANCA FANCB FANCC FANCE FANCF FANCG FANCL FANCM FANCD1 FANCD2 FANCI FANCJ FANCN