Realgar/Indigo naturalis

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Realgar/Indigo naturalis
Combination of
RealgarArsenic compound
Indigo naturalisTraditional Chinese medicine
Clinical data
Other namesRIF oral arsenic formulation, Compound Huangdai
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • US: Not FDA approved

Realgar/Indigo naturalis (RIF), also known as Compound Huangdai, is a medication used to treat acute promyelocytic leukemia.[1] Effectiveness appears similar to arsenic trioxide.[1] It is generally used together with all-trans-retinoic acid (ATRA).[1] It is taken by mouth.[2]

Side effects may include abdominal pain and rash.[1] It is made up of a combination of realgar (tetra-arsenic tetra-sulfide), Indigo naturalis, root of Salvia miltiorrhiza, and root of Pseudostellaria heterophylla.[1] It works by breaking down the cancer protein retinoic acid receptor alpha.[3]

Realgar-Indigo naturalis was developed in the 1980s and approved for medical use in China in 2009.[1][4] It is on the World Health Organization's List of Essential Medicines.[2] It is made in China and was originally a herbal remedy.[1] It is not approved in either the United States or Europe as of 2019.[1]

See also[]

  • Indirubin
  • Realgar/Indigo naturalis
  • Indigo naturalis

References[]

  1. ^ Jump up to: a b c d e f g h "Proposal for the inclusion of arsenic therapies in the WHO Model list of ESSENTIAL MEDICINES for the treatment of acute promyelocytic leukemia" (PDF). WHO. Retrieved 15 November 2019.
  2. ^ Jump up to: a b World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  3. ^ "realgar-Indigo naturalis formulation". National Cancer Institute. 2 February 2011. Retrieved 15 November 2019.
  4. ^ Ghosh, Dilip; Smarta, R. B. (2016). Pharmaceuticals to Nutraceuticals: A Shift in Disease Prevention. CRC Press. p. PT41. ISBN 9781315354934.
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