RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.[5]
Clinical significance[]
Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiative state of endometrial cells through the regulation of bioavailability of retinol. On the converse, loss of CRBP-1 is associated with development of endometrial cancer.[8]
^De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L (1998). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 226–7. doi:10.1159/000015107. PMID9858824. S2CID46851294.
Colantuoni V, Cortese R, Nilsson M, et al. (1985). "Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein". Biochem. Biophys. Res. Commun. 130 (1): 431–9. doi:10.1016/0006-291X(85)90435-8. PMID2992469.
Kooistra T, Lansink M, Arts J, et al. (1995). "Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells". Eur. J. Biochem. 232 (2): 425–32. doi:10.1111/j.1432-1033.1995.425zz.x. PMID7556191.
Liu W, Hellman P, Li Q, et al. (1997). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells". Biochem. Biophys. Res. Commun. 229 (3): 922–9. doi:10.1006/bbrc.1996.1903. PMID9005841.
De Baere E, Speleman F, Van Roy N, et al. (1999). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 226–7. doi:10.1159/000015107. PMID9858824. S2CID46851294.
Orlandi A, Francesconi A, Clément S, et al. (2002). "High levels of cellular retinol binding protein-1 expression in leiomyosarcoma: possible implications for diagnostic evaluation". Virchows Arch. 441 (1): 31–40. doi:10.1007/s00428-001-0576-7. PMID12111198. S2CID195243470.
Cvetković D, Williams SJ, Hamilton TC (2003). "Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer". Clin. Cancer Res. 9 (3): 1013–20. PMID12631600.
Hosaka B, Park SI, Felipe CR, et al. (2004). "Predictive value of urinary retinol binding protein for graft dysfunction after kidney transplantation". Transplant. Proc. 35 (4): 1341–3. doi:10.1016/S0041-1345(03)00380-4. PMID12826154.
1crb: CRYSTALLOGRAPHIC STUDIES ON A FAMILY OF CELLULAR LIPOPHILIC TRANSPORT PROTEINS. REFINEMENT OF P2 MYELIN PROTEIN AND THE STRUCTURE DETERMINATION AND REFINEMENT OF CELLULAR RETINOL-BINDING PROTEIN IN COMPLEX WITH ALL-TRANS-RETINOL
1jbh: Solution structure of cellular retinol binding protein type-I in the ligand-free state
1kgl: Solution structure of cellular retinol binding protein type-I in complex with all-trans-retinol
1mx7: Two homologous rat cellular retinol-binding proteins differ in local structure and flexibility
1mx8: Two homologous rat cellular retinol-binding proteins differ in local structure and flexibility
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